DegronMD - P01589(IL2RA)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.Q97E	TCGA-CN-5370	HNSC	TCGA	VTPQPE	DEG_SCF_FBW7_2	94:99	Mutation altering degron motif	0.5633
p.Q97E	DO15126	HNSC	ICGC	VTPQPE	DEG_SCF_FBW7_2	94:99	Mutation altering degron motif	0.5633
p.Q97E	ACH-000975	Lung Cancer	CCLE	VTPQPE	DEG_SCF_FBW7_2	94:99	Mutation altering degron motif	0.5633
p.A86P	TCGA-CZ-4853	KIRC	TCGA	VTPQPE	DEG_SCF_FBW7_2	94:99	Mutation rewiring degron network	0.1111
p.A86P	DO16111	KIRC	ICGC	VTPQPE	DEG_SCF_FBW7_2	94:99	Mutation rewiring degron network	0.1111
p.S85F	TCGA-DA-A95Z	SKCM	TCGA	VTPQPE	DEG_SCF_FBW7_2	94:99	Mutation rewiring degron network	0.0833
p.S85F	DO219481	SKCM	ICGC	VTPQPE	DEG_SCF_FBW7_2	94:99	Mutation rewiring degron network	0.0833
p.T91A	TCGA-DI-A1BU	UCEC	TCGA	VTPQPE	DEG_SCF_FBW7_2	94:99	Mutation rewiring degron network	0.25
p.T91A	DO42023	UCEC	ICGC	VTPQPE	DEG_SCF_FBW7_2	94:99	Mutation rewiring degron network	0.25
p.E103K	TCGA-EE-A3AE	SKCM	TCGA	VTPQPE	DEG_SCF_FBW7_2	94:99	Mutation rewiring degron network	0.2222
p.E103K	DO37802	SKCM	ICGC	VTPQPE	DEG_SCF_FBW7_2	94:99	Mutation rewiring degron network	0.2222
p.R88G	TCGA-JY-A93E	ESCA	TCGA	VTPQPE	DEG_SCF_FBW7_2	94:99	Mutation rewiring degron network	0.1667
p.N89K	DO229018	LICA	ICGC	VTPQPE	DEG_SCF_FBW7_2	94:99	Mutation rewiring degron network	0.1944
p.T95K	DO229063	LICA	ICGC	VTPQPE	DEG_SCF_FBW7_2	94:99	Mutation altering degron motif	0.7306
p.T95K	DO229008	LICA	ICGC	VTPQPE	DEG_SCF_FBW7_2	94:99	Mutation altering degron motif	0.7306
p.Q101H	DO232224	PBCA	ICGC	VTPQPE	DEG_SCF_FBW7_2	94:99	Mutation rewiring degron network	0.2778
p.E99K	SIDM00586	Hepatocellular Carcinoma	GDSC	VTPQPE	DEG_SCF_FBW7_2	94:99	Mutation altering degron motif	0.7022
p.E99K	ACH-000475	Liver Cancer	CCLE	VTPQPE	DEG_SCF_FBW7_2	94:99	Mutation altering degron motif	0.7022
p.E99K	huH-1	liver	COSMIC	VTPQPE	DEG_SCF_FBW7_2	94:99	Mutation altering degron motif	0.7022

Kaplan plot for IL2RA in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

IL2RA

UniProt ID: P01589

Entrez ID: 3559

Protein name: Interleukin-2 receptor subunit alpha (IL-2 receptor subunit alpha) (IL-2-RA) (IL-2R subunit alpha) (IL2-RA) (TAC antigen) (p55) (CD antigen CD25)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for IL2RA in