DegronMD

Uniprot ID: P01876

Source protein: Immunoglobulin heavy constant alpha 1

Source gene: IGHA1

Class: DEG_SCF_FBW7_1

Location: 107:113

E3 ligase: FBXW7

DEGRON score: 0.926

ASA_SCORE: 78.9857

COIL: 0.9539

CONS_SCORE: 0.2505

DSS_SCORE: 0.5875

HELIX: 0.0146

FCONS_SCORE: 0.8191

RIG_SCORE: 0.4799

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.C101F	TCGA-22-4593	LUSC	TCGA	PPTPSPS	DEG_SCF_FBW7_1	0.1667
p.C101F	DO27018	LUSC	ICGC	PPTPSPS	DEG_SCF_FBW7_1	0.1667
p.P120H	TCGA-28-5214	GBM	TCGA	PPTPSPS	DEG_SCF_FBW7_1	0.1389
p.P120H	DO14061	GBM	ICGC	PPTPSPS	DEG_SCF_FBW7_1	0.1389
p.P118R	TCGA-38-4632	LUAD	TCGA	PPTPSPS	DEG_SCF_FBW7_1	0.1944
p.P118R	DO23858	LUAD	ICGC	PPTPSPS	DEG_SCF_FBW7_1	0.1944
p.V99M	TCGA-BR-6852	STAD	TCGA	PPTPSPS	DEG_SCF_FBW7_1	0.1111
p.V99M	DO38202	STAD	ICGC	PPTPSPS	DEG_SCF_FBW7_1	0.1111
p.P112L	TCGA-EB-A5FP	SKCM	TCGA	PPTPSPS	DEG_SCF_FBW7_1	0.6471
p.P112L	DO47362	SKCM	ICGC	PPTPSPS	DEG_SCF_FBW7_1	0.6471
p.P120S	TCGA-EB-A6QY	SKCM	TCGA	PPTPSPS	DEG_SCF_FBW7_1	0.1389
p.P120S	DO48702	SKCM	ICGC	PPTPSPS	DEG_SCF_FBW7_1	0.1389
p.P104L	DO222494	MELA	ICGC	PPTPSPS	DEG_SCF_FBW7_1	0.25
p.P112S	DO222557	MELA	ICGC	PPTPSPS	DEG_SCF_FBW7_1	0.5641
p.P110A	DO29146	OV	ICGC	PPTPSPS	DEG_SCF_FBW7_1	0.7503
p.T98N	DO232224	PBCA	ICGC	PPTPSPS	DEG_SCF_FBW7_1	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P01876	Immunoglobulin heavy constant alpha 1	DEG_SCF_FBW7_1	107:113	PPTPSPS	FBXW7	0.926	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons