DegronMD

Uniprot ID: P04844

Source protein: Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2

Source gene: RPN2

Class: DEG_SCF_FBW7_2

Location: 519:525

E3 ligase: FBXW7

DEGRON score: 0.6159

ASA_SCORE: 82.2

COIL: 0.7449

CONS_SCORE: 0.5741

DSS_SCORE: 0.3505

HELIX: 0.1711

FCONS_SCORE: 0.9745

RIG_SCORE: 0.7732

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P522T	TCGA-57-1586	OV	TCGA	LFTPKQE	DEG_SCF_FBW7_2	0.7031
p.E534Q	TCGA-DI-A1NO	UCEC	TCGA	LFTPKQE	DEG_SCF_FBW7_2	0.0833
p.S512L	TCGA-DK-AA74	BLCA	TCGA	LFTPKQE	DEG_SCF_FBW7_2	0.1389
p.S512L	SIDM00411	Pancreatic Carcinoma	GDSC	LFTPKQE	DEG_SCF_FBW7_2	0.1389
p.S512L	SIDM00472	Ovarian Carcinoma	GDSC	LFTPKQE	DEG_SCF_FBW7_2	0.1389
p.S512L	SIDM01363	Squamous Cell Lung Carcinoma	GDSC	LFTPKQE	DEG_SCF_FBW7_2	0.1389
p.S512L	PEO1	ovary	COSMIC	LFTPKQE	DEG_SCF_FBW7_2	0.1389
p.T521A	TCGA-DX-AB32	SARC	TCGA	LFTPKQE	DEG_SCF_FBW7_2	0.825
p.E509K	TCGA-YC-A89H	BLCA	TCGA	LFTPKQE	DEG_SCF_FBW7_2	0.0556
p.E509K	SIDM01007	T-Lymphoblastic Leukemia	GDSC	LFTPKQE	DEG_SCF_FBW7_2	0.0556
p.E509K	KARPAS-45	haematopoietic_and_lymphoid_tissue	COSMIC	LFTPKQE	DEG_SCF_FBW7_2	0.0556
p.A533S	DO228974	LICA	ICGC	LFTPKQE	DEG_SCF_FBW7_2	0.1111
p.V535F	DO229022	LICA	ICGC	LFTPKQE	DEG_SCF_FBW7_2	0.1667
p.R531C	SIDM01045	Endometrial Carcinoma	GDSC	LFTPKQE	DEG_SCF_FBW7_2	0.1667
p.R531C	EN	endometrium	COSMIC	LFTPKQE	DEG_SCF_FBW7_2	0.1667
p.L522F	ACH-002027	Endometrial/Uterine Cancer	CCLE	LFTPKQE	DEG_SCF_FBW7_2	0.6981

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P04844	Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2	DEG_SCF_FBW7_2	519:525	LFTPKQE	FBXW7	0.6159	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons