DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
FHGTWFLV
Uniprot ID:
P04070
Source protein:
Vitamin K-dependent protein C
Source gene:
PROC
Class:
DEG_MDM2_SWIB_1
Location:
410:417
E3 ligase:
MDM2
DEGRON score:
0.7194
ASA_SCORE:
48.825
COIL:
0.2553
CONS_SCORE:
0.6751
DSS_SCORE:
0.0465
HELIX:
0.0015
FCONS_SCORE:
0.8321
RIG_SCORE:
0.9111
Degron related mutations and impact score
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Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.V414I
DO230342
COCA
ICGC
FHGTWFLV
DEG_MDM2_SWIB_1
0.7076
p.V414I
DO42408
UCEC
ICGC
FHGTWFLV
DEG_MDM2_SWIB_1
0.7076
p.V414A
DO233254
GACA
ICGC
FHGTWFLV
DEG_MDM2_SWIB_1
0.6936
p.G412D
SIDM01071
Small Cell Lung Carcinoma
GDSC
FHGTWFLV
DEG_MDM2_SWIB_1
0.6087
p.G412D
ACH-000515
Lung Cancer
CCLE
FHGTWFLV
DEG_MDM2_SWIB_1
0.6087
p.G412D
HCC-33
lung
COSMIC
FHGTWFLV
DEG_MDM2_SWIB_1
0.6087
p.G412S
TCGA-XV-AAZV
SKCM
TCGA
FHGTWFLV
DEG_MDM2_SWIB_1
0.5882
p.R409K
DO49875
LUAD
ICGC
FHGTWFLV
DEG_MDM2_SWIB_1
0.3056
p.R409K
DO37831
SKCM
ICGC
FHGTWFLV
DEG_MDM2_SWIB_1
0.3056
p.A408S
TCGA-CG-4460
STAD
TCGA
FHGTWFLV
DEG_MDM2_SWIB_1
0.2778
p.V420L
SIDM00744
Non-Small Cell Lung Carcinoma
GDSC
FHGTWFLV
DEG_MDM2_SWIB_1
0.25
p.V420L
ACH-000893
Lung Cancer
CCLE
FHGTWFLV
DEG_MDM2_SWIB_1
0.25
p.V420L
NCI-H1651
lung
COSMIC
FHGTWFLV
DEG_MDM2_SWIB_1
0.25
p.M406V
TCGA-AN-A0AT
BRCA
TCGA
FHGTWFLV
DEG_MDM2_SWIB_1
0.2222
p.P421S
DO222749
MELA
ICGC
FHGTWFLV
DEG_MDM2_SWIB_1
0.2222
p.V422M
DO234267
ESAD
ICGC
FHGTWFLV
DEG_MDM2_SWIB_1
0.1944
p.A422V
SNU-407
large_intestine
COSMIC
FHGTWFLV
DEG_MDM2_SWIB_1
0.1944
p.R403L
DO228976
LICA
ICGC
FHGTWFLV
DEG_MDM2_SWIB_1
0.1389
p.P424S
DO38022
SKCM
ICGC
FHGTWFLV
DEG_MDM2_SWIB_1
0.1389
p.S402N
DO233764
GACA
ICGC
FHGTWFLV
DEG_MDM2_SWIB_1
0.1111
p.S402N
SIDM00596
Endometrial Carcinoma
GDSC
FHGTWFLV
DEG_MDM2_SWIB_1
0.1111
p.S402N
ACH-001517
Endometrial/Uterine Cancer
CCLE
FHGTWFLV
DEG_MDM2_SWIB_1
0.1111
p.S402N
HEC-1
endometrium
COSMIC
FHGTWFLV
DEG_MDM2_SWIB_1
0.1111
p.H400Q
DO8344
COAD
ICGC
FHGTWFLV
DEG_MDM2_SWIB_1
0.0556
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Drug responses associated with PROC mutations
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Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
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All proteins holding degron of FHGTWFLV
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Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
P04070
Vitamin K-dependent protein C
DEG_MDM2_SWIB_1
410:417
FHGTWFLV
MDM2
0.7194
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