DegronMD

Uniprot ID: P02545

Source protein: Prelamin-A/C [Cleaved into: Lamin-A/C

Source gene: LMNA

Class: DEG_APCC_DBOX_1

Location: 88:96

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.5466

ASA_SCORE: 51.1

COIL: 0.0167

CONS_SCORE: 0.9052

DSS_SCORE: 0.318

HELIX: 0.9837

FCONS_SCORE: 1.0224

RIG_SCORE: 0.7874

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R89S	TCGA-B5-A11H	UCEC	TCGA	ARKTLDSVA	DEG_APCC_DBOX_1	0.7427
p.R89S	DO42825	UCEC	ICGC	ARKTLDSVA	DEG_APCC_DBOX_1	0.7427
p.E84K	TCGA-GM-A2D9	BRCA	TCGA	ARKTLDSVA	DEG_APCC_DBOX_1	0.2222
p.E84K	DO4810	BRCA	ICGC	ARKTLDSVA	DEG_APCC_DBOX_1	0.2222
p.K78N	TCGA-VQ-A91D	STAD	TCGA	ARKTLDSVA	DEG_APCC_DBOX_1	0.5
p.K78N	DO51783	STAD	ICGC	ARKTLDSVA	DEG_APCC_DBOX_1	0.5
p.R91Q	DO2072	BRCA	ICGC	ARKTLDSVA	DEG_APCC_DBOX_1	0.7329
p.R90W	DO230326	COCA	ICGC	ARKTLDSVA	DEG_APCC_DBOX_1	0.8634
p.R90W	SNU-1040	large_intestine	COSMIC	ARKTLDSVA	DEG_APCC_DBOX_1	0.8634
p.E79D	DO229019	LICA	ICGC	ARKTLDSVA	DEG_APCC_DBOX_1	0.0833
p.E87D	DO229019	LICA	ICGC	ARKTLDSVA	DEG_APCC_DBOX_1	0.3056
p.E98K	DO229453	SKCA	ICGC	ARKTLDSVA	DEG_APCC_DBOX_1	0.2778
p.L98M	DO229227	THCA	ICGC	ARKTLDSVA	DEG_APCC_DBOX_1	0.2778
p.E82V	SIDM00719	Small Cell Lung Carcinoma	GDSC	ARKTLDSVA	DEG_APCC_DBOX_1	0.1667
p.E82V	NCI-H345	lung	COSMIC	ARKTLDSVA	DEG_APCC_DBOX_1	0.1667
p.K97T	ACH-001736	Leukemia	CCLE	ARKTLDSVA	DEG_APCC_DBOX_1	0.75
p.G78C	P30-OHK	haematopoietic_and_lymphoid_tissue	COSMIC	ARKTLDSVA	DEG_APCC_DBOX_1	0.5
p.G96C	P30-OHK	haematopoietic_and_lymphoid_tissue	COSMIC	ARKTLDSVA	DEG_APCC_DBOX_1	0.76
p.R85W	Jurkat	haematopoietic_and_lymphoid_tissue	COSMIC	ARKTLDSVA	DEG_APCC_DBOX_1	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P02545	Prelamin-A/C [Cleaved into: Lamin-A/C	DEG_APCC_DBOX_1	88:96	ARKTLDSVA	APC,CDC20,FZR1	0.5466	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons