DegronMD

Uniprot ID: P02549

Source protein: Spectrin alpha chain, erythrocytic 1

Source gene: SPTA1

Class: DEG_SCF_TRCP1_1

Location: 1357:1363

E3 ligase: BTRC

DEGRON score: 0.9489

ASA_SCORE: 79.2

COIL: 0.7833

CONS_SCORE: 0.5263

DSS_SCORE: 0.4653

HELIX: 0.215

FCONS_SCORE: 1.0766

RIG_SCORE: 0.643

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.Q1371L	TCGA-4Z-AA7R	BLCA	TCGA	DSGHHAS	DEG_SCF_TRCP1_1	0.1111
p.Q1371L	DO51866	BLCA	ICGC	DSGHHAS	DEG_SCF_TRCP1_1	0.1111
p.G1359V	TCGA-64-5775	LUAD	TCGA	DSGHHAS	DEG_SCF_TRCP1_1	0.7532
p.G1359V	DO26025	LUAD	ICGC	DSGHHAS	DEG_SCF_TRCP1_1	0.7532
p.A1372V	TCGA-B5-A0JY	UCEC	TCGA	DSGHHAS	DEG_SCF_TRCP1_1	0.0833
p.A1372V	DO43041	UCEC	ICGC	DSGHHAS	DEG_SCF_TRCP1_1	0.0833
p.E1354K	TCGA-B5-A11R	UCEC	TCGA	DSGHHAS	DEG_SCF_TRCP1_1	0.25
p.E1354K	DO43787	UCEC	ICGC	DSGHHAS	DEG_SCF_TRCP1_1	0.25
p.P1364H	TCGA-BF-A1Q0	SKCM	TCGA	DSGHHAS	DEG_SCF_TRCP1_1	0.3056
p.P1364H	DO47374	SKCM	ICGC	DSGHHAS	DEG_SCF_TRCP1_1	0.3056
p.H1360Y	TCGA-BR-4257	STAD	TCGA	DSGHHAS	DEG_SCF_TRCP1_1	0.6118
p.H1360Y	DO222698	ESCA	ICGC	DSGHHAS	DEG_SCF_TRCP1_1	0.6118
p.H1360Y	DO38683	STAD	ICGC	DSGHHAS	DEG_SCF_TRCP1_1	0.6118
p.A1347T	TCGA-CK-4948	COAD	TCGA	DSGHHAS	DEG_SCF_TRCP1_1	0.0556
p.A1347T	TCGA-E8-A414	THCA	TCGA	DSGHHAS	DEG_SCF_TRCP1_1	0.0556
p.A1347T	DO10598	COAD	ICGC	DSGHHAS	DEG_SCF_TRCP1_1	0.0556
p.A1347T	DO40450	THCA	ICGC	DSGHHAS	DEG_SCF_TRCP1_1	0.0556
p.E1367K	TCGA-D3-A5GO	SKCM	TCGA	DSGHHAS	DEG_SCF_TRCP1_1	0.2222
p.E1367K	TCGA-ER-A19F	SKCM	TCGA	DSGHHAS	DEG_SCF_TRCP1_1	0.2222
p.E1367K	DO37679	SKCM	ICGC	DSGHHAS	DEG_SCF_TRCP1_1	0.2222
p.E1367K	DO47419	SKCM	ICGC	DSGHHAS	DEG_SCF_TRCP1_1	0.2222
p.E1367K	SIDM01175	Other Sarcomas	GDSC	DSGHHAS	DEG_SCF_TRCP1_1	0.2222
p.E1367K	ACH-002309	Sarcoma	CCLE	DSGHHAS	DEG_SCF_TRCP1_1	0.2222
p.E1367K	SW684	soft_tissue	COSMIC	DSGHHAS	DEG_SCF_TRCP1_1	0.2222
p.D1357N	TCGA-EB-A41A	SKCM	TCGA	DSGHHAS	DEG_SCF_TRCP1_1	0.6932
p.D1357N	TCGA-FI-A2D0	UCEC	TCGA	DSGHHAS	DEG_SCF_TRCP1_1	0.6932
p.D1357N	DO51053	PRAD	ICGC	DSGHHAS	DEG_SCF_TRCP1_1	0.6932
p.D1357N	DO229456	SKCA	ICGC	DSGHHAS	DEG_SCF_TRCP1_1	0.6932
p.D1357N	DO37429	SKCM	ICGC	DSGHHAS	DEG_SCF_TRCP1_1	0.6932
p.D1357N	DO43891	UCEC	ICGC	DSGHHAS	DEG_SCF_TRCP1_1	0.6932
p.D1350H	TCGA-TM-A7CA	LGG	TCGA	DSGHHAS	DEG_SCF_TRCP1_1	0.1389
p.D1350H	DO50227	LGG	ICGC	DSGHHAS	DEG_SCF_TRCP1_1	0.1389
p.S1352I	TCGA-UF-A7JF	HNSC	TCGA	DSGHHAS	DEG_SCF_TRCP1_1	0.1944
p.S1352I	DO222723	COCA	ICGC	DSGHHAS	DEG_SCF_TRCP1_1	0.1944
p.S1352I	DO52116	HNSC	ICGC	DSGHHAS	DEG_SCF_TRCP1_1	0.1944
p.I1356M	TCGA-VS-A959	CESC	TCGA	DSGHHAS	DEG_SCF_TRCP1_1	0.3056
p.I1356M	DO51640	CESC	ICGC	DSGHHAS	DEG_SCF_TRCP1_1	0.3056
p.L1355I	DO228081	EOPC	ICGC	DSGHHAS	DEG_SCF_TRCP1_1	0.2778
p.Q1371H	DO234393	ESAD	ICGC	DSGHHAS	DEG_SCF_TRCP1_1	0.1111
p.E1349Q	DO228756	GACA	ICGC	DSGHHAS	DEG_SCF_TRCP1_1	0.1111
p.E1365K	DO228856	LICA	ICGC	DSGHHAS	DEG_SCF_TRCP1_1	0.2778

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: DSGHHAS

Degron related mutations and impact score

Drug responses associated with SPTA1 mutations

All proteins holding degron of DSGHHAS

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P02549	Spectrin alpha chain, erythrocytic 1	DEG_SCF_TRCP1_1	1357:1363	DSGHHAS	BTRC	0.9489	More...