DegronMD - P00751(CFB)

CFB

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.Q682R	TCGA-A5-A0G2	UCEC	TCGA	VSPYAD	LIG_APCC_ABBA_1	686:691	Mutation rewiring degron network	0.2222
p.Q682R	DO41235	UCEC	ICGC	VSPYAD	LIG_APCC_ABBA_1	686:691	Mutation rewiring degron network	0.2222
p.R700C	TCGA-A5-A0G2	UCEC	TCGA	VSPYAD	LIG_APCC_ABBA_1	686:691	Mutation rewiring degron network	0.0833
p.R700C	DO41235	UCEC	ICGC	VSPYAD	LIG_APCC_ABBA_1	686:691	Mutation rewiring degron network	0.0833
p.V689I	TCGA-B5-A3FC	UCEC	TCGA	VSPYAD	LIG_APCC_ABBA_1	686:691	Mutation altering degron motif	0.7076
p.V689I	DO41871	UCEC	ICGC	VSPYAD	LIG_APCC_ABBA_1	686:691	Mutation altering degron motif	0.7076
p.H692P	TCGA-CC-A9FS	LIHC	TCGA	VSPYAD	LIG_APCC_ABBA_1	686:691	Mutation rewiring degron network	0.3056
p.H692P	DO219553	LIHC	ICGC	VSPYAD	LIG_APCC_ABBA_1	686:691	Mutation rewiring degron network	0.3056
p.R684H	TCGA-D6-A6EM	HNSC	TCGA	VSPYAD	LIG_APCC_ABBA_1	686:691	Mutation rewiring degron network	0.2778
p.R684H	DO52081	HNSC	ICGC	VSPYAD	LIG_APCC_ABBA_1	686:691	Mutation rewiring degron network	0.2778
p.V679M	DO223050	ESCA	ICGC	VSPYAD	LIG_APCC_ABBA_1	686:691	Mutation rewiring degron network	0.1389
p.N682D	ACH-000085	Pancreatic Cancer	CCLE	VSPYAD	LIG_APCC_ABBA_1	686:691	Mutation rewiring degron network	0.2222
p.N682D	ACH-000372	Leukemia	CCLE	VSPYAD	LIG_APCC_ABBA_1	686:691	Mutation rewiring degron network	0.2222
p.N682D	ACH-001275	Sarcoma	CCLE	VSPYAD	LIG_APCC_ABBA_1	686:691	Mutation rewiring degron network	0.2222
p.D679E	ACH-000889	Myeloma	CCLE	VSPYAD	LIG_APCC_ABBA_1	686:691	Mutation rewiring degron network	0.1389

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*NOTE: the Kaplan plots were collected from OncoLnc