DegronMD

Uniprot ID: P00747

Source protein: Plasminogen

Source gene: PLG

Class: DEG_SCF_FBW7_2

Location: 473:479

E3 ligase: FBXW7

DEGRON score: 0.809

ASA_SCORE: 82.2714

COIL: 0.7294

CONS_SCORE: 0.4936

DSS_SCORE: 0.4235

HELIX: 0.1003

FCONS_SCORE: 0.9441

RIG_SCORE: 0.7692

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P465A	TCGA-85-A4QQ	LUSC	TCGA	VETPSEE	DEG_SCF_FBW7_2	0.1111
p.P465A	DO45427	LUSC	ICGC	VETPSEE	DEG_SCF_FBW7_2	0.1111
p.L469P	TCGA-A3-3378	KIRC	TCGA	VETPSEE	DEG_SCF_FBW7_2	0.2222
p.P476H	TCGA-BF-A1Q0	SKCM	TCGA	VETPSEE	DEG_SCF_FBW7_2	0.7694
p.P476H	DO47374	SKCM	ICGC	VETPSEE	DEG_SCF_FBW7_2	0.7694
p.P465S	TCGA-EE-A3AA	SKCM	TCGA	VETPSEE	DEG_SCF_FBW7_2	0.1111
p.P465S	DO222632	MELA	ICGC	VETPSEE	DEG_SCF_FBW7_2	0.1111
p.P465S	DO37571	SKCM	ICGC	VETPSEE	DEG_SCF_FBW7_2	0.1111
p.P466L	TCGA-ER-A193	SKCM	TCGA	VETPSEE	DEG_SCF_FBW7_2	0.1389
p.P466L	DO47368	SKCM	ICGC	VETPSEE	DEG_SCF_FBW7_2	0.1389
p.L470F	TCGA-FW-A3R5	SKCM	TCGA	VETPSEE	DEG_SCF_FBW7_2	0.25
p.L470F	DO37406	SKCM	ICGC	VETPSEE	DEG_SCF_FBW7_2	0.25
p.E474Q	TCGA-K4-A54R	BLCA	TCGA	VETPSEE	DEG_SCF_FBW7_2	0.5633
p.E474Q	DO48611	BLCA	ICGC	VETPSEE	DEG_SCF_FBW7_2	0.5633
p.E474K	TCGA-W3-AA1V	SKCM	TCGA	VETPSEE	DEG_SCF_FBW7_2	0.591
p.E474K	DO51276	SKCM	ICGC	VETPSEE	DEG_SCF_FBW7_2	0.591
p.A463E	DO48374	BLCA	ICGC	VETPSEE	DEG_SCF_FBW7_2	0.0556
p.D480E	DO228974	LICA	ICGC	VETPSEE	DEG_SCF_FBW7_2	0.3056
p.V467F	DO228976	LICA	ICGC	VETPSEE	DEG_SCF_FBW7_2	0.1667
p.D472N	DO230990	LUSC	ICGC	VETPSEE	DEG_SCF_FBW7_2	0.3056
p.D472N	DO218908	SKCA	ICGC	VETPSEE	DEG_SCF_FBW7_2	0.3056
p.G484E	DO220877	MELA	ICGC	VETPSEE	DEG_SCF_FBW7_2	0.1944
p.P465R	SIDM00739	Non-Small Cell Lung Carcinoma	GDSC	VETPSEE	DEG_SCF_FBW7_2	0.1111
p.P465R	ACH-000675	Lung Cancer	CCLE	VETPSEE	DEG_SCF_FBW7_2	0.1111
p.P465R	NCI-H1734	lung	COSMIC	VETPSEE	DEG_SCF_FBW7_2	0.1111
p.G488E	SIDM00737	Non-Small Cell Lung Carcinoma	GDSC	VETPSEE	DEG_SCF_FBW7_2	0.0833
p.G488E	ACH-001362	Lung Cancer	CCLE	VETPSEE	DEG_SCF_FBW7_2	0.0833
p.G488E	NCI-H1770	lung	COSMIC	VETPSEE	DEG_SCF_FBW7_2	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P00747	Plasminogen	DEG_SCF_FBW7_2	473:479	VETPSEE	FBXW7	0.809	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: VETPSEE

Degron related mutations and impact score

Drug responses associated with PLG mutations

All proteins holding degron of VETPSEE