DegronMD

Uniprot ID: P01859

Source protein: Immunoglobulin heavy constant gamma 2

Source gene: IGHG2

Class: DEG_SCF_FBW7_1

Location: 132:139

E3 ligase: FBXW7

DEGRON score: 0.7165

ASA_SCORE: 65.3375

COIL: 0.6068

CONS_SCORE: 0.4939

DSS_SCORE: 0.2761

HELIX: 0.0172

FCONS_SCORE: 0.9184

RIG_SCORE: 0.8117

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P123S	TCGA-55-8302	LUAD	TCGA	ISRTPEVT	DEG_SCF_FBW7_1	0.0833
p.P123S	DO45312	LUAD	ICGC	ISRTPEVT	DEG_SCF_FBW7_1	0.0833
p.V141M	TCGA-90-7964	LUSC	TCGA	ISRTPEVT	DEG_SCF_FBW7_1	0.2778
p.V141M	TCGA-BR-7703	STAD	TCGA	ISRTPEVT	DEG_SCF_FBW7_1	0.2778
p.V141M	DO27046	LUSC	ICGC	ISRTPEVT	DEG_SCF_FBW7_1	0.2778
p.V141M	DO38232	STAD	ICGC	ISRTPEVT	DEG_SCF_FBW7_1	0.2778
p.V145M	TCGA-A6-3808	COAD	TCGA	ISRTPEVT	DEG_SCF_FBW7_1	0.1667
p.V145M	TCGA-DY-A1H8	READ	TCGA	ISRTPEVT	DEG_SCF_FBW7_1	0.1667
p.V145M	DO8408	COAD	ICGC	ISRTPEVT	DEG_SCF_FBW7_1	0.1667
p.V145M	DO37181	READ	ICGC	ISRTPEVT	DEG_SCF_FBW7_1	0.1667
p.R134Q	TCGA-AX-A2HC	UCEC	TCGA	ISRTPEVT	DEG_SCF_FBW7_1	0.6218
p.R134Q	DO41572	UCEC	ICGC	ISRTPEVT	DEG_SCF_FBW7_1	0.6218
p.H147Q	TCGA-CN-4730	HNSC	TCGA	ISRTPEVT	DEG_SCF_FBW7_1	0.1111
p.H147Q	DO14234	HNSC	ICGC	ISRTPEVT	DEG_SCF_FBW7_1	0.1111
p.T135N	TCGA-CU-A0YR	BLCA	TCGA	ISRTPEVT	DEG_SCF_FBW7_1	0.7055
p.T135N	DO449	BLCA	ICGC	ISRTPEVT	DEG_SCF_FBW7_1	0.7055
p.M131I	TCGA-D3-A8GM	SKCM	TCGA	ISRTPEVT	DEG_SCF_FBW7_1	0.3056
p.M131I	TCGA-DA-A1IC	SKCM	TCGA	ISRTPEVT	DEG_SCF_FBW7_1	0.3056
p.M131I	TCGA-WE-A8ZX	SKCM	TCGA	ISRTPEVT	DEG_SCF_FBW7_1	0.3056
p.M131I	TCGA-YG-AA3N	SKCM	TCGA	ISRTPEVT	DEG_SCF_FBW7_1	0.3056
p.M131I	DO222875	MELA	ICGC	ISRTPEVT	DEG_SCF_FBW7_1	0.3056
p.M131I	DO37430	SKCM	ICGC	ISRTPEVT	DEG_SCF_FBW7_1	0.3056
p.M131I	DO50288	SKCM	ICGC	ISRTPEVT	DEG_SCF_FBW7_1	0.3056
p.M131I	DO51298	SKCM	ICGC	ISRTPEVT	DEG_SCF_FBW7_1	0.3056
p.M131I	DO51291	SKCM	ICGC	ISRTPEVT	DEG_SCF_FBW7_1	0.3056
p.R134L	TCGA-EE-A2GN	SKCM	TCGA	ISRTPEVT	DEG_SCF_FBW7_1	0.7316
p.R134L	DO37896	SKCM	ICGC	ISRTPEVT	DEG_SCF_FBW7_1	0.7316
p.T129I	TCGA-FF-A7CQ	DLBC	TCGA	ISRTPEVT	DEG_SCF_FBW7_1	0.6944
p.T129I	DO219893	DLBC	ICGC	ISRTPEVT	DEG_SCF_FBW7_1	0.6944
p.T139M	TCGA-VQ-A8P2	STAD	TCGA	ISRTPEVT	DEG_SCF_FBW7_1	0.7423
p.T139M	DO51761	STAD	ICGC	ISRTPEVT	DEG_SCF_FBW7_1	0.7423
p.S146N	TCGA-YD-A9TA	SKCM	TCGA	ISRTPEVT	DEG_SCF_FBW7_1	0.1389
p.S146N	DO219503	SKCM	ICGC	ISRTPEVT	DEG_SCF_FBW7_1	0.1389
p.P126A	DO27104	LUSC	ICGC	ISRTPEVT	DEG_SCF_FBW7_1	0.1667
p.D128A	DO228414	MALY	ICGC	ISRTPEVT	DEG_SCF_FBW7_1	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P01857	Immunoglobulin heavy constant gamma 1	DEG_SCF_FBW7_1	136:143	ISRTPEVT	FBXW7	0.9288	More...
P01859	Immunoglobulin heavy constant gamma 2	DEG_SCF_FBW7_1	132:139	ISRTPEVT	FBXW7	0.7165	More...
P01860	Immunoglobulin heavy constant gamma 3	DEG_SCF_FBW7_1	183:190	ISRTPEVT	FBXW7	0.8894	More...
P01861	Immunoglobulin heavy constant gamma 4	DEG_SCF_FBW7_1	133:140	ISRTPEVT	FBXW7	0.7507	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: ISRTPEVT

Degron related mutations and impact score

Drug responses associated with IGHG2 mutations

All proteins holding degron of ISRTPEVT