DegronMD

Uniprot ID: P05023

Source protein: Sodium/potassium-transporting ATPase subunit alpha-1

Source gene: ATP1A1

Class: DEG_SCF_FBW7_1

Location: 80:85

E3 ligase: FBXW7

DEGRON score: 0.9411

ASA_SCORE: 84.7667

COIL: 0.9418

CONS_SCORE: 0.5135

DSS_SCORE: 0.4303

HELIX: 0.0093

FCONS_SCORE: 1.1634

RIG_SCORE: 0.6964

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A73V	TCGA-77-8136	LUSC	TCGA	LTPPPT	DEG_SCF_FBW7_1	0.1389
p.E70Q	TCGA-AC-A23H	BRCA	TCGA	LTPPPT	DEG_SCF_FBW7_1	0.0556
p.L72P	TCGA-AX-A063	UCEC	TCGA	LTPPPT	DEG_SCF_FBW7_1	0.1111
p.L72M	TCGA-DU-6392	LGG	TCGA	LTPPPT	DEG_SCF_FBW7_1	0.1111
p.R94W	TCGA-FI-A2D5	UCEC	TCGA	LTPPPT	DEG_SCF_FBW7_1	0.0833
p.C93W	TCGA-VQ-AA6D	STAD	TCGA	LTPPPT	DEG_SCF_FBW7_1	0.1111
p.Q95H	DO8264	COAD	ICGC	LTPPPT	DEG_SCF_FBW7_1	0.0556
p.A77V	DO230315	COCA	ICGC	LTPPPT	DEG_SCF_FBW7_1	0.25
p.A77V	SNU-175	large_intestine	COSMIC	LTPPPT	DEG_SCF_FBW7_1	0.25
p.A77V	SNU-C2B	large_intestine	COSMIC	LTPPPT	DEG_SCF_FBW7_1	0.25
p.L73R	DO234230	ESAD	ICGC	LTPPPT	DEG_SCF_FBW7_1	0.1389
p.L79I	DO41758	UCEC	ICGC	LTPPPT	DEG_SCF_FBW7_1	0.3056
p.E93K	DO43891	UCEC	ICGC	LTPPPT	DEG_SCF_FBW7_1	0.1111
p.I78S	DO42673	UCEC	ICGC	LTPPPT	DEG_SCF_FBW7_1	0.2778
p.L80I	SIDM01609	Endometrial Carcinoma	GDSC	LTPPPT	DEG_SCF_FBW7_1	0.6063
p.L80I	ACH-000972	Endometrial/Uterine Cancer	CCLE	LTPPPT	DEG_SCF_FBW7_1	0.6063

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P05023	Sodium/potassium-transporting ATPase subunit alpha-1	DEG_SCF_FBW7_1	80:85	LTPPPT	FBXW7	0.9411	More...
P13637	Sodium/potassium-transporting ATPase subunit alpha-3	DEG_SCF_FBW7_1	70:75	LTPPPT	FBXW7	0.8645	More...
P50993	Sodium/potassium-transporting ATPase subunit alpha-2	DEG_SCF_FBW7_1	78:83	LTPPPT	FBXW7	0.8847	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons