DegronMD - P02545(LMNA)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R89S	TCGA-B5-A11H	UCEC	TCGA	ARKTLDSVA	DEG_APCC_DBOX_1	88:96	Mutation altering degron motif	0.7427
p.R89S	DO42825	UCEC	ICGC	ARKTLDSVA	DEG_APCC_DBOX_1	88:96	Mutation altering degron motif	0.7427
p.E84K	TCGA-GM-A2D9	BRCA	TCGA	ARKTLDSVA	DEG_APCC_DBOX_1	88:96	Mutation rewiring degron network	0.2222
p.E84K	DO4810	BRCA	ICGC	ARKTLDSVA	DEG_APCC_DBOX_1	88:96	Mutation rewiring degron network	0.2222
p.K78N	TCGA-VQ-A91D	STAD	TCGA	ARKTLDSVA	DEG_APCC_DBOX_1	88:96	Mutation blocking ubiquitination signal	0.5
p.K78N	DO51783	STAD	ICGC	ARKTLDSVA	DEG_APCC_DBOX_1	88:96	Mutation blocking ubiquitination signal	0.5
p.R91Q	DO2072	BRCA	ICGC	ARKTLDSVA	DEG_APCC_DBOX_1	88:96	Mutation altering degron motif	0.7329
p.R90W	DO230326	COCA	ICGC	ARKTLDSVA	DEG_APCC_DBOX_1	88:96	Mutation altering degron motif	0.8634
p.R90W	SNU-1040	large intestine	COSMIC	ARKTLDSVA	DEG_APCC_DBOX_1	88:96	Mutation altering degron motif	0.8634
p.E79D	DO229019	LICA	ICGC	ARKTLDSVA	DEG_APCC_DBOX_1	88:96	Mutation rewiring degron network	0.0833
p.E87D	DO229019	LICA	ICGC	ARKTLDSVA	DEG_APCC_DBOX_1	88:96	Mutation rewiring degron network	0.3056
p.E98K	DO229453	SKCA	ICGC	ARKTLDSVA	DEG_APCC_DBOX_1	88:96	Mutation rewiring degron network	0.2778
p.L98M	DO229227	THCA	ICGC	ARKTLDSVA	DEG_APCC_DBOX_1	88:96	Mutation rewiring degron network	0.2778
p.E82V	SIDM00719	Small Cell Lung Carcinoma	GDSC	ARKTLDSVA	DEG_APCC_DBOX_1	88:96	Mutation rewiring degron network	0.1667
p.E82V	NCI-H345	lung	COSMIC	ARKTLDSVA	DEG_APCC_DBOX_1	88:96	Mutation rewiring degron network	0.1667
p.K97T	ACH-001736	Leukemia	CCLE	ARKTLDSVA	DEG_APCC_DBOX_1	88:96	Mutation blocking ubiquitination signal	0.75
p.G78C	P30-OHK	haematopoietic and lymphoid tissue	COSMIC	ARKTLDSVA	DEG_APCC_DBOX_1	88:96	Mutation blocking ubiquitination signal	0.5
p.G96C	P30-OHK	haematopoietic and lymphoid tissue	COSMIC	ARKTLDSVA	DEG_APCC_DBOX_1	88:96	Mutation altering degron motif	0.76
p.R85W	Jurkat	haematopoietic and lymphoid tissue	COSMIC	ARKTLDSVA	DEG_APCC_DBOX_1	88:96	Mutation rewiring degron network	0.25

Kaplan plot for LMNA in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

LMNA

UniProt ID: P02545

Entrez ID: 4000

Protein name: Prelamin-A/C [Cleaved into: Lamin-A/C (70 kDa lamin) (Renal carcinoma antigen NY-REN-32)]

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for LMNA in