DegronMD

Uniprot ID: P01876

Source protein: Immunoglobulin heavy constant alpha 1

Source gene: IGHA1

Class: DEG_APCC_DBOX_1

Location: 130:138

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9023

ASA_SCORE: 70.5444

COIL: 0.5257

CONS_SCORE: 0.5209

DSS_SCORE: 0.315

HELIX: 0.3907

FCONS_SCORE: 1.3266

RIG_SCORE: 0.7868

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P120H	TCGA-28-5214	GBM	TCGA	HRPALEDLL	DEG_APCC_DBOX_1	0.0556
p.P120H	DO14061	GBM	ICGC	HRPALEDLL	DEG_APCC_DBOX_1	0.0556
p.E135Q	TCGA-62-A46O	LUAD	TCGA	HRPALEDLL	DEG_APCC_DBOX_1	0.5633
p.E135Q	DO26240	LUAD	ICGC	HRPALEDLL	DEG_APCC_DBOX_1	0.5633
p.E135K	TCGA-C8-A130	BRCA	TCGA	HRPALEDLL	DEG_APCC_DBOX_1	0.591
p.E135K	DO3804	BRCA	ICGC	HRPALEDLL	DEG_APCC_DBOX_1	0.591
p.E135K	DO233223	GACA	ICGC	HRPALEDLL	DEG_APCC_DBOX_1	0.591
p.H130Q	TCGA-E9-A228	BRCA	TCGA	HRPALEDLL	DEG_APCC_DBOX_1	0.647
p.H130Q	DO1486	BRCA	ICGC	HRPALEDLL	DEG_APCC_DBOX_1	0.647
p.P120S	TCGA-EB-A6QY	SKCM	TCGA	HRPALEDLL	DEG_APCC_DBOX_1	0.0556
p.P120S	DO48702	SKCM	ICGC	HRPALEDLL	DEG_APCC_DBOX_1	0.0556
p.T146M	TCGA-EO-A22R	UCEC	TCGA	HRPALEDLL	DEG_APCC_DBOX_1	0.1111
p.T146M	DO42713	UCEC	ICGC	HRPALEDLL	DEG_APCC_DBOX_1	0.1111
p.T148I	TCGA-FF-A7CR	DLBC	TCGA	HRPALEDLL	DEG_APCC_DBOX_1	0.0556
p.T148I	DO219894	DLBC	ICGC	HRPALEDLL	DEG_APCC_DBOX_1	0.0556
p.L145I	TCGA-IB-7651	PAAD	TCGA	HRPALEDLL	DEG_APCC_DBOX_1	0.1389
p.L145I	DO46657	PAAD	ICGC	HRPALEDLL	DEG_APCC_DBOX_1	0.1389
p.N144K	TCGA-QM-A5NM	UCS	TCGA	HRPALEDLL	DEG_APCC_DBOX_1	0.1667
p.R126Q	TCGA-Z2-A8RT	SKCM	TCGA	HRPALEDLL	DEG_APCC_DBOX_1	0.2222
p.R126Q	DO51301	SKCM	ICGC	HRPALEDLL	DEG_APCC_DBOX_1	0.2222
p.P132L	DO231967	LICA	ICGC	HRPALEDLL	DEG_APCC_DBOX_1	0.6471
p.H130N	DO38775	STAD	ICGC	HRPALEDLL	DEG_APCC_DBOX_1	0.6312

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P01876	Immunoglobulin heavy constant alpha 1	DEG_APCC_DBOX_1	130:138	HRPALEDLL	APC,CDC20,FZR1	0.9023	More...
P01877	Immunoglobulin heavy constant alpha 2	DEG_APCC_DBOX_1	117:125	HRPALEDLL	APC,CDC20,FZR1	0.5782	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons