DegronMD

Uniprot ID: Q13261

Source protein: Interleukin-15 receptor subunit alpha

Source gene: IL15RA

Class: DEG_SCF_FBW7_2

Location: 115:120

E3 ligase: FBXW7

DEGRON score: 0.959

ASA_SCORE: 94.5

COIL: 0.9158

CONS_SCORE: 0.8367

DSS_SCORE: 0.7012

HELIX: 0.0308

FCONS_SCORE: 1.0961

RIG_SCORE: 0.626

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P128L	DO223732	CESC	ICGC	VTPQPE	DEG_SCF_FBW7_2	0.1111
p.P128L	DO41235	UCEC	ICGC	VTPQPE	DEG_SCF_FBW7_2	0.1111
p.Q112E	DO6254	CESC	ICGC	VTPQPE	DEG_SCF_FBW7_2	0.25
p.A109S	DO223371	CLLE	ICGC	VTPQPE	DEG_SCF_FBW7_2	0.1667
p.N117T	DO229013	COCA	ICGC	VTPQPE	DEG_SCF_FBW7_2	0.7055
p.N117T	DO229003	COCA	ICGC	VTPQPE	DEG_SCF_FBW7_2	0.7055
p.N117T	DO229005	COCA	ICGC	VTPQPE	DEG_SCF_FBW7_2	0.7055
p.N117T	DO234285	ESAD	ICGC	VTPQPE	DEG_SCF_FBW7_2	0.7055
p.N117T	DO230942	LUSC	ICGC	VTPQPE	DEG_SCF_FBW7_2	0.7055
p.N117T	DO230990	LUSC	ICGC	VTPQPE	DEG_SCF_FBW7_2	0.7055
p.H107N	DO229034	LICA	ICGC	VTPQPE	DEG_SCF_FBW7_2	0.1111
p.H107Q	DO229036	LICA	ICGC	VTPQPE	DEG_SCF_FBW7_2	0.1111
p.P128Q	DO229035	LICA	ICGC	VTPQPE	DEG_SCF_FBW7_2	0.1111
p.K116N	DO36556	READ	ICGC	VTPQPE	DEG_SCF_FBW7_2	0.6918
p.E119K	DO37731	SKCM	ICGC	VTPQPE	DEG_SCF_FBW7_2	0.7022
p.P128S	DO47623	SKCM	ICGC	VTPQPE	DEG_SCF_FBW7_2	0.1111
p.H107Y	DO38001	SKCM	ICGC	VTPQPE	DEG_SCF_FBW7_2	0.1111
p.S105F	DO219501	SKCM	ICGC	VTPQPE	DEG_SCF_FBW7_2	0.0556
p.H126N	DO48044	STAD	ICGC	VTPQPE	DEG_SCF_FBW7_2	0.1667
p.P124H	ACH-002288	Embryonal Cancer	CCLE	VTPQPE	DEG_SCF_FBW7_2	0.2222
p.P124H	NEC8	testis	COSMIC	VTPQPE	DEG_SCF_FBW7_2	0.2222
p.V127M	NOS-1	bone	COSMIC	VTPQPE	DEG_SCF_FBW7_2	0.25
p.V127M	SNU-1040	large_intestine	COSMIC	VTPQPE	DEG_SCF_FBW7_2	0.25
p.V127M	SNU-C1	large_intestine	COSMIC	VTPQPE	DEG_SCF_FBW7_2	0.25
p.V127M	RERF-LC-KJ	lung	COSMIC	VTPQPE	DEG_SCF_FBW7_2	0.25
p.V127M	SKG-IIIa	cervix	COSMIC	VTPQPE	DEG_SCF_FBW7_2	0.25
p.C110Y	HCT-116	large_intestine	COSMIC	VTPQPE	DEG_SCF_FBW7_2	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O95273	Cyclin-D1-binding protein 1	DEG_SCF_FBW7_2	327:332	VTPQPE	FBXW7	0.6252	More...
P01589	Interleukin-2 receptor subunit alpha	DEG_SCF_FBW7_2	94:99	VTPQPE	FBXW7	0.931	More...
Q13261	Interleukin-15 receptor subunit alpha	DEG_SCF_FBW7_2	115:120	VTPQPE	FBXW7	0.959	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons