DegronMD - P01023(A2M)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.G1310W	TCGA-64-1676	LUAD	TCGA	NRLLLQQVS	DEG_APCC_DBOX_1	1296:1304	Mutation rewiring degron network	0.1667
p.G1310W	DO23629	LUAD	ICGC	NRLLLQQVS	DEG_APCC_DBOX_1	1296:1304	Mutation rewiring degron network	0.1667
p.S1313N	TCGA-AA-3672	COAD	TCGA	NRLLLQQVS	DEG_APCC_DBOX_1	1296:1304	Mutation rewiring degron network	0.0833
p.S1313N	DO9010	COAD	ICGC	NRLLLQQVS	DEG_APCC_DBOX_1	1296:1304	Mutation rewiring degron network	0.0833
p.M1314I	TCGA-AX-A0J0	UCEC	TCGA	NRLLLQQVS	DEG_APCC_DBOX_1	1296:1304	Mutation rewiring degron network	0.0556
p.M1314I	DO41133	UCEC	ICGC	NRLLLQQVS	DEG_APCC_DBOX_1	1296:1304	Mutation rewiring degron network	0.0556
p.P1306Q	TCGA-CJ-4920	KIRC	TCGA	NRLLLQQVS	DEG_APCC_DBOX_1	1296:1304	Mutation rewiring degron network	0.2778
p.P1306Q	DO18681	KIRC	ICGC	NRLLLQQVS	DEG_APCC_DBOX_1	1296:1304	Mutation rewiring degron network	0.2778
p.R1297H	TCGA-E6-A1LX	UCEC	TCGA	NRLLLQQVS	DEG_APCC_DBOX_1	1296:1304	Mutation altering degron motif	0.8244
p.R1297H	DO41020	UCEC	ICGC	NRLLLQQVS	DEG_APCC_DBOX_1	1296:1304	Mutation altering degron motif	0.8244
p.E1311K	TCGA-ER-A19N	SKCM	TCGA	NRLLLQQVS	DEG_APCC_DBOX_1	1296:1304	Mutation rewiring degron network	0.1389
p.E1311K	TCGA-FW-A3R5	SKCM	TCGA	NRLLLQQVS	DEG_APCC_DBOX_1	1296:1304	Mutation rewiring degron network	0.1389
p.E1311K	DO37406	SKCM	ICGC	NRLLLQQVS	DEG_APCC_DBOX_1	1296:1304	Mutation rewiring degron network	0.1389
p.E1311K	DO37452	SKCM	ICGC	NRLLLQQVS	DEG_APCC_DBOX_1	1296:1304	Mutation rewiring degron network	0.1389
p.S1304L	TCGA-ER-A3PL	SKCM	TCGA	NRLLLQQVS	DEG_APCC_DBOX_1	1296:1304	Mutation altering degron motif	0.6556
p.S1304L	DO37495	SKCM	ICGC	NRLLLQQVS	DEG_APCC_DBOX_1	1296:1304	Mutation altering degron motif	0.6556
p.R1297C	DO234396	ESAD	ICGC	NRLLLQQVS	DEG_APCC_DBOX_1	1296:1304	Mutation altering degron motif	0.8301

Kaplan plot for A2M in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

A2M

UniProt ID: P01023

Entrez ID: 2

Protein name: Alpha-2-macroglobulin (Alpha-2-M) (C3 and PZP-like alpha-2-macroglobulin domain-containing protein 5)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for A2M in