DegronMD

Uniprot ID: P02647

Source protein: Apolipoprotein A-I

Source gene: APOA1

Class: LIG_APCC_ABBA_1

Location: 187:192

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.886

ASA_SCORE: 56.2

COIL: 0.1347

CONS_SCORE: 0.7151

DSS_SCORE: 0.3454

HELIX: 0.862

FCONS_SCORE: 1.138

RIG_SCORE: 0.7679

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R177C	TCGA-BR-8589	STAD	TCGA	LAPYSD	LIG_APCC_ABBA_1	0.0556
p.R177C	DO47813	STAD	ICGC	LAPYSD	LIG_APCC_ABBA_1	0.0556
p.S191N	TCGA-L5-A8NM	ESCA	TCGA	LAPYSD	LIG_APCC_ABBA_1	0.7069
p.A199V	DO233282	GACA	ICGC	LAPYSD	LIG_APCC_ABBA_1	0.1389
p.R179G	ACH-000965	Endometrial/Uterine Cancer	CCLE	LAPYSD	LIG_APCC_ABBA_1	0.1111
p.R179G	RL95-2	endometrium	COSMIC	LAPYSD	LIG_APCC_ABBA_1	0.1111
p.R201G	RL95-2	endometrium	COSMIC	LAPYSD	LIG_APCC_ABBA_1	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P02647	Apolipoprotein A-I	LIG_APCC_ABBA_1	187:192	LAPYSD	APC,CDC20,FZR1	0.886	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons