DegronMD

Uniprot ID: P04070

Source protein: Vitamin K-dependent protein C

Source gene: PROC

Class: DEG_MDM2_SWIB_1

Location: 410:417

E3 ligase: MDM2

DEGRON score: 0.7194

ASA_SCORE: 48.825

COIL: 0.2553

CONS_SCORE: 0.6751

DSS_SCORE: 0.0465

HELIX: 0.0015

FCONS_SCORE: 0.8321

RIG_SCORE: 0.9111

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.M406V	TCGA-AN-A0AT	BRCA	TCGA	FHGTWFLV	DEG_MDM2_SWIB_1	0.2222
p.A408S	TCGA-CG-4460	STAD	TCGA	FHGTWFLV	DEG_MDM2_SWIB_1	0.2778
p.G412S	TCGA-XV-AAZV	SKCM	TCGA	FHGTWFLV	DEG_MDM2_SWIB_1	0.5882
p.H400Q	DO8344	COAD	ICGC	FHGTWFLV	DEG_MDM2_SWIB_1	0.0556
p.V414I	DO230342	COCA	ICGC	FHGTWFLV	DEG_MDM2_SWIB_1	0.7076
p.V414I	DO42408	UCEC	ICGC	FHGTWFLV	DEG_MDM2_SWIB_1	0.7076
p.V422M	DO234267	ESAD	ICGC	FHGTWFLV	DEG_MDM2_SWIB_1	0.1944
p.V414A	DO233254	GACA	ICGC	FHGTWFLV	DEG_MDM2_SWIB_1	0.6936
p.S402N	DO233764	GACA	ICGC	FHGTWFLV	DEG_MDM2_SWIB_1	0.1111
p.S402N	SIDM00596	Endometrial Carcinoma	GDSC	FHGTWFLV	DEG_MDM2_SWIB_1	0.1111
p.S402N	ACH-001517	Endometrial/Uterine Cancer	CCLE	FHGTWFLV	DEG_MDM2_SWIB_1	0.1111
p.S402N	HEC-1	endometrium	COSMIC	FHGTWFLV	DEG_MDM2_SWIB_1	0.1111
p.R403L	DO228976	LICA	ICGC	FHGTWFLV	DEG_MDM2_SWIB_1	0.1389
p.R409K	DO49875	LUAD	ICGC	FHGTWFLV	DEG_MDM2_SWIB_1	0.3056
p.R409K	DO37831	SKCM	ICGC	FHGTWFLV	DEG_MDM2_SWIB_1	0.3056
p.P421S	DO222749	MELA	ICGC	FHGTWFLV	DEG_MDM2_SWIB_1	0.2222
p.P424S	DO38022	SKCM	ICGC	FHGTWFLV	DEG_MDM2_SWIB_1	0.1389
p.G412D	SIDM01071	Small Cell Lung Carcinoma	GDSC	FHGTWFLV	DEG_MDM2_SWIB_1	0.6087
p.G412D	ACH-000515	Lung Cancer	CCLE	FHGTWFLV	DEG_MDM2_SWIB_1	0.6087
p.G412D	HCC-33	lung	COSMIC	FHGTWFLV	DEG_MDM2_SWIB_1	0.6087
p.V420L	SIDM00744	Non-Small Cell Lung Carcinoma	GDSC	FHGTWFLV	DEG_MDM2_SWIB_1	0.25
p.V420L	ACH-000893	Lung Cancer	CCLE	FHGTWFLV	DEG_MDM2_SWIB_1	0.25
p.V420L	NCI-H1651	lung	COSMIC	FHGTWFLV	DEG_MDM2_SWIB_1	0.25
p.A422V	SNU-407	large_intestine	COSMIC	FHGTWFLV	DEG_MDM2_SWIB_1	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P04070	Vitamin K-dependent protein C	DEG_MDM2_SWIB_1	410:417	FHGTWFLV	MDM2	0.7194	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons