DegronMD - P04070(PROC)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.M406V	TCGA-AN-A0AT	BRCA	TCGA	FHGTWFLV	DEG_MDM2_SWIB_1	410:417	Mutation rewiring degron network	0.2222
p.A408S	TCGA-CG-4460	STAD	TCGA	FHGTWFLV	DEG_MDM2_SWIB_1	410:417	Mutation rewiring degron network	0.2778
p.G412S	TCGA-XV-AAZV	SKCM	TCGA	FHGTWFLV	DEG_MDM2_SWIB_1	410:417	Mutation altering degron motif	0.5882
p.H400Q	DO8344	COAD	ICGC	FHGTWFLV	DEG_MDM2_SWIB_1	410:417	Mutation rewiring degron network	0.0556
p.V414I	DO230342	COCA	ICGC	FHGTWFLV	DEG_MDM2_SWIB_1	410:417	Mutation altering degron motif	0.7076
p.V414I	DO42408	UCEC	ICGC	FHGTWFLV	DEG_MDM2_SWIB_1	410:417	Mutation altering degron motif	0.7076
p.V422M	DO234267	ESAD	ICGC	FHGTWFLV	DEG_MDM2_SWIB_1	410:417	Mutation rewiring degron network	0.1944
p.V414A	DO233254	GACA	ICGC	FHGTWFLV	DEG_MDM2_SWIB_1	410:417	Mutation altering degron motif	0.6936
p.S402N	DO233764	GACA	ICGC	FHGTWFLV	DEG_MDM2_SWIB_1	410:417	Mutation rewiring degron network	0.1111
p.S402N	SIDM00596	Endometrial Carcinoma	GDSC	FHGTWFLV	DEG_MDM2_SWIB_1	410:417	Mutation rewiring degron network	0.1111
p.S402N	ACH-001517	Endometrial/Uterine Cancer	CCLE	FHGTWFLV	DEG_MDM2_SWIB_1	410:417	Mutation rewiring degron network	0.1111
p.S402N	HEC-1	endometrium	COSMIC	FHGTWFLV	DEG_MDM2_SWIB_1	410:417	Mutation rewiring degron network	0.1111
p.R403L	DO228976	LICA	ICGC	FHGTWFLV	DEG_MDM2_SWIB_1	410:417	Mutation rewiring degron network	0.1389
p.R409K	DO49875	LUAD	ICGC	FHGTWFLV	DEG_MDM2_SWIB_1	410:417	Mutation rewiring degron network	0.3056
p.R409K	DO37831	SKCM	ICGC	FHGTWFLV	DEG_MDM2_SWIB_1	410:417	Mutation rewiring degron network	0.3056
p.P421S	DO222749	MELA	ICGC	FHGTWFLV	DEG_MDM2_SWIB_1	410:417	Mutation rewiring degron network	0.2222
p.P424S	DO38022	SKCM	ICGC	FHGTWFLV	DEG_MDM2_SWIB_1	410:417	Mutation rewiring degron network	0.1389
p.G412D	SIDM01071	Small Cell Lung Carcinoma	GDSC	FHGTWFLV	DEG_MDM2_SWIB_1	410:417	Mutation altering degron motif	0.6087
p.G412D	ACH-000515	Lung Cancer	CCLE	FHGTWFLV	DEG_MDM2_SWIB_1	410:417	Mutation altering degron motif	0.6087
p.G412D	HCC-33	lung	COSMIC	FHGTWFLV	DEG_MDM2_SWIB_1	410:417	Mutation altering degron motif	0.6087
p.V420L	SIDM00744	Non-Small Cell Lung Carcinoma	GDSC	FHGTWFLV	DEG_MDM2_SWIB_1	410:417	Mutation rewiring degron network	0.25
p.V420L	ACH-000893	Lung Cancer	CCLE	FHGTWFLV	DEG_MDM2_SWIB_1	410:417	Mutation rewiring degron network	0.25
p.V420L	NCI-H1651	lung	COSMIC	FHGTWFLV	DEG_MDM2_SWIB_1	410:417	Mutation rewiring degron network	0.25
p.A422V	SNU-407	large intestine	COSMIC	FHGTWFLV	DEG_MDM2_SWIB_1	410:417	Mutation rewiring degron network	0.1944

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

PROC

UniProt ID: P04070

Entrez ID: 5624

Protein name: Vitamin K-dependent protein C (EC 3.4.21.69) (Anticoagulant protein C) (Autoprothrombin IIA) (Blood coagulation factor XIV) [Cleaved into: Vitamin K-dependent protein C light chain; Vitamin K-dependent protein C heavy chain; Activation peptide]

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for PROC in