DegronMD - P04844(RPN2)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P522T	TCGA-57-1586	OV	TCGA	LFTPKQE	DEG_SCF_FBW7_2	519:525	Mutation altering degron motif	0.7031
p.E534Q	TCGA-DI-A1NO	UCEC	TCGA	LFTPKQE	DEG_SCF_FBW7_2	519:525	Mutation rewiring degron network	0.0833
p.S512L	TCGA-DK-AA74	BLCA	TCGA	LFTPKQE	DEG_SCF_FBW7_2	519:525	Mutation rewiring degron network	0.1389
p.S512L	SIDM00411	Pancreatic Carcinoma	GDSC	LFTPKQE	DEG_SCF_FBW7_2	519:525	Mutation rewiring degron network	0.1389
p.S512L	SIDM00472	Ovarian Carcinoma	GDSC	LFTPKQE	DEG_SCF_FBW7_2	519:525	Mutation rewiring degron network	0.1389
p.S512L	SIDM01363	Squamous Cell Lung Carcinoma	GDSC	LFTPKQE	DEG_SCF_FBW7_2	519:525	Mutation rewiring degron network	0.1389
p.S512L	PEO1	ovary	COSMIC	LFTPKQE	DEG_SCF_FBW7_2	519:525	Mutation rewiring degron network	0.1389
p.T521A	TCGA-DX-AB32	SARC	TCGA	LFTPKQE	DEG_SCF_FBW7_2	519:525	Mutation altering degron motif	0.825
p.E509K	TCGA-YC-A89H	BLCA	TCGA	LFTPKQE	DEG_SCF_FBW7_2	519:525	Mutation rewiring degron network	0.0556
p.E509K	SIDM01007	T-Lymphoblastic Leukemia	GDSC	LFTPKQE	DEG_SCF_FBW7_2	519:525	Mutation rewiring degron network	0.0556
p.E509K	KARPAS-45	haematopoietic and lymphoid tissue	COSMIC	LFTPKQE	DEG_SCF_FBW7_2	519:525	Mutation rewiring degron network	0.0556
p.A533S	DO228974	LICA	ICGC	LFTPKQE	DEG_SCF_FBW7_2	519:525	Mutation rewiring degron network	0.1111
p.V535F	DO229022	LICA	ICGC	LFTPKQE	DEG_SCF_FBW7_2	519:525	Mutation substituting flanking lysine	0.1667
p.R531C	SIDM01045	Endometrial Carcinoma	GDSC	LFTPKQE	DEG_SCF_FBW7_2	519:525	Mutation rewiring degron network	0.1667
p.R531C	EN	endometrium	COSMIC	LFTPKQE	DEG_SCF_FBW7_2	519:525	Mutation rewiring degron network	0.1667
p.L522F	ACH-002027	Endometrial/Uterine Cancer	CCLE	LFTPKQE	DEG_SCF_FBW7_2	519:525	Mutation altering degron motif	0.6981

Kaplan plot for RPN2 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

RPN2

UniProt ID: P04844

Entrez ID: 6185

Protein name: Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2 (Dolichyl-diphosphooligosaccharide--protein glycosyltransferase 63 kDa subunit) (RIBIIR) (Ribophorin II) (RPN-II) (Ribophorin-2)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for RPN2 in