DegronMD - P02585(TNNC2)

GO - Biological processes (BP): View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

Choose a PDB ID:
Open in full screen with detailed sequence annotations

Data table is loading....

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.V37I	TCGA-AX-A2HJ	UCEC	TCGA	LGQTPTKE	DEG_SCF_FBW7_2	47:54	Mutation rewiring degron network	0.0556
p.V37I	DO232761	PBCA	ICGC	LGQTPTKE	DEG_SCF_FBW7_2	47:54	Mutation rewiring degron network	0.0556
p.V37I	DO42105	UCEC	ICGC	LGQTPTKE	DEG_SCF_FBW7_2	47:54	Mutation rewiring degron network	0.0556
p.L40F	TCGA-D3-A2JC	SKCM	TCGA	LGQTPTKE	DEG_SCF_FBW7_2	47:54	Mutation rewiring degron network	0.1389
p.L40F	DO47578	SKCM	ICGC	LGQTPTKE	DEG_SCF_FBW7_2	47:54	Mutation rewiring degron network	0.1389
p.A58T	TCGA-EE-A29T	SKCM	TCGA	LGQTPTKE	DEG_SCF_FBW7_2	47:54	Mutation rewiring degron network	0.2222
p.A58T	DO37742	SKCM	ICGC	LGQTPTKE	DEG_SCF_FBW7_2	47:54	Mutation rewiring degron network	0.2222
p.R45T	TCGA-EE-A2GB	SKCM	TCGA	LGQTPTKE	DEG_SCF_FBW7_2	47:54	Mutation rewiring degron network	0.2778
p.R45T	DO222683	MELA	ICGC	LGQTPTKE	DEG_SCF_FBW7_2	47:54	Mutation rewiring degron network	0.2778
p.R45T	DO37417	SKCM	ICGC	LGQTPTKE	DEG_SCF_FBW7_2	47:54	Mutation rewiring degron network	0.2778
p.E54K	TCGA-FR-A726	SKCM	TCGA	LGQTPTKE	DEG_SCF_FBW7_2	47:54	Mutation altering degron motif	0.7022
p.E54K	DO48665	SKCM	ICGC	LGQTPTKE	DEG_SCF_FBW7_2	47:54	Mutation altering degron motif	0.7022
p.T42M	DO225175	BRCA	ICGC	LGQTPTKE	DEG_SCF_FBW7_2	47:54	Mutation blocking phosphorylation signal	0.6389
p.D57E	DO229025	LICA	ICGC	LGQTPTKE	DEG_SCF_FBW7_2	47:54	Mutation rewiring degron network	0.25
p.M46T	SIDM00337	Melanoma	GDSC	LGQTPTKE	DEG_SCF_FBW7_2	47:54	Mutation rewiring degron network	0.3056
p.M46T	ACH-000450	Skin Cancer	CCLE	LGQTPTKE	DEG_SCF_FBW7_2	47:54	Mutation rewiring degron network	0.3056
p.M46T	MEL-HO	skin	COSMIC	LGQTPTKE	DEG_SCF_FBW7_2	47:54	Mutation rewiring degron network	0.3056
p.G54V	OVISE	ovary	COSMIC	LGQTPTKE	DEG_SCF_FBW7_2	47:54	Mutation altering degron motif	0.7532

Kaplan plot for TNNC2 in

Select cancer type:
Download patient class data (Lower:Upper = 50%:50%)

*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

TNNC2

UniProt ID: P02585

Entrez ID: 7125

Protein name: Troponin C, skeletal muscle

External links: UniprotKB HGNC RefSeq COSMIC

Data table is loading....

Kaplan plot for TNNC2 in