DegronMD - P02647(APOA1)

GO - Biological processes (BP): adrenal gland development [GO:0030325]; blood vessel endothelial cell migration [GO:0043534]; cholesterol biosynthetic process [GO:0006695]; cholesterol efflux [GO:0033344]; cholesterol homeostasis [GO:0042632]; cholesterol import [GO:0070508]; cholesterol metabolic process [GO:0008203]; cholesterol transport [GO:0030301]; endothelial cell proliferation [GO:0001935]; glucocorticoid metabolic process [GO:0008211]; G protein-coupled receptor signaling pathway [GO:0007186]; high-density lipoprotein particle assembly [GO:0034380]; high-density lipoprotein particle clearance [GO:0034384]; high-density lipoprotein particle remodeling [GO:0034375]; integrin-mediated signaling pathway [GO:0007229]; lipid storage [GO:0019915]; lipoprotein biosynthetic process [GO:0042158]; lipoprotein metabolic process [GO:0042157]; negative chemotaxis [GO:0050919]; negative regulation of cell adhesion molecule production [GO:0060354]; negative regulation of cytokine production involved in immune response [GO:0002719]; negative regulation of heterotypic cell-cell adhesion [GO:0034115]; negative regulation of hydrolase activity [GO:0051346]; negative regulation of inflammatory response [GO:0050728]; negative regulation of interleukin-1 beta production [GO:0032691]; negative regulation of response to cytokine stimulus [GO:0060761]; negative regulation of tumor necrosis factor-mediated signaling pathway [GO:0010804]; negative regulation of very-low-density lipoprotein particle remodeling [GO:0010903]; peptidyl-methionine modification [GO:0018206]; phosphatidylcholine biosynthetic process [GO:0006656]; phosphatidylcholine metabolic process [GO:0046470]; phospholipid efflux [GO:0033700]; phospholipid homeostasis [GO:0055091]; positive regulation of cholesterol efflux [GO:0010875]; positive regulation of cholesterol esterification [GO:0010873]; positive regulation of fatty acid biosynthetic process [GO:0045723]; positive regulation of hydrolase activity [GO:0051345]; positive regulation of lipid biosynthetic process [GO:0046889]; positive regulation of lipoprotein lipase activity [GO:0051006]; positive regulation of phagocytosis [GO:0050766]; positive regulation of phospholipid efflux [GO:1902995]; positive regulation of Rho protein signal transduction [GO:0035025]; positive regulation of stress fiber assembly [GO:0051496]; positive regulation of substrate adhesion-dependent cell spreading [GO:1900026]; positive regulation of triglyceride catabolic process [GO:0010898]; protein oxidation [GO:0018158]; protein stabilization [GO:0050821]; regulation of Cdc42 protein signal transduction [GO:0032489]; regulation of intestinal cholesterol absorption [GO:0030300]; regulation of protein phosphorylation [GO:0001932]; reverse cholesterol transport [GO:0043691]; triglyceride homeostasis [GO:0070328]; very-low-density lipoprotein particle remodeling [GO:0034372]; vitamin transport [GO:0051180] View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R177C	TCGA-BR-8589	STAD	TCGA	LAPYSD	LIG_APCC_ABBA_1	187:192	Mutation rewiring degron network	0.0556
p.R177C	DO47813	STAD	ICGC	LAPYSD	LIG_APCC_ABBA_1	187:192	Mutation rewiring degron network	0.0556
p.S191N	TCGA-L5-A8NM	ESCA	TCGA	LAPYSD	LIG_APCC_ABBA_1	187:192	Mutation altering degron motif	0.7069
p.A199V	DO233282	GACA	ICGC	LAPYSD	LIG_APCC_ABBA_1	187:192	Mutation rewiring degron network	0.1389
p.R179G	ACH-000965	Endometrial/Uterine Cancer	CCLE	LAPYSD	LIG_APCC_ABBA_1	187:192	Mutation rewiring degron network	0.1111
p.R179G	RL95-2	endometrium	COSMIC	LAPYSD	LIG_APCC_ABBA_1	187:192	Mutation rewiring degron network	0.1111
p.R201G	RL95-2	endometrium	COSMIC	LAPYSD	LIG_APCC_ABBA_1	187:192	Mutation rewiring degron network	0.0833

DegronMD: protein-targeted degradation, mutation and drug response to degrons

APOA1

UniProt ID: P02647

Entrez ID: 335

Protein name: Apolipoprotein A-I (Apo-AI) (ApoA-I) (Apolipoprotein A1) [Cleaved into: Proapolipoprotein A-I (ProapoA-I); Truncated apolipoprotein A-I (Apolipoprotein A-I(1-242))]

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for APOA1 in