DegronMD

Uniprot ID: P01023

Source protein: Alpha-2-macroglobulin

Source gene: A2M

Class: DEG_APCC_DBOX_1

Location: 1296:1304

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.6076

ASA_SCORE: 57

COIL: 0.2481

CONS_SCORE: 0.6252

DSS_SCORE: 0.2755

HELIX: 0.0157

FCONS_SCORE: 1.153

RIG_SCORE: 0.8407

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G1310W	TCGA-64-1676	LUAD	TCGA	NRLLLQQVS	DEG_APCC_DBOX_1	0.1667
p.G1310W	DO23629	LUAD	ICGC	NRLLLQQVS	DEG_APCC_DBOX_1	0.1667
p.S1313N	TCGA-AA-3672	COAD	TCGA	NRLLLQQVS	DEG_APCC_DBOX_1	0.0833
p.S1313N	DO9010	COAD	ICGC	NRLLLQQVS	DEG_APCC_DBOX_1	0.0833
p.M1314I	TCGA-AX-A0J0	UCEC	TCGA	NRLLLQQVS	DEG_APCC_DBOX_1	0.0556
p.M1314I	DO41133	UCEC	ICGC	NRLLLQQVS	DEG_APCC_DBOX_1	0.0556
p.P1306Q	TCGA-CJ-4920	KIRC	TCGA	NRLLLQQVS	DEG_APCC_DBOX_1	0.2778
p.P1306Q	DO18681	KIRC	ICGC	NRLLLQQVS	DEG_APCC_DBOX_1	0.2778
p.R1297H	TCGA-E6-A1LX	UCEC	TCGA	NRLLLQQVS	DEG_APCC_DBOX_1	0.8244
p.R1297H	DO41020	UCEC	ICGC	NRLLLQQVS	DEG_APCC_DBOX_1	0.8244
p.E1311K	TCGA-ER-A19N	SKCM	TCGA	NRLLLQQVS	DEG_APCC_DBOX_1	0.1389
p.E1311K	TCGA-FW-A3R5	SKCM	TCGA	NRLLLQQVS	DEG_APCC_DBOX_1	0.1389
p.E1311K	DO37406	SKCM	ICGC	NRLLLQQVS	DEG_APCC_DBOX_1	0.1389
p.E1311K	DO37452	SKCM	ICGC	NRLLLQQVS	DEG_APCC_DBOX_1	0.1389
p.S1304L	TCGA-ER-A3PL	SKCM	TCGA	NRLLLQQVS	DEG_APCC_DBOX_1	0.6556
p.S1304L	DO37495	SKCM	ICGC	NRLLLQQVS	DEG_APCC_DBOX_1	0.6556
p.R1297C	DO234396	ESAD	ICGC	NRLLLQQVS	DEG_APCC_DBOX_1	0.8301

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P01023	Alpha-2-macroglobulin	DEG_APCC_DBOX_1	1296:1304	NRLLLQQVS	APC,CDC20,FZR1	0.6076	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons