DegronMD - P02787(TF)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.F321Y	TCGA-60-2713	LUSC	TCGA	KDLLFKD	LIG_APCC_ABBAyCdc20_2	310:316	Mutation rewiring degron network	0.1944
p.F321Y	DO26476	LUSC	ICGC	KDLLFKD	LIG_APCC_ABBAyCdc20_2	310:316	Mutation rewiring degron network	0.1944
p.V324F	TCGA-85-8582	LUSC	TCGA	KDLLFKD	LIG_APCC_ABBAyCdc20_2	310:316	Mutation rewiring degron network	0.1111
p.V324F	DO45491	LUSC	ICGC	KDLLFKD	LIG_APCC_ABBAyCdc20_2	310:316	Mutation rewiring degron network	0.1111
p.G320V	TCGA-A5-A1OF	UCEC	TCGA	KDLLFKD	LIG_APCC_ABBAyCdc20_2	310:316	Mutation rewiring degron network	0.2222
p.G320V	DO42568	UCEC	ICGC	KDLLFKD	LIG_APCC_ABBAyCdc20_2	310:316	Mutation rewiring degron network	0.2222
p.V324A	TCGA-BD-A2L6	LIHC	TCGA	KDLLFKD	LIG_APCC_ABBAyCdc20_2	310:316	Mutation rewiring degron network	0.1111
p.V324A	DO219551	LIHC	ICGC	KDLLFKD	LIG_APCC_ABBAyCdc20_2	310:316	Mutation rewiring degron network	0.1111
p.S317C	TCGA-CN-5374	HNSC	TCGA	KDLLFKD	LIG_APCC_ABBAyCdc20_2	310:316	Mutation rewiring degron network	0.3056
p.S317C	DO15430	HNSC	ICGC	KDLLFKD	LIG_APCC_ABBAyCdc20_2	310:316	Mutation rewiring degron network	0.3056
p.P307S	TCGA-FR-A726	SKCM	TCGA	KDLLFKD	LIG_APCC_ABBAyCdc20_2	310:316	Mutation rewiring degron network	0.25
p.P307S	DO48665	SKCM	ICGC	KDLLFKD	LIG_APCC_ABBAyCdc20_2	310:316	Mutation rewiring degron network	0.25
p.P307L	TCGA-FR-A726	SKCM	TCGA	KDLLFKD	LIG_APCC_ABBAyCdc20_2	310:316	Mutation rewiring degron network	0.25
p.P307L	DO48665	SKCM	ICGC	KDLLFKD	LIG_APCC_ABBAyCdc20_2	310:316	Mutation rewiring degron network	0.25
p.G309E	TCGA-GN-A267	SKCM	TCGA	KDLLFKD	LIG_APCC_ABBAyCdc20_2	310:316	Mutation rewiring degron network	0.3056
p.G309E	DO38147	SKCM	ICGC	KDLLFKD	LIG_APCC_ABBAyCdc20_2	310:316	Mutation rewiring degron network	0.3056
p.H319Q	TCGA-L9-A7SV	LUAD	TCGA	KDLLFKD	LIG_APCC_ABBAyCdc20_2	310:316	Mutation rewiring degron network	0.25
p.H319Q	DO49875	LUAD	ICGC	KDLLFKD	LIG_APCC_ABBAyCdc20_2	310:316	Mutation rewiring degron network	0.25
p.I321V	DO229010	COCA	ICGC	KDLLFKD	LIG_APCC_ABBAyCdc20_2	310:316	Mutation rewiring degron network	0.1944
p.I321V	DO229013	COCA	ICGC	KDLLFKD	LIG_APCC_ABBAyCdc20_2	310:316	Mutation rewiring degron network	0.1944
p.I321V	DO229016	COCA	ICGC	KDLLFKD	LIG_APCC_ABBAyCdc20_2	310:316	Mutation rewiring degron network	0.1944
p.I321V	DO229003	COCA	ICGC	KDLLFKD	LIG_APCC_ABBAyCdc20_2	310:316	Mutation rewiring degron network	0.1944
p.I321V	DO229005	COCA	ICGC	KDLLFKD	LIG_APCC_ABBAyCdc20_2	310:316	Mutation rewiring degron network	0.1944
p.A320S	DO234159	ESAD	ICGC	KDLLFKD	LIG_APCC_ABBAyCdc20_2	310:316	Mutation rewiring degron network	0.2222
p.D311Y	DO44680	LICA	ICGC	KDLLFKD	LIG_APCC_ABBAyCdc20_2	310:316	Mutation altering degron motif	0.6214
p.D308G	DO231524	LINC	ICGC	KDLLFKD	LIG_APCC_ABBAyCdc20_2	310:316	Mutation rewiring degron network	0.2778
p.E311K	DO50842	LIRI	ICGC	KDLLFKD	LIG_APCC_ABBAyCdc20_2	310:316	Mutation altering degron motif	0.7022
p.P325L	DO220899	MELA	ICGC	KDLLFKD	LIG_APCC_ABBAyCdc20_2	310:316	Mutation rewiring degron network	0.0833
p.P314L	DO27883	ORCA	ICGC	KDLLFKD	LIG_APCC_ABBAyCdc20_2	310:316	Mutation altering degron motif	0.7582
p.C310F	DO31574	OV	ICGC	KDLLFKD	LIG_APCC_ABBAyCdc20_2	310:316	Mutation altering degron motif	0.7108
p.P326S	DO229479	SKCA	ICGC	KDLLFKD	LIG_APCC_ABBAyCdc20_2	310:316	Mutation rewiring degron network	0.0556
p.D308N	DO37891	SKCM	ICGC	KDLLFKD	LIG_APCC_ABBAyCdc20_2	310:316	Mutation rewiring degron network	0.2778
p.D308N	DO41379	UCEC	ICGC	KDLLFKD	LIG_APCC_ABBAyCdc20_2	310:316	Mutation rewiring degron network	0.2778
p.E315D	DO41999	UCEC	ICGC	KDLLFKD	LIG_APCC_ABBAyCdc20_2	310:316	Mutation altering degron motif	0.6758
p.K325N	DO41799	UCEC	ICGC	KDLLFKD	LIG_APCC_ABBAyCdc20_2	310:316	Mutation rewiring degron network	0.0833
p.T313I	DO41319	UCEC	ICGC	KDLLFKD	LIG_APCC_ABBAyCdc20_2	310:316	Mutation altering degron motif	0.7078
p.H319R	SIDM00958	Chronic Myelogenous Leukemia	GDSC	KDLLFKD	LIG_APCC_ABBAyCdc20_2	310:316	Mutation rewiring degron network	0.25
p.H319R	SIDM01030	Esophageal Squamous Cell Carcinoma	GDSC	KDLLFKD	LIG_APCC_ABBAyCdc20_2	310:316	Mutation rewiring degron network	0.25
p.H319R	SIDM00600	Thyroid Gland Carcinoma	GDSC	KDLLFKD	LIG_APCC_ABBAyCdc20_2	310:316	Mutation rewiring degron network	0.25
p.H319R	SIDM01199	Hepatocellular Carcinoma	GDSC	KDLLFKD	LIG_APCC_ABBAyCdc20_2	310:316	Mutation rewiring degron network	0.25
p.H319R	SIDM01194	Hepatocellular Carcinoma	GDSC	KDLLFKD	LIG_APCC_ABBAyCdc20_2	310:316	Mutation rewiring degron network	0.25
p.H319R	SIDM00410	Other Blood Cancers	GDSC	KDLLFKD	LIG_APCC_ABBAyCdc20_2	310:316	Mutation rewiring degron network	0.25
p.H319R	SIDM01217	Other Blood Cancers	GDSC	KDLLFKD	LIG_APCC_ABBAyCdc20_2	310:316	Mutation rewiring degron network	0.25
p.H319R	SIDM01193	Glioma	GDSC	KDLLFKD	LIG_APCC_ABBAyCdc20_2	310:316	Mutation rewiring degron network	0.25
p.H319R	SIDM01018	Hodgkin's Lymphoma	GDSC	KDLLFKD	LIG_APCC_ABBAyCdc20_2	310:316	Mutation rewiring degron network	0.25
p.H319R	SIDM01446	Glioblastoma	GDSC	KDLLFKD	LIG_APCC_ABBAyCdc20_2	310:316	Mutation rewiring degron network	0.25
p.G309V	SIDM01158	Squamous Cell Lung Carcinoma	GDSC	KDLLFKD	LIG_APCC_ABBAyCdc20_2	310:316	Mutation rewiring degron network	0.3056
p.G309V	ACH-000669	Lung Cancer	CCLE	KDLLFKD	LIG_APCC_ABBAyCdc20_2	310:316	Mutation rewiring degron network	0.3056
p.G309V	SW900	lung	COSMIC	KDLLFKD	LIG_APCC_ABBAyCdc20_2	310:316	Mutation rewiring degron network	0.3056
p.P325S	ACH-001568	Skin Cancer	CCLE	KDLLFKD	LIG_APCC_ABBAyCdc20_2	310:316	Mutation rewiring degron network	0.0833

Kaplan plot for TF in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

TF

UniProt ID: P02787

Entrez ID: 7018

Protein name: Serotransferrin (Transferrin) (Beta-1 metal-binding globulin) (Siderophilin)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for TF in