DegronMD - P01877(IGHA2)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.A130V	TCGA-CJ-4904	KIRC	TCGA	HRPALEDLL	DEG_APCC_DBOX_1	117:125	Mutation rewiring degron network	0.1944
p.A130V	DO18213	KIRC	ICGC	HRPALEDLL	DEG_APCC_DBOX_1	117:125	Mutation rewiring degron network	0.1944
p.A130V	DO228605	MALY	ICGC	HRPALEDLL	DEG_APCC_DBOX_1	117:125	Mutation rewiring degron network	0.1944
p.A130V	DO232761	PBCA	ICGC	HRPALEDLL	DEG_APCC_DBOX_1	117:125	Mutation rewiring degron network	0.1944
p.G127R	TCGA-EK-A3GK	CESC	TCGA	HRPALEDLL	DEG_APCC_DBOX_1	117:125	Mutation rewiring degron network	0.2778
p.G127R	DO49964	CESC	ICGC	HRPALEDLL	DEG_APCC_DBOX_1	117:125	Mutation rewiring degron network	0.2778
p.G127D	TCGA-FF-8061	DLBC	TCGA	HRPALEDLL	DEG_APCC_DBOX_1	117:125	Mutation rewiring degron network	0.2778
p.G127D	DO222307	DLBC	ICGC	HRPALEDLL	DEG_APCC_DBOX_1	117:125	Mutation rewiring degron network	0.2778
p.S115P	TCGA-IB-7651	PAAD	TCGA	HRPALEDLL	DEG_APCC_DBOX_1	117:125	Mutation rewiring degron network	0.2778
p.S115P	DO46657	PAAD	ICGC	HRPALEDLL	DEG_APCC_DBOX_1	117:125	Mutation rewiring degron network	0.2778
p.E122Q	TCGA-MV-A51V	BLCA	TCGA	HRPALEDLL	DEG_APCC_DBOX_1	117:125	Mutation altering degron motif	0.5633
p.E122Q	DO474	BLCA	ICGC	HRPALEDLL	DEG_APCC_DBOX_1	117:125	Mutation altering degron motif	0.5633
p.L126S	TCGA-ZR-A9CJ	ESCA	TCGA	HRPALEDLL	DEG_APCC_DBOX_1	117:125	Mutation rewiring degron network	0.3056
p.E122K	DO220882	MELA	ICGC	HRPALEDLL	DEG_APCC_DBOX_1	117:125	Mutation altering degron motif	0.591
p.P112S	DO220906	MELA	ICGC	HRPALEDLL	DEG_APCC_DBOX_1	117:125	Mutation rewiring degron network	0.1944
p.D123N	DO222702	MELA	ICGC	HRPALEDLL	DEG_APCC_DBOX_1	117:125	Mutation altering degron motif	0.5821
p.L121F	DO222843	MELA	ICGC	HRPALEDLL	DEG_APCC_DBOX_1	117:125	Mutation altering degron motif	0.6981

Kaplan plot for IGHA2 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

IGHA2

UniProt ID: P01877

Entrez ID:

Protein name: Immunoglobulin heavy constant alpha 2 (Ig alpha-2 chain C region) (Ig alpha-2 chain C region BUT) (Ig alpha-2 chain C region LAN)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for IGHA2 in