DegronMD - P01876(IGHA1)

GO - Biological processes (BP): View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

Choose a PDB ID:
Open in full screen with detailed sequence annotations

Data table is loading....

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.C101F	TCGA-22-4593	LUSC	TCGA	PPTPSPS	DEG_SCF_FBW7_1	107:113	Mutation rewiring degron network	0.1667
p.C101F	DO27018	LUSC	ICGC	PPTPSPS	DEG_SCF_FBW7_1	107:113	Mutation rewiring degron network	0.1667
p.P120H	TCGA-28-5214	GBM	TCGA	HRPALEDLL	DEG_APCC_DBOX_1	130:138	Mutation rewiring degron network	0.0556
p.P120H	TCGA-28-5214	GBM	TCGA	PPTPSPS	DEG_SCF_FBW7_1	107:113	Mutation rewiring degron network	0.1389
p.P120H	DO14061	GBM	ICGC	HRPALEDLL	DEG_APCC_DBOX_1	130:138	Mutation rewiring degron network	0.0556
p.P120H	DO14061	GBM	ICGC	PPTPSPS	DEG_SCF_FBW7_1	107:113	Mutation rewiring degron network	0.1389
p.P118R	TCGA-38-4632	LUAD	TCGA	PPTPSPS	DEG_SCF_FBW7_1	107:113	Mutation rewiring degron network	0.1944
p.P118R	DO23858	LUAD	ICGC	PPTPSPS	DEG_SCF_FBW7_1	107:113	Mutation rewiring degron network	0.1944
p.E135Q	TCGA-62-A46O	LUAD	TCGA	HRPALEDLL	DEG_APCC_DBOX_1	130:138	Mutation altering degron motif	0.5633
p.E135Q	DO26240	LUAD	ICGC	HRPALEDLL	DEG_APCC_DBOX_1	130:138	Mutation altering degron motif	0.5633
p.V99M	TCGA-BR-6852	STAD	TCGA	PPTPSPS	DEG_SCF_FBW7_1	107:113	Mutation rewiring degron network	0.1111
p.V99M	DO38202	STAD	ICGC	PPTPSPS	DEG_SCF_FBW7_1	107:113	Mutation rewiring degron network	0.1111
p.E135K	TCGA-C8-A130	BRCA	TCGA	HRPALEDLL	DEG_APCC_DBOX_1	130:138	Mutation altering degron motif	0.591
p.E135K	DO3804	BRCA	ICGC	HRPALEDLL	DEG_APCC_DBOX_1	130:138	Mutation altering degron motif	0.591
p.E135K	DO233223	GACA	ICGC	HRPALEDLL	DEG_APCC_DBOX_1	130:138	Mutation altering degron motif	0.591
p.H130Q	TCGA-E9-A228	BRCA	TCGA	HRPALEDLL	DEG_APCC_DBOX_1	130:138	Mutation altering degron motif	0.647
p.H130Q	DO1486	BRCA	ICGC	HRPALEDLL	DEG_APCC_DBOX_1	130:138	Mutation altering degron motif	0.647
p.P112L	TCGA-EB-A5FP	SKCM	TCGA	PPTPSPS	DEG_SCF_FBW7_1	107:113	Mutation altering degron motif	0.6471
p.P112L	DO47362	SKCM	ICGC	PPTPSPS	DEG_SCF_FBW7_1	107:113	Mutation altering degron motif	0.6471
p.P120S	TCGA-EB-A6QY	SKCM	TCGA	HRPALEDLL	DEG_APCC_DBOX_1	130:138	Mutation rewiring degron network	0.0556
p.P120S	TCGA-EB-A6QY	SKCM	TCGA	PPTPSPS	DEG_SCF_FBW7_1	107:113	Mutation rewiring degron network	0.1389
p.P120S	DO48702	SKCM	ICGC	HRPALEDLL	DEG_APCC_DBOX_1	130:138	Mutation rewiring degron network	0.0556
p.P120S	DO48702	SKCM	ICGC	PPTPSPS	DEG_SCF_FBW7_1	107:113	Mutation rewiring degron network	0.1389
p.T146M	TCGA-EO-A22R	UCEC	TCGA	HRPALEDLL	DEG_APCC_DBOX_1	130:138	Mutation rewiring degron network	0.1111
p.T146M	DO42713	UCEC	ICGC	HRPALEDLL	DEG_APCC_DBOX_1	130:138	Mutation rewiring degron network	0.1111
p.T148I	TCGA-FF-A7CR	DLBC	TCGA	HRPALEDLL	DEG_APCC_DBOX_1	130:138	Mutation rewiring degron network	0.0556
p.T148I	DO219894	DLBC	ICGC	HRPALEDLL	DEG_APCC_DBOX_1	130:138	Mutation rewiring degron network	0.0556
p.L145I	TCGA-IB-7651	PAAD	TCGA	HRPALEDLL	DEG_APCC_DBOX_1	130:138	Mutation rewiring degron network	0.1389
p.L145I	DO46657	PAAD	ICGC	HRPALEDLL	DEG_APCC_DBOX_1	130:138	Mutation rewiring degron network	0.1389
p.N144K	TCGA-QM-A5NM	UCS	TCGA	HRPALEDLL	DEG_APCC_DBOX_1	130:138	Mutation rewiring degron network	0.1667
p.R126Q	TCGA-Z2-A8RT	SKCM	TCGA	HRPALEDLL	DEG_APCC_DBOX_1	130:138	Mutation rewiring degron network	0.2222
p.R126Q	DO51301	SKCM	ICGC	HRPALEDLL	DEG_APCC_DBOX_1	130:138	Mutation rewiring degron network	0.2222
p.P132L	DO231967	LICA	ICGC	HRPALEDLL	DEG_APCC_DBOX_1	130:138	Mutation altering degron motif	0.6471
p.P104L	DO222494	MELA	ICGC	PPTPSPS	DEG_SCF_FBW7_1	107:113	Mutation rewiring degron network	0.25
p.P112S	DO222557	MELA	ICGC	PPTPSPS	DEG_SCF_FBW7_1	107:113	Mutation altering degron motif	0.5641
p.P110A	DO29146	OV	ICGC	PPTPSPS	DEG_SCF_FBW7_1	107:113	Mutation altering degron motif	0.7503
p.T98N	DO232224	PBCA	ICGC	PPTPSPS	DEG_SCF_FBW7_1	107:113	Mutation rewiring degron network	0.0833
p.H130N	DO38775	STAD	ICGC	HRPALEDLL	DEG_APCC_DBOX_1	130:138	Mutation altering degron motif	0.6312

Kaplan plot for IGHA1 in

Select cancer type:
Download patient class data (Lower:Upper = 50%:50%)

*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

IGHA1

UniProt ID: P01876

Entrez ID:

Protein name: Immunoglobulin heavy constant alpha 1 (Ig alpha-1 chain C region) (Ig alpha-1 chain C region BUR) (Ig alpha-1 chain C region TRO)

External links: UniprotKB HGNC RefSeq COSMIC

Data table is loading....

Kaplan plot for IGHA1 in