DegronMD

Uniprot ID: P04053

Source protein: DNA nucleotidylexotransferase

Source gene: DNTT

Class: LIG_APCC_ABBA_1

Location: 373:378

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.6046

ASA_SCORE: 55.5167

COIL: 0.4998

CONS_SCORE: 0.394

DSS_SCORE: 0.0261

HELIX: 0.3452

FCONS_SCORE: 1.0381

RIG_SCORE: 0.9448

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.K370N	TCGA-AA-A010	COAD	TCGA	LLLYYD	LIG_APCC_ABBA_1	0.6944
p.L367V	TCGA-AN-A046	BRCA	TCGA	LLLYYD	LIG_APCC_ABBA_1	0.1667
p.L367V	DO1285	BRCA	ICGC	LLLYYD	LIG_APCC_ABBA_1	0.1667
p.E385G	TCGA-AP-A056	UCEC	TCGA	LLLYYD	LIG_APCC_ABBA_1	0.1389
p.E385G	DO43971	UCEC	ICGC	LLLYYD	LIG_APCC_ABBA_1	0.1389
p.N366D	TCGA-FI-A2D5	UCEC	TCGA	LLLYYD	LIG_APCC_ABBA_1	0.1389
p.N366D	DO41331	UCEC	ICGC	LLLYYD	LIG_APCC_ABBA_1	0.1389
p.D378H	TCGA-R3-A69X	BLCA	TCGA	LLLYYD	LIG_APCC_ABBA_1	0.7688
p.D378H	DO51902	BLCA	ICGC	LLLYYD	LIG_APCC_ABBA_1	0.7688
p.E381Q	TCGA-R3-A69X	BLCA	TCGA	LLLYYD	LIG_APCC_ABBA_1	0.25
p.E381Q	DO51902	BLCA	ICGC	LLLYYD	LIG_APCC_ABBA_1	0.25
p.V364M	DO11854	GBM	ICGC	LLLYYD	LIG_APCC_ABBA_1	0.0833
p.Y376H	SIDM00860	Head and Neck Carcinoma	GDSC	LLLYYD	LIG_APCC_ABBA_1	0.6118
p.Y376H	FADU	upper_aerodigestive_tract	COSMIC	LLLYYD	LIG_APCC_ABBA_1	0.6118
p.E381K	SIDM01000	Melanoma	GDSC	LLLYYD	LIG_APCC_ABBA_1	0.25
p.E381K	ACH-000304	Skin Cancer	CCLE	LLLYYD	LIG_APCC_ABBA_1	0.25
p.E381K	WM-115	skin	COSMIC	LLLYYD	LIG_APCC_ABBA_1	0.25
p.L374R	ACH-001068	Lymphoma	CCLE	LLLYYD	LIG_APCC_ABBA_1	0.7316

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P04053	DNA nucleotidylexotransferase	LIG_APCC_ABBA_1	373:378	LLLYYD	APC,CDC20,FZR1	0.6046	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons