DegronMD - P04554(PRM2)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R60Q	TCGA-CR-5248	HNSC	TCGA	SRRRLHRIH	DEG_APCC_DBOX_1	59:67	Mutation altering degron motif	0.7329
p.R60Q	DO14694	HNSC	ICGC	SRRRLHRIH	DEG_APCC_DBOX_1	59:67	Mutation altering degron motif	0.7329
p.R77H	TCGA-D5-6530	COAD	TCGA	SRRRLHRIH	DEG_APCC_DBOX_1	59:67	Mutation rewiring degron network	0.0556
p.R77H	TCGA-J9-A52C	PRAD	TCGA	SRRRLHRIH	DEG_APCC_DBOX_1	59:67	Mutation rewiring degron network	0.0556
p.R77H	DO8312	COAD	ICGC	SRRRLHRIH	DEG_APCC_DBOX_1	59:67	Mutation rewiring degron network	0.0556
p.R77H	DO51343	PRAD	ICGC	SRRRLHRIH	DEG_APCC_DBOX_1	59:67	Mutation rewiring degron network	0.0556
p.R72C	TCGA-EE-A3JD	SKCM	TCGA	SRRRLHRIH	DEG_APCC_DBOX_1	59:67	Mutation rewiring degron network	0.1944
p.R72C	DO50299	SKCM	ICGC	SRRRLHRIH	DEG_APCC_DBOX_1	59:67	Mutation rewiring degron network	0.1944
p.R55H	TCGA-EI-6917	READ	TCGA	SRRRLHRIH	DEG_APCC_DBOX_1	59:67	Mutation rewiring degron network	0.2222
p.R55H	DO36881	READ	ICGC	SRRRLHRIH	DEG_APCC_DBOX_1	59:67	Mutation rewiring degron network	0.2222
p.R55C	TCGA-FI-A2D0	UCEC	TCGA	SRRRLHRIH	DEG_APCC_DBOX_1	59:67	Mutation rewiring degron network	0.2222
p.R55C	DO43891	UCEC	ICGC	SRRRLHRIH	DEG_APCC_DBOX_1	59:67	Mutation rewiring degron network	0.2222
p.S73Y	TCGA-FS-A1ZG	SKCM	TCGA	SRRRLHRIH	DEG_APCC_DBOX_1	59:67	Mutation rewiring degron network	0.1667
p.S73Y	DO37523	SKCM	ICGC	SRRRLHRIH	DEG_APCC_DBOX_1	59:67	Mutation rewiring degron network	0.1667
p.H52N	TCGA-GU-AATQ	BLCA	TCGA	SRRRLHRIH	DEG_APCC_DBOX_1	59:67	Mutation rewiring degron network	0.1389
p.H52N	DO51896	BLCA	ICGC	SRRRLHRIH	DEG_APCC_DBOX_1	59:67	Mutation rewiring degron network	0.1389
p.H52D	DO48390	BLCA	ICGC	SRRRLHRIH	DEG_APCC_DBOX_1	59:67	Mutation rewiring degron network	0.1389
p.H67N	DO228952	LICA	ICGC	SRRRLHRIH	DEG_APCC_DBOX_1	59:67	Mutation altering degron motif	0.6312
p.S51Y	DO229029	LICA	ICGC	SRRRLHRIH	DEG_APCC_DBOX_1	59:67	Mutation rewiring degron network	0.1111
p.R55S	DO229009	LICA	ICGC	SRRRLHRIH	DEG_APCC_DBOX_1	59:67	Mutation rewiring degron network	0.2222
p.H71Y	SIDM01156	Small Cell Lung Carcinoma	GDSC	SRRRLHRIH	DEG_APCC_DBOX_1	59:67	Mutation rewiring degron network	0.2222
p.C74Y	SIDM00250	Esophageal Squamous Cell Carcinoma	GDSC	SRRRLHRIH	DEG_APCC_DBOX_1	59:67	Mutation rewiring degron network	0.1389
p.C74Y	ACH-000917	Esophageal Cancer	CCLE	SRRRLHRIH	DEG_APCC_DBOX_1	59:67	Mutation rewiring degron network	0.1389
p.C74Y	TE-4	oesophagus	COSMIC	SRRRLHRIH	DEG_APCC_DBOX_1	59:67	Mutation rewiring degron network	0.1389
p.R72H	SIDM00145	T-Lymphoblastic Leukemia	GDSC	SRRRLHRIH	DEG_APCC_DBOX_1	59:67	Mutation rewiring degron network	0.1944
p.R72H	ACH-001127	Leukemia	CCLE	SRRRLHRIH	DEG_APCC_DBOX_1	59:67	Mutation rewiring degron network	0.1944
p.R72H	MOLT-4	haematopoietic and lymphoid tissue	COSMIC	SRRRLHRIH	DEG_APCC_DBOX_1	59:67	Mutation rewiring degron network	0.1944

Kaplan plot for PRM2 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

PRM2

UniProt ID: P04554

Entrez ID: 5620

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for PRM2 in