DegronMD

Uniprot ID: O00401

Source protein: Neural Wiskott-Aldrich syndrome protein

Source gene: WASL

Class: DEG_SCF_FBW7_1

Location: 458:464

E3 ligase: FBXW7

DEGRON score: 0.9785

ASA_SCORE: 87.6286

COIL: 0.952

CONS_SCORE: 0.3468

DSS_SCORE: 0.7241

HELIX: 0.0234

FCONS_SCORE: 0.7392

RIG_SCORE: 0.6173

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S449Y	TCGA-86-8073	LUAD	TCGA	PPTPAPT	DEG_SCF_FBW7_1	0.0833
p.S449Y	DO23624	LUAD	ICGC	PPTPAPT	DEG_SCF_FBW7_1	0.0833
p.E455V	TCGA-C5-A7UE	CESC	TCGA	PPTPAPT	DEG_SCF_FBW7_1	0.25
p.E455V	DO49890	CESC	ICGC	PPTPAPT	DEG_SCF_FBW7_1	0.25
p.A470T	TCGA-EO-A22U	UCEC	TCGA	PPTPAPT	DEG_SCF_FBW7_1	0.1667
p.A470T	DO43755	UCEC	ICGC	PPTPAPT	DEG_SCF_FBW7_1	0.1667
p.I467T	TCGA-UZ-A9PV	KIRP	TCGA	PPTPAPT	DEG_SCF_FBW7_1	0.25
p.I467T	DO219711	KIRP	ICGC	PPTPAPT	DEG_SCF_FBW7_1	0.25
p.V468A	DO230334	COCA	ICGC	PPTPAPT	DEG_SCF_FBW7_1	0.2222
p.S465L	DO233151	GACA	ICGC	PPTPAPT	DEG_SCF_FBW7_1	0.3056
p.T464N	DO228974	LICA	ICGC	PPTPAPT	DEG_SCF_FBW7_1	0.8166
p.G453C	DO229211	THCA	ICGC	PPTPAPT	DEG_SCF_FBW7_1	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O00401	Neural Wiskott-Aldrich syndrome protein	DEG_SCF_FBW7_1	458:464	PPTPAPT	FBXW7	0.9785	More...
P01732	T-cell surface glycoprotein CD8 alpha chain	DEG_SCF_FBW7_1	145:151	PPTPAPT	FBXW7	0.668	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons