DegronMD - P01857(IGHG1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.E141K	TCGA-44-A47F	LUAD	TCGA	ISRTPEVT	DEG_SCF_FBW7_1	136:143	Mutation altering degron motif	0.591
p.E141K	TCGA-BR-A4PD	STAD	TCGA	ISRTPEVT	DEG_SCF_FBW7_1	136:143	Mutation altering degron motif	0.591
p.E141K	DO24180	LUAD	ICGC	ISRTPEVT	DEG_SCF_FBW7_1	136:143	Mutation altering degron motif	0.591
p.E141K	DO47831	STAD	ICGC	ISRTPEVT	DEG_SCF_FBW7_1	136:143	Mutation altering degron motif	0.591
p.E152K	TCGA-4W-AA9R	GBM	TCGA	ISRTPEVT	DEG_SCF_FBW7_1	136:143	Mutation rewiring degron network	0.0833
p.E152K	TCGA-HC-7230	PRAD	TCGA	ISRTPEVT	DEG_SCF_FBW7_1	136:143	Mutation rewiring degron network	0.0833
p.E152K	DO219107	GBM	ICGC	ISRTPEVT	DEG_SCF_FBW7_1	136:143	Mutation rewiring degron network	0.0833
p.E152K	DO36363	PRAD	ICGC	ISRTPEVT	DEG_SCF_FBW7_1	136:143	Mutation rewiring degron network	0.0833
p.D148A	TCGA-A4-A772	KIRP	TCGA	ISRTPEVT	DEG_SCF_FBW7_1	136:143	Mutation rewiring degron network	0.1944
p.D148A	DO49727	KIRP	ICGC	ISRTPEVT	DEG_SCF_FBW7_1	136:143	Mutation rewiring degron network	0.1944
p.D148G	TCGA-AJ-A3EL	UCEC	TCGA	ISRTPEVT	DEG_SCF_FBW7_1	136:143	Mutation rewiring degron network	0.1944
p.D148G	DO41542	UCEC	ICGC	ISRTPEVT	DEG_SCF_FBW7_1	136:143	Mutation rewiring degron network	0.1944
p.T139I	TCGA-BR-7717	STAD	TCGA	ISRTPEVT	DEG_SCF_FBW7_1	136:143	Mutation altering degron motif	0.7078
p.T139I	DO38412	STAD	ICGC	ISRTPEVT	DEG_SCF_FBW7_1	136:143	Mutation altering degron motif	0.7078
p.R138Q	TCGA-BR-8680	STAD	TCGA	ISRTPEVT	DEG_SCF_FBW7_1	136:143	Mutation altering degron motif	0.6218
p.R138Q	TCGA-ZF-AA5P	BLCA	TCGA	ISRTPEVT	DEG_SCF_FBW7_1	136:143	Mutation altering degron motif	0.6218
p.R138Q	DO219103	BLCA	ICGC	ISRTPEVT	DEG_SCF_FBW7_1	136:143	Mutation altering degron motif	0.6218
p.R138Q	DO47769	STAD	ICGC	ISRTPEVT	DEG_SCF_FBW7_1	136:143	Mutation altering degron motif	0.6218
p.P130S	TCGA-CA-6718	COAD	TCGA	ISRTPEVT	DEG_SCF_FBW7_1	136:143	Mutation rewiring degron network	0.1667
p.P130S	TCGA-FF-A7CQ	DLBC	TCGA	ISRTPEVT	DEG_SCF_FBW7_1	136:143	Mutation rewiring degron network	0.1667
p.P130S	DO7801	COAD	ICGC	ISRTPEVT	DEG_SCF_FBW7_1	136:143	Mutation rewiring degron network	0.1667
p.P130S	DO219893	DLBC	ICGC	ISRTPEVT	DEG_SCF_FBW7_1	136:143	Mutation rewiring degron network	0.1667
p.P130S	DO228605	MALY	ICGC	ISRTPEVT	DEG_SCF_FBW7_1	136:143	Mutation rewiring degron network	0.1667
p.K131R	TCGA-D3-A1Q6	SKCM	TCGA	ISRTPEVT	DEG_SCF_FBW7_1	136:143	Mutation substituting flanking lysine	0.3056
p.K131R	DO37450	SKCM	ICGC	ISRTPEVT	DEG_SCF_FBW7_1	136:143	Mutation substituting flanking lysine	0.3056
p.M135I	TCGA-D3-A8GM	SKCM	TCGA	ISRTPEVT	DEG_SCF_FBW7_1	136:143	Mutation rewiring degron network	0.3056
p.M135I	TCGA-FW-A5DX	SKCM	TCGA	ISRTPEVT	DEG_SCF_FBW7_1	136:143	Mutation rewiring degron network	0.3056
p.M135I	DO47253	SKCM	ICGC	ISRTPEVT	DEG_SCF_FBW7_1	136:143	Mutation rewiring degron network	0.3056
p.M135I	DO50288	SKCM	ICGC	ISRTPEVT	DEG_SCF_FBW7_1	136:143	Mutation rewiring degron network	0.3056
p.T133A	TCGA-DF-A2KU	UCEC	TCGA	ISRTPEVT	DEG_SCF_FBW7_1	136:143	Mutation blocking phosphorylation signal	0.6944
p.T133A	DO223286	UCEC	ICGC	ISRTPEVT	DEG_SCF_FBW7_1	136:143	Mutation blocking phosphorylation signal	0.6944
p.P127L	TCGA-EE-A183	SKCM	TCGA	ISRTPEVT	DEG_SCF_FBW7_1	136:143	Mutation rewiring degron network	0.0833
p.P127L	DO37715	SKCM	ICGC	ISRTPEVT	DEG_SCF_FBW7_1	136:143	Mutation rewiring degron network	0.0833
p.P140H	TCGA-NC-A5HE	LUSC	TCGA	ISRTPEVT	DEG_SCF_FBW7_1	136:143	Mutation altering degron motif	0.7694
p.P140H	DO45453	LUSC	ICGC	ISRTPEVT	DEG_SCF_FBW7_1	136:143	Mutation altering degron motif	0.7694
p.E152G	TCGA-VR-A8EW	ESCA	TCGA	ISRTPEVT	DEG_SCF_FBW7_1	136:143	Mutation rewiring degron network	0.0833
p.V147M	TCGA-W3-AA1V	SKCM	TCGA	ISRTPEVT	DEG_SCF_FBW7_1	136:143	Mutation rewiring degron network	0.2222
p.V147M	DO51276	SKCM	ICGC	ISRTPEVT	DEG_SCF_FBW7_1	136:143	Mutation rewiring degron network	0.2222
p.R138W	DO227986	COCA	ICGC	ISRTPEVT	DEG_SCF_FBW7_1	136:143	Mutation altering degron motif	0.7523
p.E152Q	DO222309	DLBC	ICGC	ISRTPEVT	DEG_SCF_FBW7_1	136:143	Mutation rewiring degron network	0.0833
p.D153E	DO45117	LIRI	ICGC	ISRTPEVT	DEG_SCF_FBW7_1	136:143	Mutation rewiring degron network	0.0556
p.V142I	DO228451	MALY	ICGC	ISRTPEVT	DEG_SCF_FBW7_1	136:143	Mutation altering degron motif	0.5965
p.T133I	DO228424	MALY	ICGC	ISRTPEVT	DEG_SCF_FBW7_1	136:143	Mutation blocking phosphorylation signal	0.6944
p.C144Y	DO228424	MALY	ICGC	ISRTPEVT	DEG_SCF_FBW7_1	136:143	Mutation rewiring degron network	0.3056
p.S137F	DO222546	MELA	ICGC	ISRTPEVT	DEG_SCF_FBW7_1	136:143	Mutation altering degron motif	0.7982
p.V145M	DO229139	NKTL	ICGC	ISRTPEVT	DEG_SCF_FBW7_1	136:143	Mutation rewiring degron network	0.2778

Kaplan plot for IGHG1 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

IGHG1

UniProt ID: P01857

Entrez ID:

Protein name: Immunoglobulin heavy constant gamma 1 (Ig gamma-1 chain C region) (Ig gamma-1 chain C region EU) (Ig gamma-1 chain C region KOL) (Ig gamma-1 chain C region NIE)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for IGHG1 in