DegronMD

Uniprot ID: P04554

Source protein: Protamine-2

Source gene: PRM2

Class: DEG_APCC_DBOX_1

Location: 59:67

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9445

ASA_SCORE: 124.4333

COIL: 0.4848

CONS_SCORE: 0.9196

DSS_SCORE: 0.5572

HELIX: 0.4648

FCONS_SCORE: 1.0108

RIG_SCORE: 0.6928

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R60Q	TCGA-CR-5248	HNSC	TCGA	SRRRLHRIH	DEG_APCC_DBOX_1	0.7329
p.R60Q	DO14694	HNSC	ICGC	SRRRLHRIH	DEG_APCC_DBOX_1	0.7329
p.R77H	TCGA-D5-6530	COAD	TCGA	SRRRLHRIH	DEG_APCC_DBOX_1	0.0556
p.R77H	TCGA-J9-A52C	PRAD	TCGA	SRRRLHRIH	DEG_APCC_DBOX_1	0.0556
p.R77H	DO8312	COAD	ICGC	SRRRLHRIH	DEG_APCC_DBOX_1	0.0556
p.R77H	DO51343	PRAD	ICGC	SRRRLHRIH	DEG_APCC_DBOX_1	0.0556
p.R72C	TCGA-EE-A3JD	SKCM	TCGA	SRRRLHRIH	DEG_APCC_DBOX_1	0.1944
p.R72C	DO50299	SKCM	ICGC	SRRRLHRIH	DEG_APCC_DBOX_1	0.1944
p.R55H	TCGA-EI-6917	READ	TCGA	SRRRLHRIH	DEG_APCC_DBOX_1	0.2222
p.R55H	DO36881	READ	ICGC	SRRRLHRIH	DEG_APCC_DBOX_1	0.2222
p.R55C	TCGA-FI-A2D0	UCEC	TCGA	SRRRLHRIH	DEG_APCC_DBOX_1	0.2222
p.R55C	DO43891	UCEC	ICGC	SRRRLHRIH	DEG_APCC_DBOX_1	0.2222
p.S73Y	TCGA-FS-A1ZG	SKCM	TCGA	SRRRLHRIH	DEG_APCC_DBOX_1	0.1667
p.S73Y	DO37523	SKCM	ICGC	SRRRLHRIH	DEG_APCC_DBOX_1	0.1667
p.H52N	TCGA-GU-AATQ	BLCA	TCGA	SRRRLHRIH	DEG_APCC_DBOX_1	0.1389
p.H52N	DO51896	BLCA	ICGC	SRRRLHRIH	DEG_APCC_DBOX_1	0.1389
p.H52D	DO48390	BLCA	ICGC	SRRRLHRIH	DEG_APCC_DBOX_1	0.1389
p.H67N	DO228952	LICA	ICGC	SRRRLHRIH	DEG_APCC_DBOX_1	0.6312
p.S51Y	DO229029	LICA	ICGC	SRRRLHRIH	DEG_APCC_DBOX_1	0.1111
p.R55S	DO229009	LICA	ICGC	SRRRLHRIH	DEG_APCC_DBOX_1	0.2222
p.H71Y	SIDM01156	Small Cell Lung Carcinoma	GDSC	SRRRLHRIH	DEG_APCC_DBOX_1	0.2222
p.C74Y	SIDM00250	Esophageal Squamous Cell Carcinoma	GDSC	SRRRLHRIH	DEG_APCC_DBOX_1	0.1389
p.C74Y	ACH-000917	Esophageal Cancer	CCLE	SRRRLHRIH	DEG_APCC_DBOX_1	0.1389
p.C74Y	TE-4	oesophagus	COSMIC	SRRRLHRIH	DEG_APCC_DBOX_1	0.1389
p.R72H	SIDM00145	T-Lymphoblastic Leukemia	GDSC	SRRRLHRIH	DEG_APCC_DBOX_1	0.1944
p.R72H	ACH-001127	Leukemia	CCLE	SRRRLHRIH	DEG_APCC_DBOX_1	0.1944
p.R72H	MOLT-4	haematopoietic_and_lymphoid_tissue	COSMIC	SRRRLHRIH	DEG_APCC_DBOX_1	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P04554	Protamine-2	DEG_APCC_DBOX_1	59:67	SRRRLHRIH	APC,CDC20,FZR1	0.9445	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: SRRRLHRIH

Degron related mutations and impact score

Drug responses associated with PRM2 mutations

All proteins holding degron of SRRRLHRIH