DegronMD

Uniprot ID: P00751

Source protein: Complement factor B

Source gene: CFB

Class: LIG_APCC_ABBA_1

Location: 686:691

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.726

ASA_SCORE: 84.2167

COIL: 0.904

CONS_SCORE: 0.4658

DSS_SCORE: 0.3212

HELIX: 0.0358

FCONS_SCORE: 0.8141

RIG_SCORE: 0.7453

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.Q682R	TCGA-A5-A0G2	UCEC	TCGA	VSPYAD	LIG_APCC_ABBA_1	0.2222
p.Q682R	DO41235	UCEC	ICGC	VSPYAD	LIG_APCC_ABBA_1	0.2222
p.R700C	TCGA-A5-A0G2	UCEC	TCGA	VSPYAD	LIG_APCC_ABBA_1	0.0833
p.R700C	DO41235	UCEC	ICGC	VSPYAD	LIG_APCC_ABBA_1	0.0833
p.V689I	TCGA-B5-A3FC	UCEC	TCGA	VSPYAD	LIG_APCC_ABBA_1	0.7076
p.V689I	DO41871	UCEC	ICGC	VSPYAD	LIG_APCC_ABBA_1	0.7076
p.H692P	TCGA-CC-A9FS	LIHC	TCGA	VSPYAD	LIG_APCC_ABBA_1	0.3056
p.H692P	DO219553	LIHC	ICGC	VSPYAD	LIG_APCC_ABBA_1	0.3056
p.R684H	TCGA-D6-A6EM	HNSC	TCGA	VSPYAD	LIG_APCC_ABBA_1	0.2778
p.R684H	DO52081	HNSC	ICGC	VSPYAD	LIG_APCC_ABBA_1	0.2778
p.V679M	DO223050	ESCA	ICGC	VSPYAD	LIG_APCC_ABBA_1	0.1389
p.N682D	ACH-000085	Pancreatic Cancer	CCLE	VSPYAD	LIG_APCC_ABBA_1	0.2222
p.N682D	ACH-000372	Leukemia	CCLE	VSPYAD	LIG_APCC_ABBA_1	0.2222
p.N682D	ACH-001275	Sarcoma	CCLE	VSPYAD	LIG_APCC_ABBA_1	0.2222
p.D679E	ACH-000889	Myeloma	CCLE	VSPYAD	LIG_APCC_ABBA_1	0.1389

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P00751	Complement factor B	LIG_APCC_ABBA_1	686:691	VSPYAD	APC,CDC20,FZR1	0.726	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons