DegronMD

Uniprot ID: P02787

Source protein: Serotransferrin

Source gene: TF

Class: LIG_APCC_ABBAyCdc20_2

Location: 310:316

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9518

ASA_SCORE: 63.1286

COIL: 0.5013

CONS_SCORE: 0.7213

DSS_SCORE: 0.253

HELIX: 0.4089

FCONS_SCORE: 1.4071

RIG_SCORE: 0.7545

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.F321Y	TCGA-60-2713	LUSC	TCGA	KDLLFKD	LIG_APCC_ABBAyCdc20_2	0.1944
p.F321Y	DO26476	LUSC	ICGC	KDLLFKD	LIG_APCC_ABBAyCdc20_2	0.1944
p.V324F	TCGA-85-8582	LUSC	TCGA	KDLLFKD	LIG_APCC_ABBAyCdc20_2	0.1111
p.V324F	DO45491	LUSC	ICGC	KDLLFKD	LIG_APCC_ABBAyCdc20_2	0.1111
p.G320V	TCGA-A5-A1OF	UCEC	TCGA	KDLLFKD	LIG_APCC_ABBAyCdc20_2	0.2222
p.G320V	DO42568	UCEC	ICGC	KDLLFKD	LIG_APCC_ABBAyCdc20_2	0.2222
p.V324A	TCGA-BD-A2L6	LIHC	TCGA	KDLLFKD	LIG_APCC_ABBAyCdc20_2	0.1111
p.V324A	DO219551	LIHC	ICGC	KDLLFKD	LIG_APCC_ABBAyCdc20_2	0.1111
p.S317C	TCGA-CN-5374	HNSC	TCGA	KDLLFKD	LIG_APCC_ABBAyCdc20_2	0.3056
p.S317C	DO15430	HNSC	ICGC	KDLLFKD	LIG_APCC_ABBAyCdc20_2	0.3056
p.P307S	TCGA-FR-A726	SKCM	TCGA	KDLLFKD	LIG_APCC_ABBAyCdc20_2	0.25
p.P307S	DO48665	SKCM	ICGC	KDLLFKD	LIG_APCC_ABBAyCdc20_2	0.25
p.P307L	TCGA-FR-A726	SKCM	TCGA	KDLLFKD	LIG_APCC_ABBAyCdc20_2	0.25
p.P307L	DO48665	SKCM	ICGC	KDLLFKD	LIG_APCC_ABBAyCdc20_2	0.25
p.G309E	TCGA-GN-A267	SKCM	TCGA	KDLLFKD	LIG_APCC_ABBAyCdc20_2	0.3056
p.G309E	DO38147	SKCM	ICGC	KDLLFKD	LIG_APCC_ABBAyCdc20_2	0.3056
p.H319Q	TCGA-L9-A7SV	LUAD	TCGA	KDLLFKD	LIG_APCC_ABBAyCdc20_2	0.25
p.H319Q	DO49875	LUAD	ICGC	KDLLFKD	LIG_APCC_ABBAyCdc20_2	0.25
p.I321V	DO229010	COCA	ICGC	KDLLFKD	LIG_APCC_ABBAyCdc20_2	0.1944
p.I321V	DO229013	COCA	ICGC	KDLLFKD	LIG_APCC_ABBAyCdc20_2	0.1944
p.I321V	DO229016	COCA	ICGC	KDLLFKD	LIG_APCC_ABBAyCdc20_2	0.1944
p.I321V	DO229003	COCA	ICGC	KDLLFKD	LIG_APCC_ABBAyCdc20_2	0.1944
p.I321V	DO229005	COCA	ICGC	KDLLFKD	LIG_APCC_ABBAyCdc20_2	0.1944
p.A320S	DO234159	ESAD	ICGC	KDLLFKD	LIG_APCC_ABBAyCdc20_2	0.2222
p.D311Y	DO44680	LICA	ICGC	KDLLFKD	LIG_APCC_ABBAyCdc20_2	0.6214
p.D308G	DO231524	LINC	ICGC	KDLLFKD	LIG_APCC_ABBAyCdc20_2	0.2778
p.E311K	DO50842	LIRI	ICGC	KDLLFKD	LIG_APCC_ABBAyCdc20_2	0.7022
p.P325L	DO220899	MELA	ICGC	KDLLFKD	LIG_APCC_ABBAyCdc20_2	0.0833
p.P314L	DO27883	ORCA	ICGC	KDLLFKD	LIG_APCC_ABBAyCdc20_2	0.7582
p.C310F	DO31574	OV	ICGC	KDLLFKD	LIG_APCC_ABBAyCdc20_2	0.7108
p.P326S	DO229479	SKCA	ICGC	KDLLFKD	LIG_APCC_ABBAyCdc20_2	0.0556
p.D308N	DO37891	SKCM	ICGC	KDLLFKD	LIG_APCC_ABBAyCdc20_2	0.2778
p.D308N	DO41379	UCEC	ICGC	KDLLFKD	LIG_APCC_ABBAyCdc20_2	0.2778
p.E315D	DO41999	UCEC	ICGC	KDLLFKD	LIG_APCC_ABBAyCdc20_2	0.6758
p.K325N	DO41799	UCEC	ICGC	KDLLFKD	LIG_APCC_ABBAyCdc20_2	0.0833
p.T313I	DO41319	UCEC	ICGC	KDLLFKD	LIG_APCC_ABBAyCdc20_2	0.7078
p.H319R	SIDM00958	Chronic Myelogenous Leukemia	GDSC	KDLLFKD	LIG_APCC_ABBAyCdc20_2	0.25
p.H319R	SIDM01030	Esophageal Squamous Cell Carcinoma	GDSC	KDLLFKD	LIG_APCC_ABBAyCdc20_2	0.25
p.H319R	SIDM00600	Thyroid Gland Carcinoma	GDSC	KDLLFKD	LIG_APCC_ABBAyCdc20_2	0.25
p.H319R	SIDM01199	Hepatocellular Carcinoma	GDSC	KDLLFKD	LIG_APCC_ABBAyCdc20_2	0.25
p.H319R	SIDM01194	Hepatocellular Carcinoma	GDSC	KDLLFKD	LIG_APCC_ABBAyCdc20_2	0.25
p.H319R	SIDM00410	Other Blood Cancers	GDSC	KDLLFKD	LIG_APCC_ABBAyCdc20_2	0.25
p.H319R	SIDM01217	Other Blood Cancers	GDSC	KDLLFKD	LIG_APCC_ABBAyCdc20_2	0.25
p.H319R	SIDM01193	Glioma	GDSC	KDLLFKD	LIG_APCC_ABBAyCdc20_2	0.25
p.H319R	SIDM01018	Hodgkin's Lymphoma	GDSC	KDLLFKD	LIG_APCC_ABBAyCdc20_2	0.25
p.H319R	SIDM01446	Glioblastoma	GDSC	KDLLFKD	LIG_APCC_ABBAyCdc20_2	0.25
p.G309V	SIDM01158	Squamous Cell Lung Carcinoma	GDSC	KDLLFKD	LIG_APCC_ABBAyCdc20_2	0.3056
p.G309V	ACH-000669	Lung Cancer	CCLE	KDLLFKD	LIG_APCC_ABBAyCdc20_2	0.3056
p.G309V	SW900	lung	COSMIC	KDLLFKD	LIG_APCC_ABBAyCdc20_2	0.3056
p.P325S	ACH-001568	Skin Cancer	CCLE	KDLLFKD	LIG_APCC_ABBAyCdc20_2	0.0833

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: KDLLFKD

Degron related mutations and impact score

Drug responses associated with TF mutations

All proteins holding degron of KDLLFKD

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P02787	Serotransferrin	LIG_APCC_ABBAyCdc20_2	310:316	KDLLFKD	APC,CDC20,FZR1	0.9518	More...