DegronMD - P04278(SHBG)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P159L	TCGA-A5-A0GU	UCEC	TCGA	MRIALGGLL	DEG_APCC_DBOX_1	168:176	Mutation rewiring degron network	0.0833
p.P159L	SIDM00980	Gastric Carcinoma	GDSC	MRIALGGLL	DEG_APCC_DBOX_1	168:176	Mutation rewiring degron network	0.0833
p.P159L	ACH-000948	Gastric Cancer	CCLE	MRIALGGLL	DEG_APCC_DBOX_1	168:176	Mutation rewiring degron network	0.0833
p.L172I	TCGA-B5-A11Y	UCEC	TCGA	MRIALGGLL	DEG_APCC_DBOX_1	168:176	Mutation altering degron motif	0.7174
p.P178H	TCGA-GN-A265	SKCM	TCGA	MRIALGGLL	DEG_APCC_DBOX_1	168:176	Mutation rewiring degron network	0.2778
p.R164H	TCGA-HU-A4GQ	STAD	TCGA	MRIALGGLL	DEG_APCC_DBOX_1	168:176	Mutation rewiring degron network	0.2222
p.G166R	DO8264	COAD	ICGC	MRIALGGLL	DEG_APCC_DBOX_1	168:176	Mutation rewiring degron network	0.2778
p.P165L	DO37798	SKCM	ICGC	MRIALGGLL	DEG_APCC_DBOX_1	168:176	Mutation rewiring degron network	0.25
p.P170S	DO37450	SKCM	ICGC	MRIALGGLL	DEG_APCC_DBOX_1	168:176	Mutation altering degron motif	0.6752
p.P165S	DO47320	SKCM	ICGC	MRIALGGLL	DEG_APCC_DBOX_1	168:176	Mutation rewiring degron network	0.25
p.R180Q	DO42472	UCEC	ICGC	MRIALGGLL	DEG_APCC_DBOX_1	168:176	Mutation rewiring degron network	0.2222
p.G174R	ACH-001433	Sarcoma	CCLE	MRIALGGLL	DEG_APCC_DBOX_1	168:176	Mutation altering degron motif	0.6457
p.N181K	ACH-001857	Bile Duct Cancer	CCLE	MRIALGGLL	DEG_APCC_DBOX_1	168:176	Mutation rewiring degron network	0.1944
p.P178L	CW-2	large intestine	COSMIC	MRIALGGLL	DEG_APCC_DBOX_1	168:176	Mutation rewiring degron network	0.2778
p.P159S	EFO-27	ovary	COSMIC	MRIALGGLL	DEG_APCC_DBOX_1	168:176	Mutation rewiring degron network	0.0833

Kaplan plot for SHBG in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

SHBG

UniProt ID: P04278

Entrez ID: 6462

Protein name: Sex hormone-binding globulin (SHBG) (Sex steroid-binding protein) (SBP) (Testis-specific androgen-binding protein) (ABP) (Testosterone-estradiol-binding globulin) (TeBG) (Testosterone-estrogen-binding globulin)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for SHBG in