DegronMD - Q13261(IL15RA)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P128L	DO223732	CESC	ICGC	VTPQPE	DEG_SCF_FBW7_2	115:120	Mutation rewiring degron network	0.1111
p.P128L	DO41235	UCEC	ICGC	VTPQPE	DEG_SCF_FBW7_2	115:120	Mutation rewiring degron network	0.1111
p.Q112E	DO6254	CESC	ICGC	VTPQPE	DEG_SCF_FBW7_2	115:120	Mutation rewiring degron network	0.25
p.A109S	DO223371	CLLE	ICGC	VTPQPE	DEG_SCF_FBW7_2	115:120	Mutation rewiring degron network	0.1667
p.N117T	DO229013	COCA	ICGC	VTPQPE	DEG_SCF_FBW7_2	115:120	Mutation altering degron motif	0.7055
p.N117T	DO229003	COCA	ICGC	VTPQPE	DEG_SCF_FBW7_2	115:120	Mutation altering degron motif	0.7055
p.N117T	DO229005	COCA	ICGC	VTPQPE	DEG_SCF_FBW7_2	115:120	Mutation altering degron motif	0.7055
p.N117T	DO234285	ESAD	ICGC	VTPQPE	DEG_SCF_FBW7_2	115:120	Mutation altering degron motif	0.7055
p.N117T	DO230942	LUSC	ICGC	VTPQPE	DEG_SCF_FBW7_2	115:120	Mutation altering degron motif	0.7055
p.N117T	DO230990	LUSC	ICGC	VTPQPE	DEG_SCF_FBW7_2	115:120	Mutation altering degron motif	0.7055
p.H107N	DO229034	LICA	ICGC	VTPQPE	DEG_SCF_FBW7_2	115:120	Mutation rewiring degron network	0.1111
p.H107Q	DO229036	LICA	ICGC	VTPQPE	DEG_SCF_FBW7_2	115:120	Mutation rewiring degron network	0.1111
p.P128Q	DO229035	LICA	ICGC	VTPQPE	DEG_SCF_FBW7_2	115:120	Mutation rewiring degron network	0.1111
p.K116N	DO36556	READ	ICGC	VTPQPE	DEG_SCF_FBW7_2	115:120	Mutation altering degron motif	0.6918
p.E119K	DO37731	SKCM	ICGC	VTPQPE	DEG_SCF_FBW7_2	115:120	Mutation altering degron motif	0.7022
p.P128S	DO47623	SKCM	ICGC	VTPQPE	DEG_SCF_FBW7_2	115:120	Mutation rewiring degron network	0.1111
p.H107Y	DO38001	SKCM	ICGC	VTPQPE	DEG_SCF_FBW7_2	115:120	Mutation rewiring degron network	0.1111
p.S105F	DO219501	SKCM	ICGC	VTPQPE	DEG_SCF_FBW7_2	115:120	Mutation rewiring degron network	0.0556
p.H126N	DO48044	STAD	ICGC	VTPQPE	DEG_SCF_FBW7_2	115:120	Mutation rewiring degron network	0.1667
p.P124H	ACH-002288	Embryonal Cancer	CCLE	VTPQPE	DEG_SCF_FBW7_2	115:120	Mutation rewiring degron network	0.2222
p.P124H	NEC8	testis	COSMIC	VTPQPE	DEG_SCF_FBW7_2	115:120	Mutation rewiring degron network	0.2222
p.V127M	NOS-1	bone	COSMIC	VTPQPE	DEG_SCF_FBW7_2	115:120	Mutation substituting flanking lysine	0.25
p.V127M	SNU-1040	large intestine	COSMIC	VTPQPE	DEG_SCF_FBW7_2	115:120	Mutation substituting flanking lysine	0.25
p.V127M	SNU-C1	large intestine	COSMIC	VTPQPE	DEG_SCF_FBW7_2	115:120	Mutation substituting flanking lysine	0.25
p.V127M	RERF-LC-KJ	lung	COSMIC	VTPQPE	DEG_SCF_FBW7_2	115:120	Mutation substituting flanking lysine	0.25
p.V127M	SKG-IIIa	cervix	COSMIC	VTPQPE	DEG_SCF_FBW7_2	115:120	Mutation substituting flanking lysine	0.25
p.C110Y	HCT-116	large intestine	COSMIC	VTPQPE	DEG_SCF_FBW7_2	115:120	Mutation rewiring degron network	0.1944

Kaplan plot for IL15RA in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

IL15RA

UniProt ID: Q13261

Entrez ID: 3601

Protein name: Interleukin-15 receptor subunit alpha (IL-15 receptor subunit alpha) (IL-15R-alpha) (IL-15RA) (CD antigen CD215) [Cleaved into: Soluble interleukin-15 receptor subunit alpha (sIL-15 receptor subunit alpha) (sIL-15R-alpha) (sIL-15RA)]

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for IL15RA in