DegronMD

Uniprot ID: P03951

Source protein: Coagulation factor XI

Source gene: F11

Class: LIG_APCC_ABBAyCdc20_2

Location: 507:513

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9542

ASA_SCORE: 72.9

COIL: 0.7447

CONS_SCORE: 0.3993

DSS_SCORE: 0.105

HELIX: 0.0096

FCONS_SCORE: 0.6082

RIG_SCORE: 0.892

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.W519S	TCGA-55-7994	LUAD	TCGA	RNVIYTD	LIG_APCC_ABBAyCdc20_2	0.1667
p.S503C	TCGA-60-2698	LUSC	TCGA	RNVIYTD	LIG_APCC_ABBAyCdc20_2	0.2222
p.R522I	TCGA-AJ-A3EL	UCEC	TCGA	RNVIYTD	LIG_APCC_ABBAyCdc20_2	0.0833
p.R522I	TCGA-AX-A1CE	UCEC	TCGA	RNVIYTD	LIG_APCC_ABBAyCdc20_2	0.0833
p.R522K	TCGA-AN-A046	BRCA	TCGA	RNVIYTD	LIG_APCC_ABBAyCdc20_2	0.0833
p.V509A	TCGA-B5-A3FA	UCEC	TCGA	RNVIYTD	LIG_APCC_ABBAyCdc20_2	0.5825
p.D513N	TCGA-QQ-A5VD	SARC	TCGA	RNVIYTD	LIG_APCC_ABBAyCdc20_2	0.6932
p.M506K	DO50288	SKCM	ICGC	RNVIYTD	LIG_APCC_ABBAyCdc20_2	0.3056
p.D506N	SIDM00007	Other Solid Cancers	GDSC	RNVIYTD	LIG_APCC_ABBAyCdc20_2	0.3056
p.D506N	ACH-001550	Skin Cancer	CCLE	RNVIYTD	LIG_APCC_ABBAyCdc20_2	0.3056
p.D506N	MCC13	skin	COSMIC	RNVIYTD	LIG_APCC_ABBAyCdc20_2	0.3056
p.R507K	SIDM01588	Endometrial Carcinoma	GDSC	RNVIYTD	LIG_APCC_ABBAyCdc20_2	0.6126
p.R507K	ACH-000993	Endometrial/Uterine Cancer	CCLE	RNVIYTD	LIG_APCC_ABBAyCdc20_2	0.6126
p.S521L	HCC2998	large_intestine	COSMIC	RNVIYTD	LIG_APCC_ABBAyCdc20_2	0.5556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P03951	Coagulation factor XI	LIG_APCC_ABBAyCdc20_2	507:513	RNVIYTD	APC,CDC20,FZR1	0.9542	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons