DegronMD

Uniprot ID: P01877

Source protein: Immunoglobulin heavy constant alpha 2

Source gene: IGHA2

Class: DEG_APCC_DBOX_1

Location: 117:125

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.5782

ASA_SCORE: 67.4333

COIL: 0.529

CONS_SCORE: 0.522

DSS_SCORE: 0.2226

HELIX: 0.4451

FCONS_SCORE: 1.2081

RIG_SCORE: 0.8017

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A130V	TCGA-CJ-4904	KIRC	TCGA	HRPALEDLL	DEG_APCC_DBOX_1	0.1944
p.A130V	DO18213	KIRC	ICGC	HRPALEDLL	DEG_APCC_DBOX_1	0.1944
p.A130V	DO228605	MALY	ICGC	HRPALEDLL	DEG_APCC_DBOX_1	0.1944
p.A130V	DO232761	PBCA	ICGC	HRPALEDLL	DEG_APCC_DBOX_1	0.1944
p.G127R	TCGA-EK-A3GK	CESC	TCGA	HRPALEDLL	DEG_APCC_DBOX_1	0.2778
p.G127R	DO49964	CESC	ICGC	HRPALEDLL	DEG_APCC_DBOX_1	0.2778
p.G127D	TCGA-FF-8061	DLBC	TCGA	HRPALEDLL	DEG_APCC_DBOX_1	0.2778
p.G127D	DO222307	DLBC	ICGC	HRPALEDLL	DEG_APCC_DBOX_1	0.2778
p.S115P	TCGA-IB-7651	PAAD	TCGA	HRPALEDLL	DEG_APCC_DBOX_1	0.2778
p.S115P	DO46657	PAAD	ICGC	HRPALEDLL	DEG_APCC_DBOX_1	0.2778
p.E122Q	TCGA-MV-A51V	BLCA	TCGA	HRPALEDLL	DEG_APCC_DBOX_1	0.5633
p.E122Q	DO474	BLCA	ICGC	HRPALEDLL	DEG_APCC_DBOX_1	0.5633
p.L126S	TCGA-ZR-A9CJ	ESCA	TCGA	HRPALEDLL	DEG_APCC_DBOX_1	0.3056
p.E122K	DO220882	MELA	ICGC	HRPALEDLL	DEG_APCC_DBOX_1	0.591
p.P112S	DO220906	MELA	ICGC	HRPALEDLL	DEG_APCC_DBOX_1	0.1944
p.D123N	DO222702	MELA	ICGC	HRPALEDLL	DEG_APCC_DBOX_1	0.5821
p.L121F	DO222843	MELA	ICGC	HRPALEDLL	DEG_APCC_DBOX_1	0.6981

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P01876	Immunoglobulin heavy constant alpha 1	DEG_APCC_DBOX_1	130:138	HRPALEDLL	APC,CDC20,FZR1	0.9023	More...
P01877	Immunoglobulin heavy constant alpha 2	DEG_APCC_DBOX_1	117:125	HRPALEDLL	APC,CDC20,FZR1	0.5782	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons