DegronMD - P04350(TUBB4A)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.L65M	TCGA-67-4679	LUAD	TCGA	PRAVLVDLE	DEG_APCC_DBOX_1	61:69	Mutation altering degron motif	0.711
p.G56V	TCGA-97-8174	LUAD	TCGA	PRAVLVDLE	DEG_APCC_DBOX_1	61:69	Mutation rewiring degron network	0.1944
p.G71S	TCGA-A5-A0G2	UCEC	TCGA	PRAVLVDLE	DEG_APCC_DBOX_1	61:69	Mutation rewiring degron network	0.2778
p.G71S	DO41235	UCEC	ICGC	PRAVLVDLE	DEG_APCC_DBOX_1	61:69	Mutation rewiring degron network	0.2778
p.E69K	TCGA-AB-2826	LAML	TCGA	PRAVLVDLE	DEG_APCC_DBOX_1	61:69	Mutation altering degron motif	0.591
p.S75Y	TCGA-AP-A0LM	UCEC	TCGA	PRAVLVDLE	DEG_APCC_DBOX_1	61:69	Mutation blocking phosphorylation signal	0.6111
p.S75Y	DO43306	UCEC	ICGC	PRAVLVDLE	DEG_APCC_DBOX_1	61:69	Mutation blocking phosphorylation signal	0.6111
p.R77C	TCGA-D3-A2JA	SKCM	TCGA	PRAVLVDLE	DEG_APCC_DBOX_1	61:69	Mutation rewiring degron network	0.1111
p.R77C	DO52135	PAEN	ICGC	PRAVLVDLE	DEG_APCC_DBOX_1	61:69	Mutation rewiring degron network	0.1111
p.R77C	DO47652	SKCM	ICGC	PRAVLVDLE	DEG_APCC_DBOX_1	61:69	Mutation rewiring degron network	0.1111
p.R62K	TCGA-EA-A3HU	CESC	TCGA	PRAVLVDLE	DEG_APCC_DBOX_1	61:69	Mutation altering degron motif	0.7237
p.R62K	DO6320	CESC	ICGC	PRAVLVDLE	DEG_APCC_DBOX_1	61:69	Mutation altering degron motif	0.7237
p.S78Y	TCGA-EO-A22U	UCEC	TCGA	PRAVLVDLE	DEG_APCC_DBOX_1	61:69	Mutation blocking phosphorylation signal	0.5278
p.S78Y	DO43755	UCEC	ICGC	PRAVLVDLE	DEG_APCC_DBOX_1	61:69	Mutation blocking phosphorylation signal	0.5278
p.A54T	TCGA-EO-A22X	UCEC	TCGA	PRAVLVDLE	DEG_APCC_DBOX_1	61:69	Mutation rewiring degron network	0.1389
p.A54T	DO43907	UCEC	ICGC	PRAVLVDLE	DEG_APCC_DBOX_1	61:69	Mutation rewiring degron network	0.1389
p.E53K	TCGA-GU-AATO	BLCA	TCGA	PRAVLVDLE	DEG_APCC_DBOX_1	61:69	Mutation rewiring degron network	0.1111
p.E53K	DO51893	BLCA	ICGC	PRAVLVDLE	DEG_APCC_DBOX_1	61:69	Mutation rewiring degron network	0.1111
p.R73Q	DO50045	BRCA	ICGC	PRAVLVDLE	DEG_APCC_DBOX_1	61:69	Mutation rewiring degron network	0.2222
p.R77H	DO222664	ESCA	ICGC	PRAVLVDLE	DEG_APCC_DBOX_1	61:69	Mutation rewiring degron network	0.1111
p.S76L	DO233888	GACA	ICGC	PRAVLVDLE	DEG_APCC_DBOX_1	61:69	Mutation rewiring degron network	0.1389
p.P56L	DO17858	KIRC	ICGC	PRAVLVDLE	DEG_APCC_DBOX_1	61:69	Mutation rewiring degron network	0.1944
p.P56L	DO48009	STAD	ICGC	PRAVLVDLE	DEG_APCC_DBOX_1	61:69	Mutation rewiring degron network	0.1944
p.V76F	DO228920	LICA	ICGC	PRAVLVDLE	DEG_APCC_DBOX_1	61:69	Mutation rewiring degron network	0.1389
p.F71L	DO229027	LICA	ICGC	PRAVLVDLE	DEG_APCC_DBOX_1	61:69	Mutation rewiring degron network	0.2778
p.N52K	DO229034	LICA	ICGC	PRAVLVDLE	DEG_APCC_DBOX_1	61:69	Mutation rewiring degron network	0.0833
p.P55L	DO222683	MELA	ICGC	PRAVLVDLE	DEG_APCC_DBOX_1	61:69	Mutation blocking phosphorylation signal	0.6111
p.P55L	DO37417	SKCM	ICGC	PRAVLVDLE	DEG_APCC_DBOX_1	61:69	Mutation blocking phosphorylation signal	0.6111
p.S70F	DO37715	SKCM	ICGC	PRAVLVDLE	DEG_APCC_DBOX_1	61:69	Mutation rewiring degron network	0.3056
p.P72Q	HCT-15	large intestine	COSMIC	PRAVLVDLE	DEG_APCC_DBOX_1	61:69	Mutation blocking phosphorylation signal	0.6944

Kaplan plot for TUBB4A in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

TUBB4A

UniProt ID: P04350

Entrez ID: 10382

Protein name: Tubulin beta-4A chain (Tubulin 5 beta) (Tubulin beta-4 chain)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for TUBB4A in