DegronMD

Uniprot ID: P01860

Source protein: Immunoglobulin heavy constant gamma 3

Source gene: IGHG3

Class: DEG_SCF_FBW7_1

Location: 183:190

E3 ligase: FBXW7

DEGRON score: 0.8894

ASA_SCORE: 69.675

COIL: 0.6353

CONS_SCORE: 0.5289

DSS_SCORE: 0.267

HELIX: 0.0729

FCONS_SCORE: 0.8543

RIG_SCORE: 0.8153

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.V192M	TCGA-AF-3911	READ	TCGA	ISRTPEVT	DEG_SCF_FBW7_1	0.2778
p.D200H	TCGA-C5-A1M8	CESC	TCGA	ISRTPEVT	DEG_SCF_FBW7_1	0.0556
p.M182I	TCGA-D3-A1QB	SKCM	TCGA	ISRTPEVT	DEG_SCF_FBW7_1	0.3056
p.M182I	TCGA-FS-A1ZZ	SKCM	TCGA	ISRTPEVT	DEG_SCF_FBW7_1	0.3056
p.M182I	TCGA-WE-A8K5	SKCM	TCGA	ISRTPEVT	DEG_SCF_FBW7_1	0.3056
p.S184F	TCGA-DA-A95Z	SKCM	TCGA	ISRTPEVT	DEG_SCF_FBW7_1	0.7982
p.E188K	TCGA-DS-A1OC	CESC	TCGA	ISRTPEVT	DEG_SCF_FBW7_1	0.591
p.D179N	TCGA-EE-A2GR	SKCM	TCGA	ISRTPEVT	DEG_SCF_FBW7_1	0.2222
p.L181F	TCGA-ER-A194	SKCM	TCGA	ISRTPEVT	DEG_SCF_FBW7_1	0.2778
p.E199K	TCGA-W3-AA21	SKCM	TCGA	ISRTPEVT	DEG_SCF_FBW7_1	0.0833
p.D199H	DO48993	CESC	ICGC	ISRTPEVT	DEG_SCF_FBW7_1	0.0833
p.E187K	DO6329	CESC	ICGC	ISRTPEVT	DEG_SCF_FBW7_1	0.7022
p.R184Q	DO50323	ESAD	ICGC	ISRTPEVT	DEG_SCF_FBW7_1	0.7329
p.S183F	DO220874	MELA	ICGC	ISRTPEVT	DEG_SCF_FBW7_1	0.7982
p.S183F	DO219481	SKCM	ICGC	ISRTPEVT	DEG_SCF_FBW7_1	0.7982
p.D199N	DO222532	MELA	ICGC	ISRTPEVT	DEG_SCF_FBW7_1	0.0833
p.E198K	DO35539	PBCA	ICGC	ISRTPEVT	DEG_SCF_FBW7_1	0.1111
p.E198K	DO218896	SKCA	ICGC	ISRTPEVT	DEG_SCF_FBW7_1	0.1111
p.E198K	DO51278	SKCM	ICGC	ISRTPEVT	DEG_SCF_FBW7_1	0.1111
p.M181I	DO37412	SKCM	ICGC	ISRTPEVT	DEG_SCF_FBW7_1	0.2778
p.M181I	DO47573	SKCM	ICGC	ISRTPEVT	DEG_SCF_FBW7_1	0.2778
p.M181I	DO51282	SKCM	ICGC	ISRTPEVT	DEG_SCF_FBW7_1	0.2778
p.D178N	DO37996	SKCM	ICGC	ISRTPEVT	DEG_SCF_FBW7_1	0.3056
p.L180F	DO47646	SKCM	ICGC	ISRTPEVT	DEG_SCF_FBW7_1	0.6944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P01857	Immunoglobulin heavy constant gamma 1	DEG_SCF_FBW7_1	136:143	ISRTPEVT	FBXW7	0.9288	More...
P01859	Immunoglobulin heavy constant gamma 2	DEG_SCF_FBW7_1	132:139	ISRTPEVT	FBXW7	0.7165	More...
P01860	Immunoglobulin heavy constant gamma 3	DEG_SCF_FBW7_1	183:190	ISRTPEVT	FBXW7	0.8894	More...
P01861	Immunoglobulin heavy constant gamma 4	DEG_SCF_FBW7_1	133:140	ISRTPEVT	FBXW7	0.7507	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons