DegronMD

Uniprot ID: P01589

Source protein: Interleukin-2 receptor subunit alpha

Source gene: IL2RA

Class: DEG_SCF_FBW7_2

Location: 94:99

E3 ligase: FBXW7

DEGRON score: 0.931

ASA_SCORE: 78.65

COIL: 0.69

CONS_SCORE: 0.6325

DSS_SCORE: 0.7446

HELIX: 0.062

FCONS_SCORE: 1.2667

RIG_SCORE: 0.6557

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.Q97E	TCGA-CN-5370	HNSC	TCGA	VTPQPE	DEG_SCF_FBW7_2	0.5633
p.Q97E	DO15126	HNSC	ICGC	VTPQPE	DEG_SCF_FBW7_2	0.5633
p.Q97E	ACH-000975	Lung Cancer	CCLE	VTPQPE	DEG_SCF_FBW7_2	0.5633
p.A86P	TCGA-CZ-4853	KIRC	TCGA	VTPQPE	DEG_SCF_FBW7_2	0.1111
p.A86P	DO16111	KIRC	ICGC	VTPQPE	DEG_SCF_FBW7_2	0.1111
p.S85F	TCGA-DA-A95Z	SKCM	TCGA	VTPQPE	DEG_SCF_FBW7_2	0.0833
p.S85F	DO219481	SKCM	ICGC	VTPQPE	DEG_SCF_FBW7_2	0.0833
p.T91A	TCGA-DI-A1BU	UCEC	TCGA	VTPQPE	DEG_SCF_FBW7_2	0.25
p.T91A	DO42023	UCEC	ICGC	VTPQPE	DEG_SCF_FBW7_2	0.25
p.E103K	TCGA-EE-A3AE	SKCM	TCGA	VTPQPE	DEG_SCF_FBW7_2	0.2222
p.E103K	DO37802	SKCM	ICGC	VTPQPE	DEG_SCF_FBW7_2	0.2222
p.R88G	TCGA-JY-A93E	ESCA	TCGA	VTPQPE	DEG_SCF_FBW7_2	0.1667
p.N89K	DO229018	LICA	ICGC	VTPQPE	DEG_SCF_FBW7_2	0.1944
p.T95K	DO229063	LICA	ICGC	VTPQPE	DEG_SCF_FBW7_2	0.7306
p.T95K	DO229008	LICA	ICGC	VTPQPE	DEG_SCF_FBW7_2	0.7306
p.Q101H	DO232224	PBCA	ICGC	VTPQPE	DEG_SCF_FBW7_2	0.2778
p.E99K	SIDM00586	Hepatocellular Carcinoma	GDSC	VTPQPE	DEG_SCF_FBW7_2	0.7022
p.E99K	ACH-000475	Liver Cancer	CCLE	VTPQPE	DEG_SCF_FBW7_2	0.7022
p.E99K	huH-1	liver	COSMIC	VTPQPE	DEG_SCF_FBW7_2	0.7022

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O95273	Cyclin-D1-binding protein 1	DEG_SCF_FBW7_2	327:332	VTPQPE	FBXW7	0.6252	More...
P01589	Interleukin-2 receptor subunit alpha	DEG_SCF_FBW7_2	94:99	VTPQPE	FBXW7	0.931	More...
Q13261	Interleukin-15 receptor subunit alpha	DEG_SCF_FBW7_2	115:120	VTPQPE	FBXW7	0.959	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons