DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
VTPQPE
Uniprot ID:
O95273
Source protein:
Cyclin-D1-binding protein 1
Source gene:
CCNDBP1
Class:
DEG_SCF_FBW7_2
Location:
327:332
E3 ligase:
FBXW7
DEGRON score:
0.6252
ASA_SCORE:
84.15
COIL:
0.8382
CONS_SCORE:
0.4849
DSS_SCORE:
0.2441
HELIX:
0.1413
FCONS_SCORE:
0.7965
RIG_SCORE:
0.7332
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.S325R
TCGA-35-4122
LUAD
TCGA
VTPQPE
DEG_SCF_FBW7_2
0.2778
p.E320K
TCGA-A1-A0SI
BRCA
TCGA
VTPQPE
DEG_SCF_FBW7_2
0.1389
p.E320K
DO1774
BRCA
ICGC
VTPQPE
DEG_SCF_FBW7_2
0.1389
p.P329T
TCGA-DA-A1IB
SKCM
TCGA
VTPQPE
DEG_SCF_FBW7_2
0.7031
p.L319V
SIDM01016
T-Lymphoblastic Leukemia
GDSC
VTPQPE
DEG_SCF_FBW7_2
0.1111
p.L319V
ACH-000995
Leukemia
CCLE
VTPQPE
DEG_SCF_FBW7_2
0.1111
Drug responses associated with CCNDBP1 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of VTPQPE
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
O95273
Cyclin-D1-binding protein 1
DEG_SCF_FBW7_2
327:332
VTPQPE
FBXW7
0.6252
More...
P01589
Interleukin-2 receptor subunit alpha
DEG_SCF_FBW7_2
94:99
VTPQPE
FBXW7
0.931
More...
Q13261
Interleukin-15 receptor subunit alpha
DEG_SCF_FBW7_2
115:120
VTPQPE
FBXW7
0.959
More...