DegronMD - P04053(DNTT)

GO - Biological processes (BP): View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

Choose a PDB ID:
Open in full screen with detailed sequence annotations

Data table is loading....

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.K370N	TCGA-AA-A010	COAD	TCGA	LLLYYD	LIG_APCC_ABBA_1	373:378	Mutation blocking ubiquitination signal	0.6944
p.L367V	TCGA-AN-A046	BRCA	TCGA	LLLYYD	LIG_APCC_ABBA_1	373:378	Mutation rewiring degron network	0.1667
p.L367V	DO1285	BRCA	ICGC	LLLYYD	LIG_APCC_ABBA_1	373:378	Mutation rewiring degron network	0.1667
p.E385G	TCGA-AP-A056	UCEC	TCGA	LLLYYD	LIG_APCC_ABBA_1	373:378	Mutation rewiring degron network	0.1389
p.E385G	DO43971	UCEC	ICGC	LLLYYD	LIG_APCC_ABBA_1	373:378	Mutation rewiring degron network	0.1389
p.N366D	TCGA-FI-A2D5	UCEC	TCGA	LLLYYD	LIG_APCC_ABBA_1	373:378	Mutation rewiring degron network	0.1389
p.N366D	DO41331	UCEC	ICGC	LLLYYD	LIG_APCC_ABBA_1	373:378	Mutation rewiring degron network	0.1389
p.D378H	TCGA-R3-A69X	BLCA	TCGA	LLLYYD	LIG_APCC_ABBA_1	373:378	Mutation altering degron motif	0.7688
p.D378H	DO51902	BLCA	ICGC	LLLYYD	LIG_APCC_ABBA_1	373:378	Mutation altering degron motif	0.7688
p.E381Q	TCGA-R3-A69X	BLCA	TCGA	LLLYYD	LIG_APCC_ABBA_1	373:378	Mutation rewiring degron network	0.25
p.E381Q	DO51902	BLCA	ICGC	LLLYYD	LIG_APCC_ABBA_1	373:378	Mutation rewiring degron network	0.25
p.V364M	DO11854	GBM	ICGC	LLLYYD	LIG_APCC_ABBA_1	373:378	Mutation rewiring degron network	0.0833
p.Y376H	SIDM00860	Head and Neck Carcinoma	GDSC	LLLYYD	LIG_APCC_ABBA_1	373:378	Mutation altering degron motif	0.6118
p.Y376H	FADU	upper aerodigestive tract	COSMIC	LLLYYD	LIG_APCC_ABBA_1	373:378	Mutation altering degron motif	0.6118
p.E381K	SIDM01000	Melanoma	GDSC	LLLYYD	LIG_APCC_ABBA_1	373:378	Mutation rewiring degron network	0.25
p.E381K	ACH-000304	Skin Cancer	CCLE	LLLYYD	LIG_APCC_ABBA_1	373:378	Mutation rewiring degron network	0.25
p.E381K	WM-115	skin	COSMIC	LLLYYD	LIG_APCC_ABBA_1	373:378	Mutation rewiring degron network	0.25
p.L374R	ACH-001068	Lymphoma	CCLE	LLLYYD	LIG_APCC_ABBA_1	373:378	Mutation altering degron motif	0.7316

Kaplan plot for DNTT in

Select cancer type:
Download patient class data (Lower:Upper = 50%:50%)

*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

DNTT

UniProt ID: P04053

Entrez ID: 1791

Protein name: DNA nucleotidylexotransferase (EC 2.7.7.31) (Terminal addition enzyme) (Terminal deoxynucleotidyltransferase) (Terminal transferase)

External links: UniprotKB HGNC RefSeq COSMIC

Data table is loading....

Kaplan plot for DNTT in