DegronMD - P02549(SPTA1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.Q1371L	TCGA-4Z-AA7R	BLCA	TCGA	DSGHHAS	DEG_SCF_TRCP1_1	1357:1363	Mutation rewiring degron network	0.1111
p.Q1371L	DO51866	BLCA	ICGC	DSGHHAS	DEG_SCF_TRCP1_1	1357:1363	Mutation rewiring degron network	0.1111
p.G1359V	TCGA-64-5775	LUAD	TCGA	DSGHHAS	DEG_SCF_TRCP1_1	1357:1363	Mutation altering degron motif	0.7532
p.G1359V	DO26025	LUAD	ICGC	DSGHHAS	DEG_SCF_TRCP1_1	1357:1363	Mutation altering degron motif	0.7532
p.A1372V	TCGA-B5-A0JY	UCEC	TCGA	DSGHHAS	DEG_SCF_TRCP1_1	1357:1363	Mutation rewiring degron network	0.0833
p.A1372V	DO43041	UCEC	ICGC	DSGHHAS	DEG_SCF_TRCP1_1	1357:1363	Mutation rewiring degron network	0.0833
p.E1354K	TCGA-B5-A11R	UCEC	TCGA	DSGHHAS	DEG_SCF_TRCP1_1	1357:1363	Mutation rewiring degron network	0.25
p.E1354K	DO43787	UCEC	ICGC	DSGHHAS	DEG_SCF_TRCP1_1	1357:1363	Mutation rewiring degron network	0.25
p.P1364H	TCGA-BF-A1Q0	SKCM	TCGA	DSGHHAS	DEG_SCF_TRCP1_1	1357:1363	Mutation rewiring degron network	0.3056
p.P1364H	DO47374	SKCM	ICGC	DSGHHAS	DEG_SCF_TRCP1_1	1357:1363	Mutation rewiring degron network	0.3056
p.H1360Y	TCGA-BR-4257	STAD	TCGA	DSGHHAS	DEG_SCF_TRCP1_1	1357:1363	Mutation altering degron motif	0.6118
p.H1360Y	DO222698	ESCA	ICGC	DSGHHAS	DEG_SCF_TRCP1_1	1357:1363	Mutation altering degron motif	0.6118
p.H1360Y	DO38683	STAD	ICGC	DSGHHAS	DEG_SCF_TRCP1_1	1357:1363	Mutation altering degron motif	0.6118
p.A1347T	TCGA-CK-4948	COAD	TCGA	DSGHHAS	DEG_SCF_TRCP1_1	1357:1363	Mutation rewiring degron network	0.0556
p.A1347T	TCGA-E8-A414	THCA	TCGA	DSGHHAS	DEG_SCF_TRCP1_1	1357:1363	Mutation rewiring degron network	0.0556
p.A1347T	DO10598	COAD	ICGC	DSGHHAS	DEG_SCF_TRCP1_1	1357:1363	Mutation rewiring degron network	0.0556
p.A1347T	DO40450	THCA	ICGC	DSGHHAS	DEG_SCF_TRCP1_1	1357:1363	Mutation rewiring degron network	0.0556
p.E1367K	TCGA-D3-A5GO	SKCM	TCGA	DSGHHAS	DEG_SCF_TRCP1_1	1357:1363	Mutation rewiring degron network	0.2222
p.E1367K	TCGA-ER-A19F	SKCM	TCGA	DSGHHAS	DEG_SCF_TRCP1_1	1357:1363	Mutation rewiring degron network	0.2222
p.E1367K	DO37679	SKCM	ICGC	DSGHHAS	DEG_SCF_TRCP1_1	1357:1363	Mutation rewiring degron network	0.2222
p.E1367K	DO47419	SKCM	ICGC	DSGHHAS	DEG_SCF_TRCP1_1	1357:1363	Mutation rewiring degron network	0.2222
p.E1367K	SIDM01175	Other Sarcomas	GDSC	DSGHHAS	DEG_SCF_TRCP1_1	1357:1363	Mutation rewiring degron network	0.2222
p.E1367K	ACH-002309	Sarcoma	CCLE	DSGHHAS	DEG_SCF_TRCP1_1	1357:1363	Mutation rewiring degron network	0.2222
p.E1367K	SW684	soft tissue	COSMIC	DSGHHAS	DEG_SCF_TRCP1_1	1357:1363	Mutation rewiring degron network	0.2222
p.D1357N	TCGA-EB-A41A	SKCM	TCGA	DSGHHAS	DEG_SCF_TRCP1_1	1357:1363	Mutation altering degron motif	0.6932
p.D1357N	TCGA-FI-A2D0	UCEC	TCGA	DSGHHAS	DEG_SCF_TRCP1_1	1357:1363	Mutation altering degron motif	0.6932
p.D1357N	DO51053	PRAD	ICGC	DSGHHAS	DEG_SCF_TRCP1_1	1357:1363	Mutation altering degron motif	0.6932
p.D1357N	DO229456	SKCA	ICGC	DSGHHAS	DEG_SCF_TRCP1_1	1357:1363	Mutation altering degron motif	0.6932
p.D1357N	DO37429	SKCM	ICGC	DSGHHAS	DEG_SCF_TRCP1_1	1357:1363	Mutation altering degron motif	0.6932
p.D1357N	DO43891	UCEC	ICGC	DSGHHAS	DEG_SCF_TRCP1_1	1357:1363	Mutation altering degron motif	0.6932
p.D1350H	TCGA-TM-A7CA	LGG	TCGA	DSGHHAS	DEG_SCF_TRCP1_1	1357:1363	Mutation rewiring degron network	0.1389
p.D1350H	DO50227	LGG	ICGC	DSGHHAS	DEG_SCF_TRCP1_1	1357:1363	Mutation rewiring degron network	0.1389
p.S1352I	TCGA-UF-A7JF	HNSC	TCGA	DSGHHAS	DEG_SCF_TRCP1_1	1357:1363	Mutation rewiring degron network	0.1944
p.S1352I	DO222723	COCA	ICGC	DSGHHAS	DEG_SCF_TRCP1_1	1357:1363	Mutation rewiring degron network	0.1944
p.S1352I	DO52116	HNSC	ICGC	DSGHHAS	DEG_SCF_TRCP1_1	1357:1363	Mutation rewiring degron network	0.1944
p.I1356M	TCGA-VS-A959	CESC	TCGA	DSGHHAS	DEG_SCF_TRCP1_1	1357:1363	Mutation rewiring degron network	0.3056
p.I1356M	DO51640	CESC	ICGC	DSGHHAS	DEG_SCF_TRCP1_1	1357:1363	Mutation rewiring degron network	0.3056
p.L1355I	DO228081	EOPC	ICGC	DSGHHAS	DEG_SCF_TRCP1_1	1357:1363	Mutation rewiring degron network	0.2778
p.Q1371H	DO234393	ESAD	ICGC	DSGHHAS	DEG_SCF_TRCP1_1	1357:1363	Mutation rewiring degron network	0.1111
p.E1349Q	DO228756	GACA	ICGC	DSGHHAS	DEG_SCF_TRCP1_1	1357:1363	Mutation rewiring degron network	0.1111
p.E1365K	DO228856	LICA	ICGC	DSGHHAS	DEG_SCF_TRCP1_1	1357:1363	Mutation rewiring degron network	0.2778

Kaplan plot for SPTA1 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

SPTA1

UniProt ID: P02549

Entrez ID: 6708

Protein name: Spectrin alpha chain, erythrocytic 1 (Erythroid alpha-spectrin)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for SPTA1 in