DegronMD

Uniprot ID: P01732

Source protein: T-cell surface glycoprotein CD8 alpha chain

Source gene: CD8A

Class: DEG_SCF_FBW7_1

Location: 145:151

E3 ligase: FBXW7

DEGRON score: 0.668

ASA_SCORE: 88.1286

COIL: 0.9549

CONS_SCORE: 0.3565

DSS_SCORE: 0.6894

HELIX: 0.017

FCONS_SCORE: 0.799

RIG_SCORE: 0.6488

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S154L	TCGA-EO-A22R	UCEC	TCGA	PPTPAPT	DEG_SCF_FBW7_1	0.25
p.S154L	DO42713	UCEC	ICGC	PPTPAPT	DEG_SCF_FBW7_1	0.25
p.A150S	DO5870	BRCA	ICGC	PPTPAPT	DEG_SCF_FBW7_1	0.7588
p.A153V	DO222877	COCA	ICGC	PPTPAPT	DEG_SCF_FBW7_1	0.2778
p.I146M	DO10858	ESAD	ICGC	PPTPAPT	DEG_SCF_FBW7_1	0.7618
p.T137M	DO234446	ESAD	ICGC	PPTPAPT	DEG_SCF_FBW7_1	0.1111
p.T137M	DO41109	UCEC	ICGC	PPTPAPT	DEG_SCF_FBW7_1	0.1111
p.T137K	DO229018	LICA	ICGC	PPTPAPT	DEG_SCF_FBW7_1	0.1111
p.A153D	DO229018	LICA	ICGC	PPTPAPT	DEG_SCF_FBW7_1	0.2778
p.H136Q	DO229019	LICA	ICGC	PPTPAPT	DEG_SCF_FBW7_1	0.1944
p.S158Y	DO229030	LICA	ICGC	PPTPAPT	DEG_SCF_FBW7_1	0.1389
p.G154R	DO46362	OV	ICGC	PPTPAPT	DEG_SCF_FBW7_1	0.25
p.D145Y	DO38887	STAD	ICGC	PPTPAPT	DEG_SCF_FBW7_1	0.7325
p.Y147C	DO38711	STAD	ICGC	PPTPAPT	DEG_SCF_FBW7_1	0.7087
p.P156S	SIDM02021	Esophageal Carcinoma	GDSC	PPTPAPT	DEG_SCF_FBW7_1	0.1944
p.S158F	ACH-000021	Lung Cancer	CCLE	PPTPAPT	DEG_SCF_FBW7_1	0.1389

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O00401	Neural Wiskott-Aldrich syndrome protein	DEG_SCF_FBW7_1	458:464	PPTPAPT	FBXW7	0.9785	More...
P01732	T-cell surface glycoprotein CD8 alpha chain	DEG_SCF_FBW7_1	145:151	PPTPAPT	FBXW7	0.668	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons