DegronMD

Uniprot ID: P01857

Source protein: Immunoglobulin heavy constant gamma 1

Source gene: IGHG1

Class: DEG_SCF_FBW7_1

Location: 136:143

E3 ligase: FBXW7

DEGRON score: 0.9288

ASA_SCORE: 63.975

COIL: 0.6161

CONS_SCORE: 0.3581

DSS_SCORE: 0.2664

HELIX: 0.0283

FCONS_SCORE: 0.8172

RIG_SCORE: 0.8185

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E141K	TCGA-44-A47F	LUAD	TCGA	ISRTPEVT	DEG_SCF_FBW7_1	0.591
p.E141K	TCGA-BR-A4PD	STAD	TCGA	ISRTPEVT	DEG_SCF_FBW7_1	0.591
p.E141K	DO24180	LUAD	ICGC	ISRTPEVT	DEG_SCF_FBW7_1	0.591
p.E141K	DO47831	STAD	ICGC	ISRTPEVT	DEG_SCF_FBW7_1	0.591
p.E152K	TCGA-4W-AA9R	GBM	TCGA	ISRTPEVT	DEG_SCF_FBW7_1	0.0833
p.E152K	TCGA-HC-7230	PRAD	TCGA	ISRTPEVT	DEG_SCF_FBW7_1	0.0833
p.E152K	DO219107	GBM	ICGC	ISRTPEVT	DEG_SCF_FBW7_1	0.0833
p.E152K	DO36363	PRAD	ICGC	ISRTPEVT	DEG_SCF_FBW7_1	0.0833
p.D148A	TCGA-A4-A772	KIRP	TCGA	ISRTPEVT	DEG_SCF_FBW7_1	0.1944
p.D148A	DO49727	KIRP	ICGC	ISRTPEVT	DEG_SCF_FBW7_1	0.1944
p.D148G	TCGA-AJ-A3EL	UCEC	TCGA	ISRTPEVT	DEG_SCF_FBW7_1	0.1944
p.D148G	DO41542	UCEC	ICGC	ISRTPEVT	DEG_SCF_FBW7_1	0.1944
p.T139I	TCGA-BR-7717	STAD	TCGA	ISRTPEVT	DEG_SCF_FBW7_1	0.7078
p.T139I	DO38412	STAD	ICGC	ISRTPEVT	DEG_SCF_FBW7_1	0.7078
p.R138Q	TCGA-BR-8680	STAD	TCGA	ISRTPEVT	DEG_SCF_FBW7_1	0.6218
p.R138Q	TCGA-ZF-AA5P	BLCA	TCGA	ISRTPEVT	DEG_SCF_FBW7_1	0.6218
p.R138Q	DO219103	BLCA	ICGC	ISRTPEVT	DEG_SCF_FBW7_1	0.6218
p.R138Q	DO47769	STAD	ICGC	ISRTPEVT	DEG_SCF_FBW7_1	0.6218
p.P130S	TCGA-CA-6718	COAD	TCGA	ISRTPEVT	DEG_SCF_FBW7_1	0.1667
p.P130S	TCGA-FF-A7CQ	DLBC	TCGA	ISRTPEVT	DEG_SCF_FBW7_1	0.1667
p.P130S	DO7801	COAD	ICGC	ISRTPEVT	DEG_SCF_FBW7_1	0.1667
p.P130S	DO219893	DLBC	ICGC	ISRTPEVT	DEG_SCF_FBW7_1	0.1667
p.P130S	DO228605	MALY	ICGC	ISRTPEVT	DEG_SCF_FBW7_1	0.1667
p.K131R	TCGA-D3-A1Q6	SKCM	TCGA	ISRTPEVT	DEG_SCF_FBW7_1	0.3056
p.K131R	DO37450	SKCM	ICGC	ISRTPEVT	DEG_SCF_FBW7_1	0.3056
p.M135I	TCGA-D3-A8GM	SKCM	TCGA	ISRTPEVT	DEG_SCF_FBW7_1	0.3056
p.M135I	TCGA-FW-A5DX	SKCM	TCGA	ISRTPEVT	DEG_SCF_FBW7_1	0.3056
p.M135I	DO47253	SKCM	ICGC	ISRTPEVT	DEG_SCF_FBW7_1	0.3056
p.M135I	DO50288	SKCM	ICGC	ISRTPEVT	DEG_SCF_FBW7_1	0.3056
p.T133A	TCGA-DF-A2KU	UCEC	TCGA	ISRTPEVT	DEG_SCF_FBW7_1	0.6944
p.T133A	DO223286	UCEC	ICGC	ISRTPEVT	DEG_SCF_FBW7_1	0.6944
p.P127L	TCGA-EE-A183	SKCM	TCGA	ISRTPEVT	DEG_SCF_FBW7_1	0.0833
p.P127L	DO37715	SKCM	ICGC	ISRTPEVT	DEG_SCF_FBW7_1	0.0833
p.P140H	TCGA-NC-A5HE	LUSC	TCGA	ISRTPEVT	DEG_SCF_FBW7_1	0.7694
p.P140H	DO45453	LUSC	ICGC	ISRTPEVT	DEG_SCF_FBW7_1	0.7694
p.E152G	TCGA-VR-A8EW	ESCA	TCGA	ISRTPEVT	DEG_SCF_FBW7_1	0.0833
p.V147M	TCGA-W3-AA1V	SKCM	TCGA	ISRTPEVT	DEG_SCF_FBW7_1	0.2222
p.V147M	DO51276	SKCM	ICGC	ISRTPEVT	DEG_SCF_FBW7_1	0.2222
p.R138W	DO227986	COCA	ICGC	ISRTPEVT	DEG_SCF_FBW7_1	0.7523
p.E152Q	DO222309	DLBC	ICGC	ISRTPEVT	DEG_SCF_FBW7_1	0.0833
p.D153E	DO45117	LIRI	ICGC	ISRTPEVT	DEG_SCF_FBW7_1	0.0556
p.V142I	DO228451	MALY	ICGC	ISRTPEVT	DEG_SCF_FBW7_1	0.5965
p.T133I	DO228424	MALY	ICGC	ISRTPEVT	DEG_SCF_FBW7_1	0.6944
p.C144Y	DO228424	MALY	ICGC	ISRTPEVT	DEG_SCF_FBW7_1	0.3056
p.S137F	DO222546	MELA	ICGC	ISRTPEVT	DEG_SCF_FBW7_1	0.7982
p.V145M	DO229139	NKTL	ICGC	ISRTPEVT	DEG_SCF_FBW7_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P01857	Immunoglobulin heavy constant gamma 1	DEG_SCF_FBW7_1	136:143	ISRTPEVT	FBXW7	0.9288	More...
P01859	Immunoglobulin heavy constant gamma 2	DEG_SCF_FBW7_1	132:139	ISRTPEVT	FBXW7	0.7165	More...
P01860	Immunoglobulin heavy constant gamma 3	DEG_SCF_FBW7_1	183:190	ISRTPEVT	FBXW7	0.8894	More...
P01861	Immunoglobulin heavy constant gamma 4	DEG_SCF_FBW7_1	133:140	ISRTPEVT	FBXW7	0.7507	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: ISRTPEVT

Degron related mutations and impact score

Drug responses associated with IGHG1 mutations

All proteins holding degron of ISRTPEVT