DegronMD

Uniprot ID: O95273

Source protein: Cyclin-D1-binding protein 1

Source gene: CCNDBP1

Class: DEG_SCF_FBW7_2

Location: 327:332

E3 ligase: FBXW7

DEGRON score: 0.6252

ASA_SCORE: 84.15

COIL: 0.8382

CONS_SCORE: 0.4849

DSS_SCORE: 0.2441

HELIX: 0.1413

FCONS_SCORE: 0.7965

RIG_SCORE: 0.7332

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P329T	TCGA-DA-A1IB	SKCM	TCGA	VTPQPE	DEG_SCF_FBW7_2	0.7031
p.S325R	TCGA-35-4122	LUAD	TCGA	VTPQPE	DEG_SCF_FBW7_2	0.2778
p.E320K	TCGA-A1-A0SI	BRCA	TCGA	VTPQPE	DEG_SCF_FBW7_2	0.1389
p.E320K	DO1774	BRCA	ICGC	VTPQPE	DEG_SCF_FBW7_2	0.1389
p.L319V	SIDM01016	T-Lymphoblastic Leukemia	GDSC	VTPQPE	DEG_SCF_FBW7_2	0.1111
p.L319V	ACH-000995	Leukemia	CCLE	VTPQPE	DEG_SCF_FBW7_2	0.1111

Showing 1 to 6 of 6 entries

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O95273	Cyclin-D1-binding protein 1	DEG_SCF_FBW7_2	327:332	VTPQPE	FBXW7	0.6252	More...
Q13261	Interleukin-15 receptor subunit alpha	DEG_SCF_FBW7_2	115:120	VTPQPE	FBXW7	0.959	More...
P01589	Interleukin-2 receptor subunit alpha	DEG_SCF_FBW7_2	94:99	VTPQPE	FBXW7	0.931	More...

Showing 1 to 3 of 3 entries

DegronMD: protein-targeted degradation, mutation and drug response to degrons