DegronMD - P03951(F11)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.W519S	TCGA-55-7994	LUAD	TCGA	RNVIYTD	LIG_APCC_ABBAyCdc20_2	507:513	Mutation rewiring degron network	0.1667
p.S503C	TCGA-60-2698	LUSC	TCGA	RNVIYTD	LIG_APCC_ABBAyCdc20_2	507:513	Mutation rewiring degron network	0.2222
p.R522I	TCGA-AJ-A3EL	UCEC	TCGA	RNVIYTD	LIG_APCC_ABBAyCdc20_2	507:513	Mutation rewiring degron network	0.0833
p.R522I	TCGA-AX-A1CE	UCEC	TCGA	RNVIYTD	LIG_APCC_ABBAyCdc20_2	507:513	Mutation rewiring degron network	0.0833
p.R522K	TCGA-AN-A046	BRCA	TCGA	RNVIYTD	LIG_APCC_ABBAyCdc20_2	507:513	Mutation rewiring degron network	0.0833
p.V509A	TCGA-B5-A3FA	UCEC	TCGA	RNVIYTD	LIG_APCC_ABBAyCdc20_2	507:513	Mutation altering degron motif	0.5825
p.D513N	TCGA-QQ-A5VD	SARC	TCGA	RNVIYTD	LIG_APCC_ABBAyCdc20_2	507:513	Mutation altering degron motif	0.6932
p.M506K	DO50288	SKCM	ICGC	RNVIYTD	LIG_APCC_ABBAyCdc20_2	507:513	Mutation rewiring degron network	0.3056
p.D506N	SIDM00007	Other Solid Cancers	GDSC	RNVIYTD	LIG_APCC_ABBAyCdc20_2	507:513	Mutation rewiring degron network	0.3056
p.D506N	ACH-001550	Skin Cancer	CCLE	RNVIYTD	LIG_APCC_ABBAyCdc20_2	507:513	Mutation rewiring degron network	0.3056
p.D506N	MCC13	skin	COSMIC	RNVIYTD	LIG_APCC_ABBAyCdc20_2	507:513	Mutation rewiring degron network	0.3056
p.R507K	SIDM01588	Endometrial Carcinoma	GDSC	RNVIYTD	LIG_APCC_ABBAyCdc20_2	507:513	Mutation altering degron motif	0.6126
p.R507K	ACH-000993	Endometrial/Uterine Cancer	CCLE	RNVIYTD	LIG_APCC_ABBAyCdc20_2	507:513	Mutation altering degron motif	0.6126
p.S521L	HCC2998	large intestine	COSMIC	RNVIYTD	LIG_APCC_ABBAyCdc20_2	507:513	Mutation blocking phosphorylation signal	0.5556

Kaplan plot for F11 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

F11

UniProt ID: P03951

Entrez ID: 2160

Protein name: Coagulation factor XI (FXI) (EC 3.4.21.27) (Plasma thromboplastin antecedent) (PTA) [Cleaved into: Coagulation factor XIa heavy chain; Coagulation factor XIa light chain]

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for F11 in