DegronMD - P05023(ATP1A1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.A73V	TCGA-77-8136	LUSC	TCGA	LTPPPT	DEG_SCF_FBW7_1	80:85	Mutation rewiring degron network	0.1389
p.E70Q	TCGA-AC-A23H	BRCA	TCGA	LTPPPT	DEG_SCF_FBW7_1	80:85	Mutation rewiring degron network	0.0556
p.L72P	TCGA-AX-A063	UCEC	TCGA	LTPPPT	DEG_SCF_FBW7_1	80:85	Mutation rewiring degron network	0.1111
p.L72M	TCGA-DU-6392	LGG	TCGA	LTPPPT	DEG_SCF_FBW7_1	80:85	Mutation rewiring degron network	0.1111
p.R94W	TCGA-FI-A2D5	UCEC	TCGA	LTPPPT	DEG_SCF_FBW7_1	80:85	Mutation rewiring degron network	0.0833
p.C93W	TCGA-VQ-AA6D	STAD	TCGA	LTPPPT	DEG_SCF_FBW7_1	80:85	Mutation rewiring degron network	0.1111
p.Q95H	DO8264	COAD	ICGC	LTPPPT	DEG_SCF_FBW7_1	80:85	Mutation rewiring degron network	0.0556
p.A77V	DO230315	COCA	ICGC	LTPPPT	DEG_SCF_FBW7_1	80:85	Mutation rewiring degron network	0.25
p.A77V	SNU-175	large intestine	COSMIC	LTPPPT	DEG_SCF_FBW7_1	80:85	Mutation rewiring degron network	0.25
p.A77V	SNU-C2B	large intestine	COSMIC	LTPPPT	DEG_SCF_FBW7_1	80:85	Mutation rewiring degron network	0.25
p.L73R	DO234230	ESAD	ICGC	LTPPPT	DEG_SCF_FBW7_1	80:85	Mutation rewiring degron network	0.1389
p.L79I	DO41758	UCEC	ICGC	LTPPPT	DEG_SCF_FBW7_1	80:85	Mutation rewiring degron network	0.3056
p.E93K	DO43891	UCEC	ICGC	LTPPPT	DEG_SCF_FBW7_1	80:85	Mutation rewiring degron network	0.1111
p.I78S	DO42673	UCEC	ICGC	LTPPPT	DEG_SCF_FBW7_1	80:85	Mutation rewiring degron network	0.2778
p.L80I	SIDM01609	Endometrial Carcinoma	GDSC	LTPPPT	DEG_SCF_FBW7_1	80:85	Mutation altering degron motif	0.6063
p.L80I	ACH-000972	Endometrial/Uterine Cancer	CCLE	LTPPPT	DEG_SCF_FBW7_1	80:85	Mutation altering degron motif	0.6063

Kaplan plot for ATP1A1 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

ATP1A1

UniProt ID: P05023

Entrez ID: 476

Protein name: Sodium/potassium-transporting ATPase subunit alpha-1 (Na(+)/K(+) ATPase alpha-1 subunit) (EC 7.2.2.13) (Sodium pump subunit alpha-1)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for ATP1A1 in