DegronMD

Uniprot ID: P01861

Source protein: Immunoglobulin heavy constant gamma 4

Source gene: IGHG4

Class: DEG_SCF_FBW7_1

Location: 133:140

E3 ligase: FBXW7

DEGRON score: 0.7507

ASA_SCORE: 61.2375

COIL: 0.5831

CONS_SCORE: 0.452

DSS_SCORE: 0.2728

HELIX: 0.0235

FCONS_SCORE: 1.1913

RIG_SCORE: 0.8246

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.V146M	TCGA-80-5611	LUAD	TCGA	ISRTPEVT	DEG_SCF_FBW7_1	0.1667
p.V146M	TCGA-OR-A5LB	ACC	TCGA	ISRTPEVT	DEG_SCF_FBW7_1	0.1667
p.V146M	DO23822	LUAD	ICGC	ISRTPEVT	DEG_SCF_FBW7_1	0.1667
p.Q148H	TCGA-AA-A02W	COAD	TCGA	ISRTPEVT	DEG_SCF_FBW7_1	0.1111
p.Q148H	DO7779	COAD	ICGC	ISRTPEVT	DEG_SCF_FBW7_1	0.1111
p.R135Q	TCGA-AG-3732	READ	TCGA	ISRTPEVT	DEG_SCF_FBW7_1	0.6218
p.R135Q	TCGA-CV-7430	HNSC	TCGA	ISRTPEVT	DEG_SCF_FBW7_1	0.6218
p.R135Q	DO15190	HNSC	ICGC	ISRTPEVT	DEG_SCF_FBW7_1	0.6218
p.R135Q	DO37114	READ	ICGC	ISRTPEVT	DEG_SCF_FBW7_1	0.6218
p.I133F	TCGA-DK-A1AC	BLCA	TCGA	ISRTPEVT	DEG_SCF_FBW7_1	0.7415
p.I133F	DO514	BLCA	ICGC	ISRTPEVT	DEG_SCF_FBW7_1	0.7415
p.M132I	TCGA-DK-A1AC	BLCA	TCGA	ISRTPEVT	DEG_SCF_FBW7_1	0.3056
p.M132I	TCGA-ER-A193	SKCM	TCGA	ISRTPEVT	DEG_SCF_FBW7_1	0.3056
p.M132I	DO514	BLCA	ICGC	ISRTPEVT	DEG_SCF_FBW7_1	0.3056
p.M132I	DO220875	MELA	ICGC	ISRTPEVT	DEG_SCF_FBW7_1	0.3056
p.M132I	DO47368	SKCM	ICGC	ISRTPEVT	DEG_SCF_FBW7_1	0.3056
p.P125T	TCGA-FS-A1ZR	SKCM	TCGA	ISRTPEVT	DEG_SCF_FBW7_1	0.1111
p.P125T	DO37651	SKCM	ICGC	ISRTPEVT	DEG_SCF_FBW7_1	0.1111
p.T140M	TCGA-IB-7654	PAAD	TCGA	ISRTPEVT	DEG_SCF_FBW7_1	0.7423
p.T140M	TCGA-XF-AAN7	BLCA	TCGA	ISRTPEVT	DEG_SCF_FBW7_1	0.7423
p.T140M	DO51946	BLCA	ICGC	ISRTPEVT	DEG_SCF_FBW7_1	0.7423
p.T140M	DO225314	BRCA	ICGC	ISRTPEVT	DEG_SCF_FBW7_1	0.7423
p.T140M	DO51695	PAAD	ICGC	ISRTPEVT	DEG_SCF_FBW7_1	0.7423
p.R135G	DO228465	MALY	ICGC	ISRTPEVT	DEG_SCF_FBW7_1	0.6457
p.P137S	DO222595	MELA	ICGC	ISRTPEVT	DEG_SCF_FBW7_1	0.6752
p.I133M	DO222880	MELA	ICGC	ISRTPEVT	DEG_SCF_FBW7_1	0.6507
p.V142M	DO32863	PACA	ICGC	ISRTPEVT	DEG_SCF_FBW7_1	0.2778
p.R135W	DO51105	PRAD	ICGC	ISRTPEVT	DEG_SCF_FBW7_1	0.7523
p.P127S	DO233550	PRAD	ICGC	ISRTPEVT	DEG_SCF_FBW7_1	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P01857	Immunoglobulin heavy constant gamma 1	DEG_SCF_FBW7_1	136:143	ISRTPEVT	FBXW7	0.9288	More...
P01859	Immunoglobulin heavy constant gamma 2	DEG_SCF_FBW7_1	132:139	ISRTPEVT	FBXW7	0.7165	More...
P01860	Immunoglobulin heavy constant gamma 3	DEG_SCF_FBW7_1	183:190	ISRTPEVT	FBXW7	0.8894	More...
P01861	Immunoglobulin heavy constant gamma 4	DEG_SCF_FBW7_1	133:140	ISRTPEVT	FBXW7	0.7507	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: ISRTPEVT

Degron related mutations and impact score

Drug responses associated with IGHG4 mutations

All proteins holding degron of ISRTPEVT