DegronMD

Uniprot ID: P02585

Source protein: Troponin C, skeletal muscle

Source gene: TNNC2

Class: DEG_SCF_FBW7_2

Location: 47:54

E3 ligase: FBXW7

DEGRON score: 0.8884

ASA_SCORE: 75.6375

COIL: 0.7181

CONS_SCORE: 0.7253

DSS_SCORE: 0.3998

HELIX: 0.2648

FCONS_SCORE: 0.9463

RIG_SCORE: 0.7607

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.V37I	TCGA-AX-A2HJ	UCEC	TCGA	LGQTPTKE	DEG_SCF_FBW7_2	0.0556
p.V37I	DO232761	PBCA	ICGC	LGQTPTKE	DEG_SCF_FBW7_2	0.0556
p.V37I	DO42105	UCEC	ICGC	LGQTPTKE	DEG_SCF_FBW7_2	0.0556
p.L40F	TCGA-D3-A2JC	SKCM	TCGA	LGQTPTKE	DEG_SCF_FBW7_2	0.1389
p.L40F	DO47578	SKCM	ICGC	LGQTPTKE	DEG_SCF_FBW7_2	0.1389
p.A58T	TCGA-EE-A29T	SKCM	TCGA	LGQTPTKE	DEG_SCF_FBW7_2	0.2222
p.A58T	DO37742	SKCM	ICGC	LGQTPTKE	DEG_SCF_FBW7_2	0.2222
p.R45T	TCGA-EE-A2GB	SKCM	TCGA	LGQTPTKE	DEG_SCF_FBW7_2	0.2778
p.R45T	DO222683	MELA	ICGC	LGQTPTKE	DEG_SCF_FBW7_2	0.2778
p.R45T	DO37417	SKCM	ICGC	LGQTPTKE	DEG_SCF_FBW7_2	0.2778
p.E54K	TCGA-FR-A726	SKCM	TCGA	LGQTPTKE	DEG_SCF_FBW7_2	0.7022
p.E54K	DO48665	SKCM	ICGC	LGQTPTKE	DEG_SCF_FBW7_2	0.7022
p.T42M	DO225175	BRCA	ICGC	LGQTPTKE	DEG_SCF_FBW7_2	0.6389
p.D57E	DO229025	LICA	ICGC	LGQTPTKE	DEG_SCF_FBW7_2	0.25
p.M46T	SIDM00337	Melanoma	GDSC	LGQTPTKE	DEG_SCF_FBW7_2	0.3056
p.M46T	ACH-000450	Skin Cancer	CCLE	LGQTPTKE	DEG_SCF_FBW7_2	0.3056
p.M46T	MEL-HO	skin	COSMIC	LGQTPTKE	DEG_SCF_FBW7_2	0.3056
p.G54V	OVISE	ovary	COSMIC	LGQTPTKE	DEG_SCF_FBW7_2	0.7532

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P02585	Troponin C, skeletal muscle	DEG_SCF_FBW7_2	47:54	LGQTPTKE	FBXW7	0.8884	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons