DegronMD - P00747(PLG)

GO - Biological processes (BP): View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

Choose a PDB ID:
Open in full screen with detailed sequence annotations

Data table is loading....

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P465A	TCGA-85-A4QQ	LUSC	TCGA	VETPSEE	DEG_SCF_FBW7_2	473:479	Mutation rewiring degron network	0.1111
p.P465A	DO45427	LUSC	ICGC	VETPSEE	DEG_SCF_FBW7_2	473:479	Mutation rewiring degron network	0.1111
p.L469P	TCGA-A3-3378	KIRC	TCGA	VETPSEE	DEG_SCF_FBW7_2	473:479	Mutation rewiring degron network	0.2222
p.P476H	TCGA-BF-A1Q0	SKCM	TCGA	VETPSEE	DEG_SCF_FBW7_2	473:479	Mutation altering degron motif	0.7694
p.P476H	DO47374	SKCM	ICGC	VETPSEE	DEG_SCF_FBW7_2	473:479	Mutation altering degron motif	0.7694
p.P465S	TCGA-EE-A3AA	SKCM	TCGA	VETPSEE	DEG_SCF_FBW7_2	473:479	Mutation rewiring degron network	0.1111
p.P465S	DO222632	MELA	ICGC	VETPSEE	DEG_SCF_FBW7_2	473:479	Mutation rewiring degron network	0.1111
p.P465S	DO37571	SKCM	ICGC	VETPSEE	DEG_SCF_FBW7_2	473:479	Mutation rewiring degron network	0.1111
p.P466L	TCGA-ER-A193	SKCM	TCGA	VETPSEE	DEG_SCF_FBW7_2	473:479	Mutation rewiring degron network	0.1389
p.P466L	DO47368	SKCM	ICGC	VETPSEE	DEG_SCF_FBW7_2	473:479	Mutation rewiring degron network	0.1389
p.L470F	TCGA-FW-A3R5	SKCM	TCGA	VETPSEE	DEG_SCF_FBW7_2	473:479	Mutation rewiring degron network	0.25
p.L470F	DO37406	SKCM	ICGC	VETPSEE	DEG_SCF_FBW7_2	473:479	Mutation rewiring degron network	0.25
p.E474Q	TCGA-K4-A54R	BLCA	TCGA	VETPSEE	DEG_SCF_FBW7_2	473:479	Mutation altering degron motif	0.5633
p.E474Q	DO48611	BLCA	ICGC	VETPSEE	DEG_SCF_FBW7_2	473:479	Mutation altering degron motif	0.5633
p.E474K	TCGA-W3-AA1V	SKCM	TCGA	VETPSEE	DEG_SCF_FBW7_2	473:479	Mutation altering degron motif	0.591
p.E474K	DO51276	SKCM	ICGC	VETPSEE	DEG_SCF_FBW7_2	473:479	Mutation altering degron motif	0.591
p.A463E	DO48374	BLCA	ICGC	VETPSEE	DEG_SCF_FBW7_2	473:479	Mutation rewiring degron network	0.0556
p.D480E	DO228974	LICA	ICGC	VETPSEE	DEG_SCF_FBW7_2	473:479	Mutation rewiring degron network	0.3056
p.V467F	DO228976	LICA	ICGC	VETPSEE	DEG_SCF_FBW7_2	473:479	Mutation rewiring degron network	0.1667
p.D472N	DO230990	LUSC	ICGC	VETPSEE	DEG_SCF_FBW7_2	473:479	Mutation rewiring degron network	0.3056
p.D472N	DO218908	SKCA	ICGC	VETPSEE	DEG_SCF_FBW7_2	473:479	Mutation rewiring degron network	0.3056
p.G484E	DO220877	MELA	ICGC	VETPSEE	DEG_SCF_FBW7_2	473:479	Mutation rewiring degron network	0.1944
p.P465R	SIDM00739	Non-Small Cell Lung Carcinoma	GDSC	VETPSEE	DEG_SCF_FBW7_2	473:479	Mutation rewiring degron network	0.1111
p.P465R	ACH-000675	Lung Cancer	CCLE	VETPSEE	DEG_SCF_FBW7_2	473:479	Mutation rewiring degron network	0.1111
p.P465R	NCI-H1734	lung	COSMIC	VETPSEE	DEG_SCF_FBW7_2	473:479	Mutation rewiring degron network	0.1111
p.G488E	SIDM00737	Non-Small Cell Lung Carcinoma	GDSC	VETPSEE	DEG_SCF_FBW7_2	473:479	Mutation rewiring degron network	0.0833
p.G488E	ACH-001362	Lung Cancer	CCLE	VETPSEE	DEG_SCF_FBW7_2	473:479	Mutation rewiring degron network	0.0833
p.G488E	NCI-H1770	lung	COSMIC	VETPSEE	DEG_SCF_FBW7_2	473:479	Mutation rewiring degron network	0.0833

Kaplan plot for PLG in

Select cancer type:
Download patient class data (Lower:Upper = 50%:50%)

*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

PLG

UniProt ID: P00747

Entrez ID: 5340

Protein name: Plasminogen (EC 3.4.21.7) [Cleaved into: Plasmin heavy chain A; Activation peptide; Angiostatin; Plasmin heavy chain A, short form; Plasmin light chain B]

External links: UniprotKB HGNC RefSeq COSMIC

Data table is loading....

Kaplan plot for PLG in