DegronMD

Uniprot ID: P04350

Source protein: Tubulin beta-4A chain

Source gene: TUBB4A

Class: DEG_APCC_DBOX_1

Location: 61:69

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.5297

ASA_SCORE: 22.4222

COIL: 0.3499

CONS_SCORE: 0.8958

DSS_SCORE: 0.2978

HELIX: 0.0179

FCONS_SCORE: 1.1012

RIG_SCORE: 0.8569

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.L65M	TCGA-67-4679	LUAD	TCGA	PRAVLVDLE	DEG_APCC_DBOX_1	0.711
p.G56V	TCGA-97-8174	LUAD	TCGA	PRAVLVDLE	DEG_APCC_DBOX_1	0.1944
p.G71S	TCGA-A5-A0G2	UCEC	TCGA	PRAVLVDLE	DEG_APCC_DBOX_1	0.2778
p.G71S	DO41235	UCEC	ICGC	PRAVLVDLE	DEG_APCC_DBOX_1	0.2778
p.E69K	TCGA-AB-2826	LAML	TCGA	PRAVLVDLE	DEG_APCC_DBOX_1	0.591
p.S75Y	TCGA-AP-A0LM	UCEC	TCGA	PRAVLVDLE	DEG_APCC_DBOX_1	0.6111
p.S75Y	DO43306	UCEC	ICGC	PRAVLVDLE	DEG_APCC_DBOX_1	0.6111
p.R77C	TCGA-D3-A2JA	SKCM	TCGA	PRAVLVDLE	DEG_APCC_DBOX_1	0.1111
p.R77C	DO52135	PAEN	ICGC	PRAVLVDLE	DEG_APCC_DBOX_1	0.1111
p.R77C	DO47652	SKCM	ICGC	PRAVLVDLE	DEG_APCC_DBOX_1	0.1111
p.R62K	TCGA-EA-A3HU	CESC	TCGA	PRAVLVDLE	DEG_APCC_DBOX_1	0.7237
p.R62K	DO6320	CESC	ICGC	PRAVLVDLE	DEG_APCC_DBOX_1	0.7237
p.S78Y	TCGA-EO-A22U	UCEC	TCGA	PRAVLVDLE	DEG_APCC_DBOX_1	0.5278
p.S78Y	DO43755	UCEC	ICGC	PRAVLVDLE	DEG_APCC_DBOX_1	0.5278
p.A54T	TCGA-EO-A22X	UCEC	TCGA	PRAVLVDLE	DEG_APCC_DBOX_1	0.1389
p.A54T	DO43907	UCEC	ICGC	PRAVLVDLE	DEG_APCC_DBOX_1	0.1389
p.E53K	TCGA-GU-AATO	BLCA	TCGA	PRAVLVDLE	DEG_APCC_DBOX_1	0.1111
p.E53K	DO51893	BLCA	ICGC	PRAVLVDLE	DEG_APCC_DBOX_1	0.1111
p.R73Q	DO50045	BRCA	ICGC	PRAVLVDLE	DEG_APCC_DBOX_1	0.2222
p.R77H	DO222664	ESCA	ICGC	PRAVLVDLE	DEG_APCC_DBOX_1	0.1111
p.S76L	DO233888	GACA	ICGC	PRAVLVDLE	DEG_APCC_DBOX_1	0.1389
p.P56L	DO17858	KIRC	ICGC	PRAVLVDLE	DEG_APCC_DBOX_1	0.1944
p.P56L	DO48009	STAD	ICGC	PRAVLVDLE	DEG_APCC_DBOX_1	0.1944
p.V76F	DO228920	LICA	ICGC	PRAVLVDLE	DEG_APCC_DBOX_1	0.1389
p.F71L	DO229027	LICA	ICGC	PRAVLVDLE	DEG_APCC_DBOX_1	0.2778
p.N52K	DO229034	LICA	ICGC	PRAVLVDLE	DEG_APCC_DBOX_1	0.0833
p.P55L	DO222683	MELA	ICGC	PRAVLVDLE	DEG_APCC_DBOX_1	0.6111
p.P55L	DO37417	SKCM	ICGC	PRAVLVDLE	DEG_APCC_DBOX_1	0.6111
p.S70F	DO37715	SKCM	ICGC	PRAVLVDLE	DEG_APCC_DBOX_1	0.3056
p.P72Q	HCT-15	large_intestine	COSMIC	PRAVLVDLE	DEG_APCC_DBOX_1	0.6944

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PRAVLVDLE

Degron related mutations and impact score

Drug responses associated with TUBB4A mutations

All proteins holding degron of PRAVLVDLE

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P04350	Tubulin beta-4A chain	DEG_APCC_DBOX_1	61:69	PRAVLVDLE	APC,CDC20,FZR1	0.5297	More...