DegronMD - P01732(CD8A)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S154L	TCGA-EO-A22R	UCEC	TCGA	PPTPAPT	DEG_SCF_FBW7_1	145:151	Mutation rewiring degron network	0.25
p.S154L	DO42713	UCEC	ICGC	PPTPAPT	DEG_SCF_FBW7_1	145:151	Mutation rewiring degron network	0.25
p.A150S	DO5870	BRCA	ICGC	PPTPAPT	DEG_SCF_FBW7_1	145:151	Mutation altering degron motif	0.7588
p.A153V	DO222877	COCA	ICGC	PPTPAPT	DEG_SCF_FBW7_1	145:151	Mutation rewiring degron network	0.2778
p.I146M	DO10858	ESAD	ICGC	PPTPAPT	DEG_SCF_FBW7_1	145:151	Mutation altering degron motif	0.7618
p.T137M	DO234446	ESAD	ICGC	PPTPAPT	DEG_SCF_FBW7_1	145:151	Mutation rewiring degron network	0.1111
p.T137M	DO41109	UCEC	ICGC	PPTPAPT	DEG_SCF_FBW7_1	145:151	Mutation rewiring degron network	0.1111
p.T137K	DO229018	LICA	ICGC	PPTPAPT	DEG_SCF_FBW7_1	145:151	Mutation rewiring degron network	0.1111
p.A153D	DO229018	LICA	ICGC	PPTPAPT	DEG_SCF_FBW7_1	145:151	Mutation rewiring degron network	0.2778
p.H136Q	DO229019	LICA	ICGC	PPTPAPT	DEG_SCF_FBW7_1	145:151	Mutation substituting flanking lysine	0.1944
p.S158Y	DO229030	LICA	ICGC	PPTPAPT	DEG_SCF_FBW7_1	145:151	Mutation rewiring degron network	0.1389
p.G154R	DO46362	OV	ICGC	PPTPAPT	DEG_SCF_FBW7_1	145:151	Mutation rewiring degron network	0.25
p.D145Y	DO38887	STAD	ICGC	PPTPAPT	DEG_SCF_FBW7_1	145:151	Mutation altering degron motif	0.7325
p.Y147C	DO38711	STAD	ICGC	PPTPAPT	DEG_SCF_FBW7_1	145:151	Mutation altering degron motif	0.7087
p.P156S	SIDM02021	Esophageal Carcinoma	GDSC	PPTPAPT	DEG_SCF_FBW7_1	145:151	Mutation rewiring degron network	0.1944
p.S158F	ACH-000021	Lung Cancer	CCLE	PPTPAPT	DEG_SCF_FBW7_1	145:151	Mutation rewiring degron network	0.1389

Kaplan plot for CD8A in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

CD8A

UniProt ID: P01732

Entrez ID: 925

Protein name: T-cell surface glycoprotein CD8 alpha chain (T-lymphocyte differentiation antigen T8/Leu-2) (CD antigen CD8a)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for CD8A in