DegronMD

Uniprot ID: P04278

Source protein: Sex hormone-binding globulin

Source gene: SHBG

Class: DEG_APCC_DBOX_1

Location: 168:176

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.6788

ASA_SCORE: 30.3444

COIL: 0.4772

CONS_SCORE: 0.9299

DSS_SCORE: 0.09

HELIX: 0.022

FCONS_SCORE: 1.2987

RIG_SCORE: 0.8153

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.L172I	TCGA-B5-A11Y	UCEC	TCGA	MRIALGGLL	DEG_APCC_DBOX_1	0.7174
p.P170S	DO37450	SKCM	ICGC	MRIALGGLL	DEG_APCC_DBOX_1	0.6752
p.G174R	ACH-001433	Sarcoma	CCLE	MRIALGGLL	DEG_APCC_DBOX_1	0.6457
p.P178H	TCGA-GN-A265	SKCM	TCGA	MRIALGGLL	DEG_APCC_DBOX_1	0.2778
p.G166R	DO8264	COAD	ICGC	MRIALGGLL	DEG_APCC_DBOX_1	0.2778
p.P178L	CW-2	large_intestine	COSMIC	MRIALGGLL	DEG_APCC_DBOX_1	0.2778
p.P165L	DO37798	SKCM	ICGC	MRIALGGLL	DEG_APCC_DBOX_1	0.25
p.P165S	DO47320	SKCM	ICGC	MRIALGGLL	DEG_APCC_DBOX_1	0.25
p.R164H	TCGA-HU-A4GQ	STAD	TCGA	MRIALGGLL	DEG_APCC_DBOX_1	0.2222
p.R180Q	DO42472	UCEC	ICGC	MRIALGGLL	DEG_APCC_DBOX_1	0.2222
p.N181K	ACH-001857	Bile Duct Cancer	CCLE	MRIALGGLL	DEG_APCC_DBOX_1	0.1944
p.P159L	TCGA-A5-A0GU	UCEC	TCGA	MRIALGGLL	DEG_APCC_DBOX_1	0.0833
p.P159L	SIDM00980	Gastric Carcinoma	GDSC	MRIALGGLL	DEG_APCC_DBOX_1	0.0833
p.P159L	ACH-000948	Gastric Cancer	CCLE	MRIALGGLL	DEG_APCC_DBOX_1	0.0833
p.P159S	EFO-27	ovary	COSMIC	MRIALGGLL	DEG_APCC_DBOX_1	0.0833

Showing 1 to 15 of 15 entries

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P04278	Sex hormone-binding globulin	DEG_APCC_DBOX_1	168:176	MRIALGGLL	APC,CDC20,FZR1	0.6788	More...

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DegronMD: protein-targeted degradation, mutation and drug response to degrons